Risk Factors for Sinusoidal Obstruction Syndrome After Hematopoietic Stem Cell Transplantation in Children and Young Adults: A Systematic Review and Meta‐Analysis
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2024
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| author | Kai Cui Jie Chen Senlin Zhang ChenChen He Shan Sun Jie Li |
| author_facet | Kai Cui Jie Chen Senlin Zhang ChenChen He Shan Sun Jie Li Kai Cui Jie Chen Senlin Zhang ChenChen He Shan Sun Jie Li |
| collection | Wiley Open Access |
| contents | Risk Factors for Sinusoidal Obstruction Syndrome After Hematopoietic Stem Cell Transplantation in Children and Young Adults: A Systematic Review and Meta‐Analysis Kai Cui Jie Chen Senlin Zhang ChenChen He Shan Sun Jie Li Clinical Transplantation ABSTRACTObjective and BackgroundSinusoidal obstruction syndrome (SOS) is a life‐threatening complication in hematopoietic stem cell transplantation (HSCT) patients. However, the related risk factors in pediatric and young adult HSCT recipients remain unclear. Thus, we conducted this meta‐analysis to identify potential risk factors for SOS in children and young adults undergoing HSCT.MethodWe acquired related articles through searching PubMed, EMBASE, and the Cochrane Library up to May 31, 2024. We calculated odds ratios (ORs) and corresponding 95% confidence intervals (CIs) to identify potential risk factors.ResultsA total of 12 studies with 7644 HSCT recipients were included. Bone marrow transplantation (OR = 1.35, 95% CI: 1.03–1.77, I2 = 0%), busulfan (BU) (OR = 3.63, 95% CI: 1.78–7.38, I2 = 70%), and fludarabine (FLU) (OR = 1.55, 95% CI: 1.09–2.21, I2 = 16%) were risk factors for SOS after HSCT in children and young adults.ConclusionBone marrow transplantation and the use of BU or FLU might be risk factors for SOS after HSCT in children and young adults. 10.1111/ctr.15449 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/ctr.15449 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_ctr_15449 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Risk Factors for Sinusoidal Obstruction Syndrome After Hematopoietic Stem Cell Transplantation in Children and Young Adults: A Systematic Review and Meta‐Analysis Kai Cui Jie Chen Senlin Zhang ChenChen He Shan Sun Jie Li Clinical Transplantation Risk Factors for Sinusoidal Obstruction Syndrome After Hematopoietic Stem Cell Transplantation in Children and Young Adults: A Systematic Review and Meta‐Analysis Kai Cui Jie Chen Senlin Zhang ChenChen He Shan Sun Jie Li Clinical Transplantation ABSTRACTObjective and BackgroundSinusoidal obstruction syndrome (SOS) is a life‐threatening complication in hematopoietic stem cell transplantation (HSCT) patients. However, the related risk factors in pediatric and young adult HSCT recipients remain unclear. Thus, we conducted this meta‐analysis to identify potential risk factors for SOS in children and young adults undergoing HSCT.MethodWe acquired related articles through searching PubMed, EMBASE, and the Cochrane Library up to May 31, 2024. We calculated odds ratios (ORs) and corresponding 95% confidence intervals (CIs) to identify potential risk factors.ResultsA total of 12 studies with 7644 HSCT recipients were included. Bone marrow transplantation (OR = 1.35, 95% CI: 1.03–1.77, I2 = 0%), busulfan (BU) (OR = 3.63, 95% CI: 1.78–7.38, I2 = 70%), and fludarabine (FLU) (OR = 1.55, 95% CI: 1.09–2.21, I2 = 16%) were risk factors for SOS after HSCT in children and young adults.ConclusionBone marrow transplantation and the use of BU or FLU might be risk factors for SOS after HSCT in children and young adults. 10.1111/ctr.15449 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Risk Factors for Sinusoidal Obstruction Syndrome After Hematopoietic Stem Cell Transplantation in Children and Young Adults: A Systematic Review and Meta‐Analysis |
| topic | Clinical Transplantation |
| url | https://onlinelibrary.wiley.com/doi/10.1111/ctr.15449 |