Cardio‐Renal‐Metabolic Outcomes Associated With the Use of GLP‐1 Receptor Agonists After Heart Transplantation
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Wiley
2024
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| author | Elena M. Donald Elissa Driggin Jason Choe Jaya Batra Fabian Vargas Jordan Lindekens Justin A. Fried Jayant K. Raikhelkar David J. Bae Kyung T. Oh Melana Yuzefpolskaya Paolo C. Colombo Farhana Latif Gabriel Sayer Nir Uriel Kevin J. Clerkin Ersilia M. DeFilippis |
| author_facet | Elena M. Donald Elissa Driggin Jason Choe Jaya Batra Fabian Vargas Jordan Lindekens Justin A. Fried Jayant K. Raikhelkar David J. Bae Kyung T. Oh Melana Yuzefpolskaya Paolo C. Colombo Farhana Latif Gabriel Sayer Nir Uriel Kevin J. Clerkin Ersilia M. DeFilippis Elena M. Donald Elissa Driggin Jason Choe Jaya Batra Fabian Vargas Jordan Lindekens Justin A. Fried Jayant K. Raikhelkar David J. Bae Kyung T. Oh Melana Yuzefpolskaya Paolo C. Colombo Farhana Latif Gabriel Sayer Nir Uriel Kevin J. Clerkin Ersilia M. DeFilippis |
| collection | Wiley Open Access |
| contents | Cardio‐Renal‐Metabolic Outcomes Associated With the Use of GLP‐1 Receptor Agonists After Heart Transplantation Elena M. Donald Elissa Driggin Jason Choe Jaya Batra Fabian Vargas Jordan Lindekens Justin A. Fried Jayant K. Raikhelkar David J. Bae Kyung T. Oh Melana Yuzefpolskaya Paolo C. Colombo Farhana Latif Gabriel Sayer Nir Uriel Kevin J. Clerkin Ersilia M. DeFilippis Clinical Transplantation ABSTRACTBackgroundThe use of glucagon‐like‐peptide 1 receptor agonists (GLP1‐RA) has dramatically increased over the past 5 years for diabetes mellitus type 2 (T2DM) and obesity. These comorbidities are prevalent in adult heart transplant (HT) recipients. However, there are limited data evaluating the efficacy of this drug class in this population. The aim of the current study was to describe cardiometabolic changes in HT recipients prescribed GLP1‐RA at a large‐volume transplant center.MethodsWe retrospectively reviewed all adult HT recipients who received GLP1‐RA after HT for a minimum of 1‐month. Cardiometabolic parameters including body mass index (BMI), lipid panel, hemoglobin A1C, estimated glomerular filtration rate (eGFR), and NT‐proBNP were compared prior to initiation of the drug and at most recent follow‐up. We also evaluated for significant dose adjustments to immunosuppression after drug initiation and adverse effects leading to drug discontinuation.ResultsSeventy‐four patients were included (28% female, 53% White, 20% Hispanic) and followed for a median of 383 days [IQR 209, 613] on a GLP1‐RA. The majority of patients (n = 56, 76%) were prescribed semaglutide. The most common indication for prescription was T2DM alone (n = 33, 45%), followed by combined T2DM and obesity (n = 26, 35%). At most recent follow‐up, mean BMI decreased from 33.3 to 31.5 kg/m2 (p < 0.0001), HbA1C from 7.3% to 6.7% (p = 0.005), LDL from 78.6 to 70.3 mg/dL (p = 0.018) and basal insulin daily dose from 32.6 to 24.8 units (p = 0.0002).ConclusionHT recipients prescribed GLP1‐RA therapy showed improved glycemic control, weight loss, and cholesterol levels during the study follow‐up period. GLP1‐RA were well tolerated and were rarely associated with changes in immunosuppression dosing. 10.1111/ctr.15401 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/ctr.15401 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_ctr_15401 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Cardio‐Renal‐Metabolic Outcomes Associated With the Use of GLP‐1 Receptor Agonists After Heart Transplantation Elena M. Donald Elissa Driggin Jason Choe Jaya Batra Fabian Vargas Jordan Lindekens Justin A. Fried Jayant K. Raikhelkar David J. Bae Kyung T. Oh Melana Yuzefpolskaya Paolo C. Colombo Farhana Latif Gabriel Sayer Nir Uriel Kevin J. Clerkin Ersilia M. DeFilippis Clinical Transplantation Cardio‐Renal‐Metabolic Outcomes Associated With the Use of GLP‐1 Receptor Agonists After Heart Transplantation Elena M. Donald Elissa Driggin Jason Choe Jaya Batra Fabian Vargas Jordan Lindekens Justin A. Fried Jayant K. Raikhelkar David J. Bae Kyung T. Oh Melana Yuzefpolskaya Paolo C. Colombo Farhana Latif Gabriel Sayer Nir Uriel Kevin J. Clerkin Ersilia M. DeFilippis Clinical Transplantation ABSTRACTBackgroundThe use of glucagon‐like‐peptide 1 receptor agonists (GLP1‐RA) has dramatically increased over the past 5 years for diabetes mellitus type 2 (T2DM) and obesity. These comorbidities are prevalent in adult heart transplant (HT) recipients. However, there are limited data evaluating the efficacy of this drug class in this population. The aim of the current study was to describe cardiometabolic changes in HT recipients prescribed GLP1‐RA at a large‐volume transplant center.MethodsWe retrospectively reviewed all adult HT recipients who received GLP1‐RA after HT for a minimum of 1‐month. Cardiometabolic parameters including body mass index (BMI), lipid panel, hemoglobin A1C, estimated glomerular filtration rate (eGFR), and NT‐proBNP were compared prior to initiation of the drug and at most recent follow‐up. We also evaluated for significant dose adjustments to immunosuppression after drug initiation and adverse effects leading to drug discontinuation.ResultsSeventy‐four patients were included (28% female, 53% White, 20% Hispanic) and followed for a median of 383 days [IQR 209, 613] on a GLP1‐RA. The majority of patients (n = 56, 76%) were prescribed semaglutide. The most common indication for prescription was T2DM alone (n = 33, 45%), followed by combined T2DM and obesity (n = 26, 35%). At most recent follow‐up, mean BMI decreased from 33.3 to 31.5 kg/m2 (p < 0.0001), HbA1C from 7.3% to 6.7% (p = 0.005), LDL from 78.6 to 70.3 mg/dL (p = 0.018) and basal insulin daily dose from 32.6 to 24.8 units (p = 0.0002).ConclusionHT recipients prescribed GLP1‐RA therapy showed improved glycemic control, weight loss, and cholesterol levels during the study follow‐up period. GLP1‐RA were well tolerated and were rarely associated with changes in immunosuppression dosing. 10.1111/ctr.15401 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Cardio‐Renal‐Metabolic Outcomes Associated With the Use of GLP‐1 Receptor Agonists After Heart Transplantation |
| topic | Clinical Transplantation |
| url | https://onlinelibrary.wiley.com/doi/10.1111/ctr.15401 |