Advancement of Heart Transplantation in Thai Recipients: Survival Trends and Pharmacogenetic Insights
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Wiley
2025
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| author | Siwaporn Manomaisantiphap Pasawat Boon‐yasidhi Napatsanan Tanathitiphuwarat Kanokwan Thammanatsakul Sarinya Puwanant Akekarach Ariyachaipanich Supanee Sinphurmsukskul Monvasi Pachinburavan Pajaree Chariyavilaskul Sarawut Siwamogsatham Pat Ongcharit |
| author_facet | Siwaporn Manomaisantiphap Pasawat Boon‐yasidhi Napatsanan Tanathitiphuwarat Kanokwan Thammanatsakul Sarinya Puwanant Akekarach Ariyachaipanich Supanee Sinphurmsukskul Monvasi Pachinburavan Pajaree Chariyavilaskul Sarawut Siwamogsatham Pat Ongcharit Siwaporn Manomaisantiphap Pasawat Boon‐yasidhi Napatsanan Tanathitiphuwarat Kanokwan Thammanatsakul Sarinya Puwanant Akekarach Ariyachaipanich Supanee Sinphurmsukskul Monvasi Pachinburavan Pajaree Chariyavilaskul Sarawut Siwamogsatham Pat Ongcharit |
| collection | Wiley Open Access |
| contents | Advancement of Heart Transplantation in Thai Recipients: Survival Trends and Pharmacogenetic Insights Siwaporn Manomaisantiphap Pasawat Boon‐yasidhi Napatsanan Tanathitiphuwarat Kanokwan Thammanatsakul Sarinya Puwanant Akekarach Ariyachaipanich Supanee Sinphurmsukskul Monvasi Pachinburavan Pajaree Chariyavilaskul Sarawut Siwamogsatham Pat Ongcharit Clinical Transplantation ABSTRACTSince 1987, King Chulalongkorn Memorial Hospital (KCMH) has performed a substantial number of heart transplants as a specific therapy for advanced‐stage heart failure. This descriptive study aimed to analyze post‐transplant survival in the recent era compared to earlier periods and examine the pharmacogenetics of related immunosuppressants. Data from all recipients who underwent heart transplants from 1987 to 2021 were retrospectively retrieved from the electronic medical record. The genotypes of relevant pharmacogenes were analyzed in recipients who were alive during the enrollment period. Kaplan–Meier analysis revealed improved overall survival rates in the recent era compared to the past. Dilated cardiomyopathy was identified as the most common pretransplant diagnosis, while infection remained the leading cause of mortality. In conclusion, the findings demonstrate significant advancements in the quality of heart transplantation in Thailand. Future studies are warranted to explore the correlation between pharmacogenetic variations identified in this study and subsequent clinical outcomes, with a focus on genetic‐guided treatment to optimize patient care. 10.1111/ctr.70092 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/ctr.70092 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_ctr_70092 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Advancement of Heart Transplantation in Thai Recipients: Survival Trends and Pharmacogenetic Insights Siwaporn Manomaisantiphap Pasawat Boon‐yasidhi Napatsanan Tanathitiphuwarat Kanokwan Thammanatsakul Sarinya Puwanant Akekarach Ariyachaipanich Supanee Sinphurmsukskul Monvasi Pachinburavan Pajaree Chariyavilaskul Sarawut Siwamogsatham Pat Ongcharit Clinical Transplantation Advancement of Heart Transplantation in Thai Recipients: Survival Trends and Pharmacogenetic Insights Siwaporn Manomaisantiphap Pasawat Boon‐yasidhi Napatsanan Tanathitiphuwarat Kanokwan Thammanatsakul Sarinya Puwanant Akekarach Ariyachaipanich Supanee Sinphurmsukskul Monvasi Pachinburavan Pajaree Chariyavilaskul Sarawut Siwamogsatham Pat Ongcharit Clinical Transplantation ABSTRACTSince 1987, King Chulalongkorn Memorial Hospital (KCMH) has performed a substantial number of heart transplants as a specific therapy for advanced‐stage heart failure. This descriptive study aimed to analyze post‐transplant survival in the recent era compared to earlier periods and examine the pharmacogenetics of related immunosuppressants. Data from all recipients who underwent heart transplants from 1987 to 2021 were retrospectively retrieved from the electronic medical record. The genotypes of relevant pharmacogenes were analyzed in recipients who were alive during the enrollment period. Kaplan–Meier analysis revealed improved overall survival rates in the recent era compared to the past. Dilated cardiomyopathy was identified as the most common pretransplant diagnosis, while infection remained the leading cause of mortality. In conclusion, the findings demonstrate significant advancements in the quality of heart transplantation in Thailand. Future studies are warranted to explore the correlation between pharmacogenetic variations identified in this study and subsequent clinical outcomes, with a focus on genetic‐guided treatment to optimize patient care. 10.1111/ctr.70092 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Advancement of Heart Transplantation in Thai Recipients: Survival Trends and Pharmacogenetic Insights |
| topic | Clinical Transplantation |
| url | https://onlinelibrary.wiley.com/doi/10.1111/ctr.70092 |