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| Natura: | Artículo Open Access |
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Wiley
2025
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| Accesso online: | https://onlinelibrary.wiley.com/doi/10.1111/ctr.70100 |
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| author | Farid Foroutan Daniel G Rayner Shelly Oss Marco Straccia Rienk de Vries Shilpa Raju Farhin Ahmed Jennifer Kingdon Sai Bhagra Shafrina Tarani Sabina Herrera Rahima Bhanji Heather Ross Timothy Pruett Sandy Feng Marcus Pereira Coleman Rotstein Gordon Guyatt Natasha Aleksova |
| author_facet | Farid Foroutan Daniel G Rayner Shelly Oss Marco Straccia Rienk de Vries Shilpa Raju Farhin Ahmed Jennifer Kingdon Sai Bhagra Shafrina Tarani Sabina Herrera Rahima Bhanji Heather Ross Timothy Pruett Sandy Feng Marcus Pereira Coleman Rotstein Gordon Guyatt Natasha Aleksova Farid Foroutan Daniel G Rayner Shelly Oss Marco Straccia Rienk de Vries Shilpa Raju Farhin Ahmed Jennifer Kingdon Sai Bhagra Shafrina Tarani Sabina Herrera Rahima Bhanji Heather Ross Timothy Pruett Sandy Feng Marcus Pereira Coleman Rotstein Gordon Guyatt Natasha Aleksova |
| collection | Wiley Open Access |
| contents | Clinical Practice Recommendations on the Effect of COVID‐19 Vaccination Strategies on Outcomes in Solid Organ Transplant Recipients Farid Foroutan Daniel G Rayner Shelly Oss Marco Straccia Rienk de Vries Shilpa Raju Farhin Ahmed Jennifer Kingdon Sai Bhagra Shafrina Tarani Sabina Herrera Rahima Bhanji Heather Ross Timothy Pruett Sandy Feng Marcus Pereira Coleman Rotstein Gordon Guyatt Natasha Aleksova Clinical Transplantation ABSTRACTIntroductionSolid organ transplant (SOT) recipients were excluded from clinical trials evaluating the efficacy of COVID‐19 vaccines. There is uncertainty about the number of doses required to prevent life‐threatening infection, as well as uncertainty in the optimal vaccine type and their durability. Our objectives were to provide recommendations on the number of COVID‐19 vaccination doses, type of vaccine, dose of vaccine administered, and timing of vaccination in SOT recipients.MethodsWe commissioned a systematic review on COVID‐19 vaccination in SOT, focusing on patient‐important outcomes. We recruited an international, multidisciplinary panel of 18 stakeholders, including patient partners to summarize our findings using the GRADE (grading of recommendation, assessment, development, and evaluation) framework, rate certainty in the evidence, and develop recommendations.ResultsOur panel recommends the routine provision of additional COVID‐19 doses after the primary series to SOT recipients with variant‐appropriate vaccines (strong recommendation, low certainty evidence). We suggest using any available WHO‐approved vaccine rather than selectively choosing a specific type and receiving a single dose rather than a double dose of any COVID‐19 vaccine booster (weak recommendation, low certainty evidence). Lastly, we suggest vaccination before transplantation when possible (weak recommendation, low certainty evidence).ConclusionThe evidence used to guide these recommendations is limited by the paucity of robust randomized trials evaluating COVID‐19 vaccination strategies and clinical outcomes in the SOT population. The provision of higher‐quality evidence of the overall effects of COVID‐19 vaccination in SOT to inform clinical practice will require large, randomized trials. 10.1111/ctr.70100 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/ctr.70100 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_ctr_70100 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Clinical Practice Recommendations on the Effect of COVID‐19 Vaccination Strategies on Outcomes in Solid Organ Transplant Recipients Farid Foroutan Daniel G Rayner Shelly Oss Marco Straccia Rienk de Vries Shilpa Raju Farhin Ahmed Jennifer Kingdon Sai Bhagra Shafrina Tarani Sabina Herrera Rahima Bhanji Heather Ross Timothy Pruett Sandy Feng Marcus Pereira Coleman Rotstein Gordon Guyatt Natasha Aleksova Clinical Transplantation Clinical Practice Recommendations on the Effect of COVID‐19 Vaccination Strategies on Outcomes in Solid Organ Transplant Recipients Farid Foroutan Daniel G Rayner Shelly Oss Marco Straccia Rienk de Vries Shilpa Raju Farhin Ahmed Jennifer Kingdon Sai Bhagra Shafrina Tarani Sabina Herrera Rahima Bhanji Heather Ross Timothy Pruett Sandy Feng Marcus Pereira Coleman Rotstein Gordon Guyatt Natasha Aleksova Clinical Transplantation ABSTRACTIntroductionSolid organ transplant (SOT) recipients were excluded from clinical trials evaluating the efficacy of COVID‐19 vaccines. There is uncertainty about the number of doses required to prevent life‐threatening infection, as well as uncertainty in the optimal vaccine type and their durability. Our objectives were to provide recommendations on the number of COVID‐19 vaccination doses, type of vaccine, dose of vaccine administered, and timing of vaccination in SOT recipients.MethodsWe commissioned a systematic review on COVID‐19 vaccination in SOT, focusing on patient‐important outcomes. We recruited an international, multidisciplinary panel of 18 stakeholders, including patient partners to summarize our findings using the GRADE (grading of recommendation, assessment, development, and evaluation) framework, rate certainty in the evidence, and develop recommendations.ResultsOur panel recommends the routine provision of additional COVID‐19 doses after the primary series to SOT recipients with variant‐appropriate vaccines (strong recommendation, low certainty evidence). We suggest using any available WHO‐approved vaccine rather than selectively choosing a specific type and receiving a single dose rather than a double dose of any COVID‐19 vaccine booster (weak recommendation, low certainty evidence). Lastly, we suggest vaccination before transplantation when possible (weak recommendation, low certainty evidence).ConclusionThe evidence used to guide these recommendations is limited by the paucity of robust randomized trials evaluating COVID‐19 vaccination strategies and clinical outcomes in the SOT population. The provision of higher‐quality evidence of the overall effects of COVID‐19 vaccination in SOT to inform clinical practice will require large, randomized trials. 10.1111/ctr.70100 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Clinical Practice Recommendations on the Effect of COVID‐19 Vaccination Strategies on Outcomes in Solid Organ Transplant Recipients |
| topic | Clinical Transplantation |
| url | https://onlinelibrary.wiley.com/doi/10.1111/ctr.70100 |