Enregistré dans:
| Auteurs principaux: | , , , , , , , , , , |
|---|---|
| Format: | Artículo Open Access |
| Publié: |
Wiley
2024
|
| Sujets: | |
| Accès en ligne: | https://onlinelibrary.wiley.com/doi/10.1111/ctr.15420 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
| _version_ | 1867002305841201153 |
|---|---|
| author | Xinyi Huang David Salerno Danielle Kovac Jenna Scheffert Jessica Hedvat Bayleigh Carver Jason Choe Tara Shertel Melana Yuzefpolskaya Paolo C. Colombo Douglas L. Jennings |
| author_facet | Xinyi Huang David Salerno Danielle Kovac Jenna Scheffert Jessica Hedvat Bayleigh Carver Jason Choe Tara Shertel Melana Yuzefpolskaya Paolo C. Colombo Douglas L. Jennings Xinyi Huang David Salerno Danielle Kovac Jenna Scheffert Jessica Hedvat Bayleigh Carver Jason Choe Tara Shertel Melana Yuzefpolskaya Paolo C. Colombo Douglas L. Jennings |
| collection | Wiley Open Access |
| contents | Contemporary Immunosuppression Management and 1‐Year Outcomes in Dual Organ Heart Transplantation Xinyi Huang David Salerno Danielle Kovac Jenna Scheffert Jessica Hedvat Bayleigh Carver Jason Choe Tara Shertel Melana Yuzefpolskaya Paolo C. Colombo Douglas L. Jennings Clinical Transplantation ABSTRACTBackgroundThere have been limited reports on immunosuppression strategies and outcomes in dual organ heart transplant populations, primarily from before the 2018 United Network for Organ Sharing (UNOS) heart allocation policy change. Recent data suggested that outcomes with heart–lung and heart–liver transplants remained comparable in the new allocation era, yet heart–kidney recipients have worse 1‐year survival.MethodsThis single‐center retrospective study evaluated adult heart–kidney, heart–liver, and heart–lung transplant recipients from September 2019 to May 2023. Immunosuppression regimen, infectious complications, and graft outcomes were collected for 12 months.ResultsA total of 36 patients (kidney n = 20, liver n = 9, and lung n = 7) were included in this study. Basiliximab was the most commonly employed induction strategy across the organ groups (12/20 in kidney, 4/9 in liver, and 7/7 in lung). All patients were on triple immunosuppression at 12 months posttransplant with prednisone wean achieved in one heart–liver recipient. Infection complications were frequently reported (95% kidney, 75% liver, 100% lung group). One patient went back to dialysis due to focal segmental glomerulosclerosis. One chronic lung allograft dysfunction was reported, but no other severe biopsy‐proven rejection or retransplant was reported. The 1‐year survival was 85% (17/20) in heart–kidney, 78% (7/9) in heart–liver, and 86% (6/7) in heart–lung recipients.ConclusionThis study summarized real‐world immunosuppression strategies and outcomes in dual organ heart transplant recipients. 10.1111/ctr.15420 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/ctr.15420 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_ctr_15420 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Contemporary Immunosuppression Management and 1‐Year Outcomes in Dual Organ Heart Transplantation Xinyi Huang David Salerno Danielle Kovac Jenna Scheffert Jessica Hedvat Bayleigh Carver Jason Choe Tara Shertel Melana Yuzefpolskaya Paolo C. Colombo Douglas L. Jennings Clinical Transplantation Contemporary Immunosuppression Management and 1‐Year Outcomes in Dual Organ Heart Transplantation Xinyi Huang David Salerno Danielle Kovac Jenna Scheffert Jessica Hedvat Bayleigh Carver Jason Choe Tara Shertel Melana Yuzefpolskaya Paolo C. Colombo Douglas L. Jennings Clinical Transplantation ABSTRACTBackgroundThere have been limited reports on immunosuppression strategies and outcomes in dual organ heart transplant populations, primarily from before the 2018 United Network for Organ Sharing (UNOS) heart allocation policy change. Recent data suggested that outcomes with heart–lung and heart–liver transplants remained comparable in the new allocation era, yet heart–kidney recipients have worse 1‐year survival.MethodsThis single‐center retrospective study evaluated adult heart–kidney, heart–liver, and heart–lung transplant recipients from September 2019 to May 2023. Immunosuppression regimen, infectious complications, and graft outcomes were collected for 12 months.ResultsA total of 36 patients (kidney n = 20, liver n = 9, and lung n = 7) were included in this study. Basiliximab was the most commonly employed induction strategy across the organ groups (12/20 in kidney, 4/9 in liver, and 7/7 in lung). All patients were on triple immunosuppression at 12 months posttransplant with prednisone wean achieved in one heart–liver recipient. Infection complications were frequently reported (95% kidney, 75% liver, 100% lung group). One patient went back to dialysis due to focal segmental glomerulosclerosis. One chronic lung allograft dysfunction was reported, but no other severe biopsy‐proven rejection or retransplant was reported. The 1‐year survival was 85% (17/20) in heart–kidney, 78% (7/9) in heart–liver, and 86% (6/7) in heart–lung recipients.ConclusionThis study summarized real‐world immunosuppression strategies and outcomes in dual organ heart transplant recipients. 10.1111/ctr.15420 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Contemporary Immunosuppression Management and 1‐Year Outcomes in Dual Organ Heart Transplantation |
| topic | Clinical Transplantation |
| url | https://onlinelibrary.wiley.com/doi/10.1111/ctr.15420 |