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| Format: | Artículo Open Access |
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Wiley
2025
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| Online Access: | https://onlinelibrary.wiley.com/doi/10.1111/ctr.70113 |
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| author | Amiti Jain Christopher Pritting Andrew Brodie Daler Rahimov Danial Ahmad J. Eduardo Rame Rene Alvarez Keshava Rajagopal John W. Entwistle Vakhtang Tchantchaleishvili |
| author_facet | Amiti Jain Christopher Pritting Andrew Brodie Daler Rahimov Danial Ahmad J. Eduardo Rame Rene Alvarez Keshava Rajagopal John W. Entwistle Vakhtang Tchantchaleishvili Amiti Jain Christopher Pritting Andrew Brodie Daler Rahimov Danial Ahmad J. Eduardo Rame Rene Alvarez Keshava Rajagopal John W. Entwistle Vakhtang Tchantchaleishvili |
| collection | Wiley Open Access |
| contents | Individual Association of Predicted Left and Right Ventricular Mass Ratios With Survival After Heart Transplantation: A UNOS Database Analysis Amiti Jain Christopher Pritting Andrew Brodie Daler Rahimov Danial Ahmad J. Eduardo Rame Rene Alvarez Keshava Rajagopal John W. Entwistle Vakhtang Tchantchaleishvili Clinical Transplantation ABSTRACTBackgroundPredicted heart mass (PHM) ratio is a commonly used metric for donor‐to‐recipient size matching that has been associated with survival after heart transplantation (HTx). PHM represents a sum of two separate statistical models for predicted left ventricular mass (PLVM) and predicted right ventricular mass (PRVM); however, their individual contributions have not been sufficiently studied. We sought to assess the association of donor‐to‐recipient PLVM (PLVMR) and PRVM ratios (PRVMR) with overall posttransplant survival individually.MethodsAdult heart transplant recipients from 2005 to 2021 were queried from the UNOS database. A three‐dimensional tensor product spline model assessed the association of PLVMR and PRVMR with survival simultaneously on a continuous distribution. Subsequently, PLVMR and PRVMR were explored individually using individual restricted cubic spline models.ResultsA total of 25 549 patients were analyzed. Of these, female recipients comprised 26.7% (n = 6818), and the median age was 56 [IQR 46–63] years. In the three‐dimensional restricted cubic spline (3D‐RCS) model, PLVMR and PRVMR were significantly associated with survival (p value: overall = 0.002, PLVMR = 0.0006, PRVMR = 0.0006, PLVMR*PRVMR = 0.0002). When analyzed with two‐dimensional restricted cubic spline (2D‐RCS) models, PLVMR was not associated with survival (p = 0.59), while PRVMR retained its significant association (p = 0.04).ConclusionWhile both PLVMR and PRVMR appear to be associated with posttransplant survival, the effect of PRVMR might be disproportionately high as PRVM makes up a much smaller fraction of PHM than PLVM. 10.1111/ctr.70113 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/ctr.70113 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_ctr_70113 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Individual Association of Predicted Left and Right Ventricular Mass Ratios With Survival After Heart Transplantation: A UNOS Database Analysis Amiti Jain Christopher Pritting Andrew Brodie Daler Rahimov Danial Ahmad J. Eduardo Rame Rene Alvarez Keshava Rajagopal John W. Entwistle Vakhtang Tchantchaleishvili Clinical Transplantation Individual Association of Predicted Left and Right Ventricular Mass Ratios With Survival After Heart Transplantation: A UNOS Database Analysis Amiti Jain Christopher Pritting Andrew Brodie Daler Rahimov Danial Ahmad J. Eduardo Rame Rene Alvarez Keshava Rajagopal John W. Entwistle Vakhtang Tchantchaleishvili Clinical Transplantation ABSTRACTBackgroundPredicted heart mass (PHM) ratio is a commonly used metric for donor‐to‐recipient size matching that has been associated with survival after heart transplantation (HTx). PHM represents a sum of two separate statistical models for predicted left ventricular mass (PLVM) and predicted right ventricular mass (PRVM); however, their individual contributions have not been sufficiently studied. We sought to assess the association of donor‐to‐recipient PLVM (PLVMR) and PRVM ratios (PRVMR) with overall posttransplant survival individually.MethodsAdult heart transplant recipients from 2005 to 2021 were queried from the UNOS database. A three‐dimensional tensor product spline model assessed the association of PLVMR and PRVMR with survival simultaneously on a continuous distribution. Subsequently, PLVMR and PRVMR were explored individually using individual restricted cubic spline models.ResultsA total of 25 549 patients were analyzed. Of these, female recipients comprised 26.7% (n = 6818), and the median age was 56 [IQR 46–63] years. In the three‐dimensional restricted cubic spline (3D‐RCS) model, PLVMR and PRVMR were significantly associated with survival (p value: overall = 0.002, PLVMR = 0.0006, PRVMR = 0.0006, PLVMR*PRVMR = 0.0002). When analyzed with two‐dimensional restricted cubic spline (2D‐RCS) models, PLVMR was not associated with survival (p = 0.59), while PRVMR retained its significant association (p = 0.04).ConclusionWhile both PLVMR and PRVMR appear to be associated with posttransplant survival, the effect of PRVMR might be disproportionately high as PRVM makes up a much smaller fraction of PHM than PLVM. 10.1111/ctr.70113 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Individual Association of Predicted Left and Right Ventricular Mass Ratios With Survival After Heart Transplantation: A UNOS Database Analysis |
| topic | Clinical Transplantation |
| url | https://onlinelibrary.wiley.com/doi/10.1111/ctr.70113 |