Comparative Analysis of Ischemia‐Reperfusion Injury in Heart Transplantation: A Single‐Center Study Evaluating Conventional Ice‐Cold Storage versus the Paragonix SherpaPak Cardiac Transport System
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Wiley
2024
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| author | Dor Lotan Cathrine M. Moeller Afsana Rahman Gal Rubinstein Daniel Oren Yonatan Mehlman Andrea Fernandez Valledor Ersilia M. DeFilippis Jayant Raikhelkar Kevin Clerkin Justin Fried David Majure Yoshifumi Naka Yuji Kaku Koji Takeda Kyung Taek Oh Adil Yunis Paolo C Colombo Melana Yuzefpolskaya Farhana Latif Gabriel Sayer Nir Uriel Miroslav Sekulic |
| author_facet | Dor Lotan Cathrine M. Moeller Afsana Rahman Gal Rubinstein Daniel Oren Yonatan Mehlman Andrea Fernandez Valledor Ersilia M. DeFilippis Jayant Raikhelkar Kevin Clerkin Justin Fried David Majure Yoshifumi Naka Yuji Kaku Koji Takeda Kyung Taek Oh Adil Yunis Paolo C Colombo Melana Yuzefpolskaya Farhana Latif Gabriel Sayer Nir Uriel Miroslav Sekulic Dor Lotan Cathrine M. Moeller Afsana Rahman Gal Rubinstein Daniel Oren Yonatan Mehlman Andrea Fernandez Valledor Ersilia M. DeFilippis Jayant Raikhelkar Kevin Clerkin Justin Fried David Majure Yoshifumi Naka Yuji Kaku Koji Takeda Kyung Taek Oh Adil Yunis Paolo C Colombo Melana Yuzefpolskaya Farhana Latif Gabriel Sayer Nir Uriel Miroslav Sekulic |
| collection | Wiley Open Access |
| contents | Comparative Analysis of Ischemia‐Reperfusion Injury in Heart Transplantation: A Single‐Center Study Evaluating Conventional Ice‐Cold Storage versus the Paragonix SherpaPak Cardiac Transport System Dor Lotan Cathrine M. Moeller Afsana Rahman Gal Rubinstein Daniel Oren Yonatan Mehlman Andrea Fernandez Valledor Ersilia M. DeFilippis Jayant Raikhelkar Kevin Clerkin Justin Fried David Majure Yoshifumi Naka Yuji Kaku Koji Takeda Kyung Taek Oh Adil Yunis Paolo C Colombo Melana Yuzefpolskaya Farhana Latif Gabriel Sayer Nir Uriel Miroslav Sekulic Clinical Transplantation ABSTRACTBackgroundSince the 2018 allocation system change in heart transplantation (HT), ischemic times have increased, which may be associated with peri‐operative and post‐operative complications. This study aimed to compare ischemia reperfusion injury (IRI) in hearts preserved using ice‐cold storage (ICS) and the Paragonix SherpaPak TM Cardiac Transport System (CTS).MethodsFrom January 2021 to June 2022, consecutive endomyocardial biopsies from 90 HT recipients were analyzed by a cardiac pathologist in a single‐blinded manner: 33 ICS and 57 CTS. Endomyocardial biopsies were performed at three‐time intervals post‐HT, and the severity of IRI manifesting histologically as coagulative myocyte necrosis (CMN) was evaluated, along with graft rejection and graft function.ResultsThe incidence of IRI at weeks 1, 4, and 8 post‐HT were similar between the ICS and CTS groups. There was a 59.3% statistically significant reduction in CMN from week 1 to 4 with CTS, but not with ICS. By week 8, there were significant reductions in CMN in both groups. Only 1 out of 33 (3%) patients in the ICS group had an ischemic time >240 mins, compared to 10 out of 52 (19%) patients in the CTS group. During the follow‐up period of 8 weeks to 12 months, there were no significant differences in rejection rates, formation of de novo donor‐specific antibodies and overall survival between the groups.ConclusionThe CTS preservation system had similar rates of IRI and clinical outcomes compared to ICS despite longer overall ischemic times. There is significantly more recovery of IRI in the early post operative period with CTS. This study supports CTS as a viable option for preservation from remote locations, expanding the donor pool. 10.1111/ctr.15397 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/ctr.15397 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_ctr_15397 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Comparative Analysis of Ischemia‐Reperfusion Injury in Heart Transplantation: A Single‐Center Study Evaluating Conventional Ice‐Cold Storage versus the Paragonix SherpaPak Cardiac Transport System Dor Lotan Cathrine M. Moeller Afsana Rahman Gal Rubinstein Daniel Oren Yonatan Mehlman Andrea Fernandez Valledor Ersilia M. DeFilippis Jayant Raikhelkar Kevin Clerkin Justin Fried David Majure Yoshifumi Naka Yuji Kaku Koji Takeda Kyung Taek Oh Adil Yunis Paolo C Colombo Melana Yuzefpolskaya Farhana Latif Gabriel Sayer Nir Uriel Miroslav Sekulic Clinical Transplantation Comparative Analysis of Ischemia‐Reperfusion Injury in Heart Transplantation: A Single‐Center Study Evaluating Conventional Ice‐Cold Storage versus the Paragonix SherpaPak Cardiac Transport System Dor Lotan Cathrine M. Moeller Afsana Rahman Gal Rubinstein Daniel Oren Yonatan Mehlman Andrea Fernandez Valledor Ersilia M. DeFilippis Jayant Raikhelkar Kevin Clerkin Justin Fried David Majure Yoshifumi Naka Yuji Kaku Koji Takeda Kyung Taek Oh Adil Yunis Paolo C Colombo Melana Yuzefpolskaya Farhana Latif Gabriel Sayer Nir Uriel Miroslav Sekulic Clinical Transplantation ABSTRACTBackgroundSince the 2018 allocation system change in heart transplantation (HT), ischemic times have increased, which may be associated with peri‐operative and post‐operative complications. This study aimed to compare ischemia reperfusion injury (IRI) in hearts preserved using ice‐cold storage (ICS) and the Paragonix SherpaPak TM Cardiac Transport System (CTS).MethodsFrom January 2021 to June 2022, consecutive endomyocardial biopsies from 90 HT recipients were analyzed by a cardiac pathologist in a single‐blinded manner: 33 ICS and 57 CTS. Endomyocardial biopsies were performed at three‐time intervals post‐HT, and the severity of IRI manifesting histologically as coagulative myocyte necrosis (CMN) was evaluated, along with graft rejection and graft function.ResultsThe incidence of IRI at weeks 1, 4, and 8 post‐HT were similar between the ICS and CTS groups. There was a 59.3% statistically significant reduction in CMN from week 1 to 4 with CTS, but not with ICS. By week 8, there were significant reductions in CMN in both groups. Only 1 out of 33 (3%) patients in the ICS group had an ischemic time >240 mins, compared to 10 out of 52 (19%) patients in the CTS group. During the follow‐up period of 8 weeks to 12 months, there were no significant differences in rejection rates, formation of de novo donor‐specific antibodies and overall survival between the groups.ConclusionThe CTS preservation system had similar rates of IRI and clinical outcomes compared to ICS despite longer overall ischemic times. There is significantly more recovery of IRI in the early post operative period with CTS. This study supports CTS as a viable option for preservation from remote locations, expanding the donor pool. 10.1111/ctr.15397 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Comparative Analysis of Ischemia‐Reperfusion Injury in Heart Transplantation: A Single‐Center Study Evaluating Conventional Ice‐Cold Storage versus the Paragonix SherpaPak Cardiac Transport System |
| topic | Clinical Transplantation |
| url | https://onlinelibrary.wiley.com/doi/10.1111/ctr.15397 |