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| Natura: | Artículo Open Access |
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Wiley
2025
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| Accesso online: | https://onlinelibrary.wiley.com/doi/10.1111/ctr.70086 |
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| author | Annabel K. Gravely Marco P. A. W. Claasen Tommy Ivanics Erin Winter Peregrina Peralta Markus Selzner Gonzalo Sapisochin |
| author_facet | Annabel K. Gravely Marco P. A. W. Claasen Tommy Ivanics Erin Winter Peregrina Peralta Markus Selzner Gonzalo Sapisochin Annabel K. Gravely Marco P. A. W. Claasen Tommy Ivanics Erin Winter Peregrina Peralta Markus Selzner Gonzalo Sapisochin |
| collection | Wiley Open Access |
| contents | Factor V Serves as an Early Biomarker for Graft Loss After Liver Transplant: A Prospective Evaluation Annabel K. Gravely Marco P. A. W. Claasen Tommy Ivanics Erin Winter Peregrina Peralta Markus Selzner Gonzalo Sapisochin Clinical Transplantation ABSTRACTBackgroundLow post‐operative day (POD) 1 Factor V has been retrospectively associated with graft loss after liver transplantation when stratified by a cutoff of 0.36 U/mL. We aimed to validate this prospectively.MethodsPatients transplanted at Toronto General Hospital were recruited (May 2018–March 2021). Factor V measurements were obtained on POD1‐3, 5, and 7. Graft and patient survival at 3, 6, and 12 months were primary and secondary outcomes, respectively. We identified an optimal cutoff through receiver operating characteristic (ROC) analysis and the Youden index. Kaplan–Meier method and Log‐rank tests were used to assess/compare survival.ResultsOne hundred and twenty‐nine patients were included. One hundred and eight had Factor V >0.36 and 21 had ≤0.36 U/mL. This cutoff was predictive of 6‐ and 12‐month graft survival and 12‐month patient survival. With an optimal cutoff of 0.46 U/mL on POD1, 87 patients had Factor V >0.46 and 42 had ≤0.46 U/mL. Three‐, 6‐, and 12‐month graft survival rates were 100%, 98.8%, and 98.8%, for patients with Factor V >0.46 U/mL, and 92.9%, 87.7%, and 87.7% for Factor V ≤0.46 U/mL. Similarly, 3‐, 6‐, and 12‐month patient survival rates were 98.8%, 96.4%, and 95.0% for patients with Factor V >0.46 U/mL, and 92.9%, 88.0%, and 82.9% for Factor V ≤0.46 U/mL. Stratification below the novel cutoff was associated with decreased graft survival at months 3 (p = 0.012), 6 (p = 0.006), and 12 (p = 0.006), and decreased patient survival at 12 months (p = 0.022).ConclusionsFactor V serves as an early biomarker for graft loss, with an optimal predictive cutoff of 0.46 U/mL in this prospective population. Validation of this new cutoff is necessary. 10.1111/ctr.70086 http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| doi_str_mv | 10.1111/ctr.70086 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_ctr_70086 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Factor V Serves as an Early Biomarker for Graft Loss After Liver Transplant: A Prospective Evaluation Annabel K. Gravely Marco P. A. W. Claasen Tommy Ivanics Erin Winter Peregrina Peralta Markus Selzner Gonzalo Sapisochin Clinical Transplantation Factor V Serves as an Early Biomarker for Graft Loss After Liver Transplant: A Prospective Evaluation Annabel K. Gravely Marco P. A. W. Claasen Tommy Ivanics Erin Winter Peregrina Peralta Markus Selzner Gonzalo Sapisochin Clinical Transplantation ABSTRACTBackgroundLow post‐operative day (POD) 1 Factor V has been retrospectively associated with graft loss after liver transplantation when stratified by a cutoff of 0.36 U/mL. We aimed to validate this prospectively.MethodsPatients transplanted at Toronto General Hospital were recruited (May 2018–March 2021). Factor V measurements were obtained on POD1‐3, 5, and 7. Graft and patient survival at 3, 6, and 12 months were primary and secondary outcomes, respectively. We identified an optimal cutoff through receiver operating characteristic (ROC) analysis and the Youden index. Kaplan–Meier method and Log‐rank tests were used to assess/compare survival.ResultsOne hundred and twenty‐nine patients were included. One hundred and eight had Factor V >0.36 and 21 had ≤0.36 U/mL. This cutoff was predictive of 6‐ and 12‐month graft survival and 12‐month patient survival. With an optimal cutoff of 0.46 U/mL on POD1, 87 patients had Factor V >0.46 and 42 had ≤0.46 U/mL. Three‐, 6‐, and 12‐month graft survival rates were 100%, 98.8%, and 98.8%, for patients with Factor V >0.46 U/mL, and 92.9%, 87.7%, and 87.7% for Factor V ≤0.46 U/mL. Similarly, 3‐, 6‐, and 12‐month patient survival rates were 98.8%, 96.4%, and 95.0% for patients with Factor V >0.46 U/mL, and 92.9%, 88.0%, and 82.9% for Factor V ≤0.46 U/mL. Stratification below the novel cutoff was associated with decreased graft survival at months 3 (p = 0.012), 6 (p = 0.006), and 12 (p = 0.006), and decreased patient survival at 12 months (p = 0.022).ConclusionsFactor V serves as an early biomarker for graft loss, with an optimal predictive cutoff of 0.46 U/mL in this prospective population. Validation of this new cutoff is necessary. 10.1111/ctr.70086 http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| title | Factor V Serves as an Early Biomarker for Graft Loss After Liver Transplant: A Prospective Evaluation |
| topic | Clinical Transplantation |
| url | https://onlinelibrary.wiley.com/doi/10.1111/ctr.70086 |