Donor Atheromatous Disease is a Risk Factor for Hepatic Artery Thrombosis After Liver Transplantation
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| Natura: | Artículo Open Access |
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Wiley
2024
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| author | Javier M. Zamora‐Olaya Rocío Tejero‐Jurado Paloma E. Alañón‐Martínez María Prieto‐Torre Cristina Rodríguez‐Medina José L. Montero Marina Sánchez‐Frías Javier Briceño Rubén Ciria Pilar Barrera Antonio Poyato Manuel De la Mata Manuel L. Rodríguez‐Perálvarez |
| author_facet | Javier M. Zamora‐Olaya Rocío Tejero‐Jurado Paloma E. Alañón‐Martínez María Prieto‐Torre Cristina Rodríguez‐Medina José L. Montero Marina Sánchez‐Frías Javier Briceño Rubén Ciria Pilar Barrera Antonio Poyato Manuel De la Mata Manuel L. Rodríguez‐Perálvarez Javier M. Zamora‐Olaya Rocío Tejero‐Jurado Paloma E. Alañón‐Martínez María Prieto‐Torre Cristina Rodríguez‐Medina José L. Montero Marina Sánchez‐Frías Javier Briceño Rubén Ciria Pilar Barrera Antonio Poyato Manuel De la Mata Manuel L. Rodríguez‐Perálvarez |
| collection | Wiley Open Access |
| contents | Donor Atheromatous Disease is a Risk Factor for Hepatic Artery Thrombosis After Liver Transplantation Javier M. Zamora‐Olaya Rocío Tejero‐Jurado Paloma E. Alañón‐Martínez María Prieto‐Torre Cristina Rodríguez‐Medina José L. Montero Marina Sánchez‐Frías Javier Briceño Rubén Ciria Pilar Barrera Antonio Poyato Manuel De la Mata Manuel L. Rodríguez‐Perálvarez Clinical Transplantation ABSTRACTThe increasing age of liver donors and transplant candidates, together with the growing prevalence of metabolic comorbidities, could impact the risk of vascular complications after liver transplantation. We enrolled a consecutive cohort of adult patients undergoing liver transplantation from 2012 to 2021 who had a blinded pathological assessment of atherosclerosis in the donor and recipient hepatic arteries (HA). Patients receiving partial or reduced grafts, retransplantation, or combined organ transplantation were excluded. The relationship between HA atherosclerosis and HA thrombosis after liver transplantation was evaluated using logistic regression in the whole study cohort and in a propensity score‐matched subpopulation. Among 443 eligible patients, 272 had a full pathological evaluation of the donor and recipient HA and were included in the study. HA atheroma was present in 51.5% of donors and in 11.4% of recipients. HA thrombosis occurred in 16 patients (5.9%), being more likely in patients who received a donor with HA atherosclerosis than in those without (10.7% vs. 0.8%; p < 0.001). Donor HA atherosclerosis was an independent risk factor of HA thrombosis (OR = 17.79; p = 0.008), and this finding was consistent in the propensity score‐matched analysis according to age, sex, complex arterial anastomosis, and alcoholic liver disease (OR = 19.29; p = 0.007). Atheromatous disease in the recipient had no influence on the risk of HA thrombosis (OR = 1.70; p = 0.55). In conclusion, patients receiving donors with HA atherosclerosis are at increased risk for HA thrombosis after liver transplantation. The evaluation of the donor graft vasculature could guide antiplatelet therapy in the postoperative period. 10.1111/ctr.15405 http://creativecommons.org/licenses/by-nc/4.0/ |
| doi_str_mv | 10.1111/ctr.15405 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_ctr_15405 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by-nc/4.0/ |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Donor Atheromatous Disease is a Risk Factor for Hepatic Artery Thrombosis After Liver Transplantation Javier M. Zamora‐Olaya Rocío Tejero‐Jurado Paloma E. Alañón‐Martínez María Prieto‐Torre Cristina Rodríguez‐Medina José L. Montero Marina Sánchez‐Frías Javier Briceño Rubén Ciria Pilar Barrera Antonio Poyato Manuel De la Mata Manuel L. Rodríguez‐Perálvarez Clinical Transplantation Donor Atheromatous Disease is a Risk Factor for Hepatic Artery Thrombosis After Liver Transplantation Javier M. Zamora‐Olaya Rocío Tejero‐Jurado Paloma E. Alañón‐Martínez María Prieto‐Torre Cristina Rodríguez‐Medina José L. Montero Marina Sánchez‐Frías Javier Briceño Rubén Ciria Pilar Barrera Antonio Poyato Manuel De la Mata Manuel L. Rodríguez‐Perálvarez Clinical Transplantation ABSTRACTThe increasing age of liver donors and transplant candidates, together with the growing prevalence of metabolic comorbidities, could impact the risk of vascular complications after liver transplantation. We enrolled a consecutive cohort of adult patients undergoing liver transplantation from 2012 to 2021 who had a blinded pathological assessment of atherosclerosis in the donor and recipient hepatic arteries (HA). Patients receiving partial or reduced grafts, retransplantation, or combined organ transplantation were excluded. The relationship between HA atherosclerosis and HA thrombosis after liver transplantation was evaluated using logistic regression in the whole study cohort and in a propensity score‐matched subpopulation. Among 443 eligible patients, 272 had a full pathological evaluation of the donor and recipient HA and were included in the study. HA atheroma was present in 51.5% of donors and in 11.4% of recipients. HA thrombosis occurred in 16 patients (5.9%), being more likely in patients who received a donor with HA atherosclerosis than in those without (10.7% vs. 0.8%; p < 0.001). Donor HA atherosclerosis was an independent risk factor of HA thrombosis (OR = 17.79; p = 0.008), and this finding was consistent in the propensity score‐matched analysis according to age, sex, complex arterial anastomosis, and alcoholic liver disease (OR = 19.29; p = 0.007). Atheromatous disease in the recipient had no influence on the risk of HA thrombosis (OR = 1.70; p = 0.55). In conclusion, patients receiving donors with HA atherosclerosis are at increased risk for HA thrombosis after liver transplantation. The evaluation of the donor graft vasculature could guide antiplatelet therapy in the postoperative period. 10.1111/ctr.15405 http://creativecommons.org/licenses/by-nc/4.0/ |
| title | Donor Atheromatous Disease is a Risk Factor for Hepatic Artery Thrombosis After Liver Transplantation |
| topic | Clinical Transplantation |
| url | https://onlinelibrary.wiley.com/doi/10.1111/ctr.15405 |