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| Format: | Artículo Open Access |
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Wiley
2025
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| Online-Zugang: | https://onlinelibrary.wiley.com/doi/10.1111/ctr.70304 |
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Inhaltsangabe:
- Correlation Between Health Literacy and Tacrolimus Variability in Solid Organ Transplant Recipients Astrid Bacle Pauline Blanc‐Petitjean Elouan Demay Sarah Pelletier Virginie Migeot Marie‐Claude Langevin Jean‐Philippe Adam Clinical Transplantation ABSTRACT Background Adherence to immunosuppressive therapy is crucial for successful outcomes in solid organ transplantation. Tacrolimus intra‐patient variability (%CV) is a validated marker of adherence and has been associated with graft outcomes. Health literacy (HL), a modifiable factor, may influence this variability, but its role remains unexplored. Methods We conducted a prospective observational study including adult kidney, liver, and lung transplant recipients receiving tacrolimus. HL was assessed using the Short Test of Functional Health Literacy in Adults (S‐TOFHLA); a score <23 indicated insufficient HL. Tacrolimus %CV was calculated over 6 months post‐discharge. Linear regression models, adjusted for sociodemographic variables, evaluated the association between HL and %CV. Results Ninety‐eight patients were included (kidney: n = 38, liver: n = 24, lung: n = 36). Patients with insufficient HL had higher %CV than those with sufficient HL (31.5% vs. 16.1%, p < 0.05). HL remained independently associated with %CV after adjusting for age and transplant type ( β = −1.60, SE = 0.17, p < 0.05). The final model explained 53% of %CV variability. Conclusions HL is independently associated with tacrolimus variability. HL screening and targeted educational interventions may help improve medication stability and long‐term transplant outcomes. 10.1111/ctr.70304 http://creativecommons.org/licenses/by-nc/4.0/