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| Natura: | Artículo Open Access |
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Wiley
2025
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| Accesso online: | https://onlinelibrary.wiley.com/doi/10.1111/ctr.70308 |
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| author | Domingo J. Franco‐Palacios Carlos R. Franco‐Palacios Sarah Crowley Lisa L. Allenspach Lisa Stagner Julio Pinto Corrales Kaitlin Olexsey Lisa Waynick Jane Simanovski Humza Bhatti Ryann Laier Adele Myszenski Yichu Wang Mei Lu Thomas Song |
| author_facet | Domingo J. Franco‐Palacios Carlos R. Franco‐Palacios Sarah Crowley Lisa L. Allenspach Lisa Stagner Julio Pinto Corrales Kaitlin Olexsey Lisa Waynick Jane Simanovski Humza Bhatti Ryann Laier Adele Myszenski Yichu Wang Mei Lu Thomas Song Domingo J. Franco‐Palacios Carlos R. Franco‐Palacios Sarah Crowley Lisa L. Allenspach Lisa Stagner Julio Pinto Corrales Kaitlin Olexsey Lisa Waynick Jane Simanovski Humza Bhatti Ryann Laier Adele Myszenski Yichu Wang Mei Lu Thomas Song |
| collection | Wiley Open Access |
| contents | Effect of Total Psoas Muscle Area and Serum Albumin on Outcomes After Lung Transplantation Domingo J. Franco‐Palacios Carlos R. Franco‐Palacios Sarah Crowley Lisa L. Allenspach Lisa Stagner Julio Pinto Corrales Kaitlin Olexsey Lisa Waynick Jane Simanovski Humza Bhatti Ryann Laier Adele Myszenski Yichu Wang Mei Lu Thomas Song Clinical Transplantation ABSTRACT Background Sarcopenia of the psoas muscle and hypoalbuminemia indicate poor nutritional status, inflammation, and frailty in lung transplant (LT) candidates, correlating with worse post‐transplant outcomes. Methods Retrospective study of LT recipients (2015–2023) examining the association of total psoas muscle area (TPA) and serum albumin with hospital stay, survival, and pulmonary function. Results One hundred thirty‐two LT recipients (mean age 59.56 ± 10.65 years, BMI 26.73 ± 5.55 kg/m 2 , 65% males), 95% underwent bilateral LT. Higher TPA was associated with shorter hospital and ICU stays ( p = 0.001). Similarly, higher albumin levels were associated with reduced hospital and ICU stays ( p < 0.001). Hospital survivors had higher TPA (17.5 ± 6.1 vs. 14.6 ± 5.2 cm 2 , p = 0.02) and higher albumin levels (3.25 ± 0.73 vs. 2.75 ± 0.85 mg/dL, p = 0.01). Long‐term survivors had higher TPA (17.8 ± 6.35 vs. 15.9 ± 5.51 cm 2 , p = 0.07) and higher albumin levels (3.29 ± 0.75 vs. 2.97 ± 0.78 mg/dL, p = 0.01). On multivariate analysis, albumin and male gender remained independent predictors of hospital and long‐term survival. TPA was positively associated with post‐transplant pulmonary function based on FVC and FEV1 ( p < 0.001), while albumin levels showed no association. Conclusion In the present study of LT recipients, higher TPA and albumin levels were linked to shorter hospitalization, and albumin independently predicted survival. TPA, but not albumin, was associated with pulmonary function post‐transplant. 10.1111/ctr.70308 http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| doi_str_mv | 10.1111/ctr.70308 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_ctr_70308 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Effect of Total Psoas Muscle Area and Serum Albumin on Outcomes After Lung Transplantation Domingo J. Franco‐Palacios Carlos R. Franco‐Palacios Sarah Crowley Lisa L. Allenspach Lisa Stagner Julio Pinto Corrales Kaitlin Olexsey Lisa Waynick Jane Simanovski Humza Bhatti Ryann Laier Adele Myszenski Yichu Wang Mei Lu Thomas Song Clinical Transplantation Effect of Total Psoas Muscle Area and Serum Albumin on Outcomes After Lung Transplantation Domingo J. Franco‐Palacios Carlos R. Franco‐Palacios Sarah Crowley Lisa L. Allenspach Lisa Stagner Julio Pinto Corrales Kaitlin Olexsey Lisa Waynick Jane Simanovski Humza Bhatti Ryann Laier Adele Myszenski Yichu Wang Mei Lu Thomas Song Clinical Transplantation ABSTRACT Background Sarcopenia of the psoas muscle and hypoalbuminemia indicate poor nutritional status, inflammation, and frailty in lung transplant (LT) candidates, correlating with worse post‐transplant outcomes. Methods Retrospective study of LT recipients (2015–2023) examining the association of total psoas muscle area (TPA) and serum albumin with hospital stay, survival, and pulmonary function. Results One hundred thirty‐two LT recipients (mean age 59.56 ± 10.65 years, BMI 26.73 ± 5.55 kg/m 2 , 65% males), 95% underwent bilateral LT. Higher TPA was associated with shorter hospital and ICU stays ( p = 0.001). Similarly, higher albumin levels were associated with reduced hospital and ICU stays ( p < 0.001). Hospital survivors had higher TPA (17.5 ± 6.1 vs. 14.6 ± 5.2 cm 2 , p = 0.02) and higher albumin levels (3.25 ± 0.73 vs. 2.75 ± 0.85 mg/dL, p = 0.01). Long‐term survivors had higher TPA (17.8 ± 6.35 vs. 15.9 ± 5.51 cm 2 , p = 0.07) and higher albumin levels (3.29 ± 0.75 vs. 2.97 ± 0.78 mg/dL, p = 0.01). On multivariate analysis, albumin and male gender remained independent predictors of hospital and long‐term survival. TPA was positively associated with post‐transplant pulmonary function based on FVC and FEV1 ( p < 0.001), while albumin levels showed no association. Conclusion In the present study of LT recipients, higher TPA and albumin levels were linked to shorter hospitalization, and albumin independently predicted survival. TPA, but not albumin, was associated with pulmonary function post‐transplant. 10.1111/ctr.70308 http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| title | Effect of Total Psoas Muscle Area and Serum Albumin on Outcomes After Lung Transplantation |
| topic | Clinical Transplantation |
| url | https://onlinelibrary.wiley.com/doi/10.1111/ctr.70308 |