Does Severity of Donor Acute Kidney Injury Influence Outcomes Following Kidney Transplantation?
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Wiley
2024
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| author | Alexandra R. Monetti Christopher J. Webb Colleen L. Jay Emily McCracken Berjesh Sharda Matthew Garner Alan C. Farney Giuseppe Orlando Amber Reeves‐Daniel Alejandra Mena‐Gutierrez Natalia Sakhovskaya Robert J. Stratta |
| author_facet | Alexandra R. Monetti Christopher J. Webb Colleen L. Jay Emily McCracken Berjesh Sharda Matthew Garner Alan C. Farney Giuseppe Orlando Amber Reeves‐Daniel Alejandra Mena‐Gutierrez Natalia Sakhovskaya Robert J. Stratta Alexandra R. Monetti Christopher J. Webb Colleen L. Jay Emily McCracken Berjesh Sharda Matthew Garner Alan C. Farney Giuseppe Orlando Amber Reeves‐Daniel Alejandra Mena‐Gutierrez Natalia Sakhovskaya Robert J. Stratta |
| collection | Wiley Open Access |
| contents | Does Severity of Donor Acute Kidney Injury Influence Outcomes Following Kidney Transplantation? Alexandra R. Monetti Christopher J. Webb Colleen L. Jay Emily McCracken Berjesh Sharda Matthew Garner Alan C. Farney Giuseppe Orlando Amber Reeves‐Daniel Alejandra Mena‐Gutierrez Natalia Sakhovskaya Robert J. Stratta Clinical Transplantation ABSTRACTIntroductionThe study purpose was to review retrospectively our single‐center experience transplanting kidneys from deceased donors (DD) with acute kidney injury (AKI) according to terminal serum creatinine (tSCr) level.MethodsAKI kidneys were defined by a doubling of the DD's admission SCr and a tSCr ≥ 2.0 mg/dL.ResultsFrom 1/07 to 11/21, we transplanted 236 AKI DD kidneys, including 100 with a tSCr ≥ 3.0 mg/dL (high SCr AKI group, mean tSCr 4.2 mg/dL), and the remaining 136 from DDs with a tSCr of 2.0–2.99 mg/dL (lower SCr AKI group, mean tSCr 2.4 mg/dL). These two AKI groups were compared to 996 concurrent control patients receiving DD kidneys with a tSCr < 1.0 mg/dL. Mean follow‐up was 69 months. Delayed graft function (DGF) rates were 51% versus 46% versus 29% (p < 0.0001), and 5‐year patient and death‐censored kidney graft survival rates were 96.8% versus 83.5% versus 82.2% (p = 0.002) and 86.7% versus 77.8% versus 78.8% (p = 0.18) in the high tSCr AKI versus lower tSCr AKI versus control groups, respectively.ConclusionsDespite a higher incidence of DGF, patients receiving kidneys from DDs with tSCr levels ≥3.0 mg/dL have acceptable medium‐term outcomes compared to either AKI DDs with a lower tSCr or DDs with a tSCr < 1.0 mg/dL. 10.1111/ctr.15425 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/ctr.15425 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_ctr_15425 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Does Severity of Donor Acute Kidney Injury Influence Outcomes Following Kidney Transplantation? Alexandra R. Monetti Christopher J. Webb Colleen L. Jay Emily McCracken Berjesh Sharda Matthew Garner Alan C. Farney Giuseppe Orlando Amber Reeves‐Daniel Alejandra Mena‐Gutierrez Natalia Sakhovskaya Robert J. Stratta Clinical Transplantation Does Severity of Donor Acute Kidney Injury Influence Outcomes Following Kidney Transplantation? Alexandra R. Monetti Christopher J. Webb Colleen L. Jay Emily McCracken Berjesh Sharda Matthew Garner Alan C. Farney Giuseppe Orlando Amber Reeves‐Daniel Alejandra Mena‐Gutierrez Natalia Sakhovskaya Robert J. Stratta Clinical Transplantation ABSTRACTIntroductionThe study purpose was to review retrospectively our single‐center experience transplanting kidneys from deceased donors (DD) with acute kidney injury (AKI) according to terminal serum creatinine (tSCr) level.MethodsAKI kidneys were defined by a doubling of the DD's admission SCr and a tSCr ≥ 2.0 mg/dL.ResultsFrom 1/07 to 11/21, we transplanted 236 AKI DD kidneys, including 100 with a tSCr ≥ 3.0 mg/dL (high SCr AKI group, mean tSCr 4.2 mg/dL), and the remaining 136 from DDs with a tSCr of 2.0–2.99 mg/dL (lower SCr AKI group, mean tSCr 2.4 mg/dL). These two AKI groups were compared to 996 concurrent control patients receiving DD kidneys with a tSCr < 1.0 mg/dL. Mean follow‐up was 69 months. Delayed graft function (DGF) rates were 51% versus 46% versus 29% (p < 0.0001), and 5‐year patient and death‐censored kidney graft survival rates were 96.8% versus 83.5% versus 82.2% (p = 0.002) and 86.7% versus 77.8% versus 78.8% (p = 0.18) in the high tSCr AKI versus lower tSCr AKI versus control groups, respectively.ConclusionsDespite a higher incidence of DGF, patients receiving kidneys from DDs with tSCr levels ≥3.0 mg/dL have acceptable medium‐term outcomes compared to either AKI DDs with a lower tSCr or DDs with a tSCr < 1.0 mg/dL. 10.1111/ctr.15425 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Does Severity of Donor Acute Kidney Injury Influence Outcomes Following Kidney Transplantation? |
| topic | Clinical Transplantation |
| url | https://onlinelibrary.wiley.com/doi/10.1111/ctr.15425 |