Tuscany Normothermic Regional Perfusion Mobile Teams for Controlled Donation After Circulatory Death

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Autori principali: Chiara Lazzeri, Bonizzoli Manuela, Sara Bagatti, Stefano Antonelli, Paolo Lo Pane, Davide Ghinolfi, Adriano Peris
Natura: Artículo Open Access
Pubblicazione: Wiley 2024
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author Chiara Lazzeri
Bonizzoli Manuela
Sara Bagatti
Stefano Antonelli
Paolo Lo Pane
Davide Ghinolfi
Adriano Peris
author_facet Chiara Lazzeri
Bonizzoli Manuela
Sara Bagatti
Stefano Antonelli
Paolo Lo Pane
Davide Ghinolfi
Adriano Peris
Chiara Lazzeri
Bonizzoli Manuela
Sara Bagatti
Stefano Antonelli
Paolo Lo Pane
Davide Ghinolfi
Adriano Peris
collection Wiley Open Access
contents Tuscany Normothermic Regional Perfusion Mobile Teams for Controlled Donation After Circulatory Death Chiara Lazzeri Bonizzoli Manuela Sara Bagatti Stefano Antonelli Paolo Lo Pane Davide Ghinolfi Adriano Peris Clinical Transplantation ABSTRACTIntroductionTo facilitate the implementation of controlled donation after circulatory death (cDCD) programs even in hospitals not equipped with a local extracorporeal membrane oxygenation (ECMO) team, some countries have launched a local cDCD network with an ECMO mobile team for normothermic regional perfusion (NRP). In the Tuscany region, in 2021, the Regional Transplant Authority launched a cDCD program to make the cDCD pathway feasible even in peripheral hospitals with NRP mobile teams, which were “converted” existing ECMO mobile teams, composed of highly skilled and experienced personnel.MethodsWe describe the Tuscany cDCD program, (2021–2023), for cDCD from peripheral hospitals with NRP mobile teams.ResultsTwenty‐six cDCDs (26/40, 65%) came from peripheral hospitals. Following the launch of the cDCD program, cDCDs from peripheral hospitals increased, from 33% (2021) to 75% (2022 and 2023) of the overall cDCDs. The mean age was 63 years, with older donors (>75 years) in half the cases. The median warm ischemia time was 45 min (20 min are required by the Italian law for death certification), ranging from 35 to 59 min. Among the 20 livers retrieved and 18 kidneys retrieved, 16 livers, and 11 kidneys (single kidney transplantation) were transplanted, after ex vivo reperfusion, respectively.ConclusionsThe use of NRP mobile teams proved to be feasible and safe in the management of cDCD in peripheral hospitals. No complications were reported with NRP despite the advanced age of most cDCDs. 10.1111/ctr.15429 http://onlinelibrary.wiley.com/termsAndConditions#vor
doi_str_mv 10.1111/ctr.15429
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publishDate 2024
publisher Wiley
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spellingShingle Tuscany Normothermic Regional Perfusion Mobile Teams for Controlled Donation After Circulatory Death
Chiara Lazzeri
Bonizzoli Manuela
Sara Bagatti
Stefano Antonelli
Paolo Lo Pane
Davide Ghinolfi
Adriano Peris
Clinical Transplantation
Tuscany Normothermic Regional Perfusion Mobile Teams for Controlled Donation After Circulatory Death Chiara Lazzeri Bonizzoli Manuela Sara Bagatti Stefano Antonelli Paolo Lo Pane Davide Ghinolfi Adriano Peris Clinical Transplantation ABSTRACTIntroductionTo facilitate the implementation of controlled donation after circulatory death (cDCD) programs even in hospitals not equipped with a local extracorporeal membrane oxygenation (ECMO) team, some countries have launched a local cDCD network with an ECMO mobile team for normothermic regional perfusion (NRP). In the Tuscany region, in 2021, the Regional Transplant Authority launched a cDCD program to make the cDCD pathway feasible even in peripheral hospitals with NRP mobile teams, which were “converted” existing ECMO mobile teams, composed of highly skilled and experienced personnel.MethodsWe describe the Tuscany cDCD program, (2021–2023), for cDCD from peripheral hospitals with NRP mobile teams.ResultsTwenty‐six cDCDs (26/40, 65%) came from peripheral hospitals. Following the launch of the cDCD program, cDCDs from peripheral hospitals increased, from 33% (2021) to 75% (2022 and 2023) of the overall cDCDs. The mean age was 63 years, with older donors (>75 years) in half the cases. The median warm ischemia time was 45 min (20 min are required by the Italian law for death certification), ranging from 35 to 59 min. Among the 20 livers retrieved and 18 kidneys retrieved, 16 livers, and 11 kidneys (single kidney transplantation) were transplanted, after ex vivo reperfusion, respectively.ConclusionsThe use of NRP mobile teams proved to be feasible and safe in the management of cDCD in peripheral hospitals. No complications were reported with NRP despite the advanced age of most cDCDs. 10.1111/ctr.15429 http://onlinelibrary.wiley.com/termsAndConditions#vor
title Tuscany Normothermic Regional Perfusion Mobile Teams for Controlled Donation After Circulatory Death
topic Clinical Transplantation
url https://onlinelibrary.wiley.com/doi/10.1111/ctr.15429