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| Main Authors: | , , , , , , , , , , |
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| Format: | Artículo Open Access |
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Wiley
2025
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| Online Access: | https://onlinelibrary.wiley.com/doi/10.1111/ctr.70322 |
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| author | Naydeen Mostafa Omar Almaadawy Ahmed Elshahat Muhiddin Dervis Belal Mohamed Hamed Amar Asad Sofian Zreigh Esraa M. Soliman Hamed Abdelma'aboud Mostafa Hossam Elbenawi Mustafa Ahmed |
| author_facet | Naydeen Mostafa Omar Almaadawy Ahmed Elshahat Muhiddin Dervis Belal Mohamed Hamed Amar Asad Sofian Zreigh Esraa M. Soliman Hamed Abdelma'aboud Mostafa Hossam Elbenawi Mustafa Ahmed Naydeen Mostafa Omar Almaadawy Ahmed Elshahat Muhiddin Dervis Belal Mohamed Hamed Amar Asad Sofian Zreigh Esraa M. Soliman Hamed Abdelma'aboud Mostafa Hossam Elbenawi Mustafa Ahmed |
| collection | Wiley Open Access |
| contents | Predictors and Prognosis of Right Bundle Branch Block Following Heart Transplantation: A Systematic Review and Meta‐Analysis Naydeen Mostafa Omar Almaadawy Ahmed Elshahat Muhiddin Dervis Belal Mohamed Hamed Amar Asad Sofian Zreigh Esraa M. Soliman Hamed Abdelma'aboud Mostafa Hossam Elbenawi Mustafa Ahmed Clinical Transplantation ABSTRACT Background Right bundle branch block (RBBB) has a high prevalence among heart transplant recipients and could influence outcomes. Crucially, the predictors of RBBB development after heart transplantation are not well‐established. Our study aims to evaluate the preoperative predictors and outcomes of RBBB following heart transplantation. Methods PubMed, Scopus, Web of Science, and Cochrane Library were searched up to November 15, 2024, to identify studies comparing heart transplant recipients with RBBB and without RBBB. Random‐effects models were used to estimate the pooled mean difference (MD) and risk ratios (RRs) with 95% confidence intervals (95% CIs). Results Nine studies incorporating 1507 patients were included. Patients who developed RBBB had higher graft ischemia time [MD: 10.0; 95% CI: 2.00–17.91; p = 0.01] and pulmonary vascular resistance (PVR) (MD: 0.44; 95% CI: 0.21–0.68; p < 0.001). There was no significant difference between RBBB and non‐RBBB patients in terms of pulmonary artery pressure (MD: 1.83; 95% CI: ‐0.86–4.53; p = 0.18) or donor age (MD: 1.51; 95% CI: ‐0.30– 3.31; p = 0.10). There was no significant difference in the prognosis of RBBB patients in terms of acute rejection (RR: 1.06; 95% CI: 0.70–1.61; p = 0.78), chronic rejection (RR: 0.92; 95% CI: 0.60–1.41; p = 0.70), or mortality (RR: 1.87; 95% CI: 0.81–4.31; p = 0.14). Conclusion Despite the association of RBBB with graft ischemia time and PVR, post‐transplant RBBB had no significant impact on mortality or graft rejection. Further research focusing on the identification period and applied definition of RBBB is recommended. 10.1111/ctr.70322 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/ctr.70322 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_ctr_70322 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Predictors and Prognosis of Right Bundle Branch Block Following Heart Transplantation: A Systematic Review and Meta‐Analysis Naydeen Mostafa Omar Almaadawy Ahmed Elshahat Muhiddin Dervis Belal Mohamed Hamed Amar Asad Sofian Zreigh Esraa M. Soliman Hamed Abdelma'aboud Mostafa Hossam Elbenawi Mustafa Ahmed Clinical Transplantation Predictors and Prognosis of Right Bundle Branch Block Following Heart Transplantation: A Systematic Review and Meta‐Analysis Naydeen Mostafa Omar Almaadawy Ahmed Elshahat Muhiddin Dervis Belal Mohamed Hamed Amar Asad Sofian Zreigh Esraa M. Soliman Hamed Abdelma'aboud Mostafa Hossam Elbenawi Mustafa Ahmed Clinical Transplantation ABSTRACT Background Right bundle branch block (RBBB) has a high prevalence among heart transplant recipients and could influence outcomes. Crucially, the predictors of RBBB development after heart transplantation are not well‐established. Our study aims to evaluate the preoperative predictors and outcomes of RBBB following heart transplantation. Methods PubMed, Scopus, Web of Science, and Cochrane Library were searched up to November 15, 2024, to identify studies comparing heart transplant recipients with RBBB and without RBBB. Random‐effects models were used to estimate the pooled mean difference (MD) and risk ratios (RRs) with 95% confidence intervals (95% CIs). Results Nine studies incorporating 1507 patients were included. Patients who developed RBBB had higher graft ischemia time [MD: 10.0; 95% CI: 2.00–17.91; p = 0.01] and pulmonary vascular resistance (PVR) (MD: 0.44; 95% CI: 0.21–0.68; p < 0.001). There was no significant difference between RBBB and non‐RBBB patients in terms of pulmonary artery pressure (MD: 1.83; 95% CI: ‐0.86–4.53; p = 0.18) or donor age (MD: 1.51; 95% CI: ‐0.30– 3.31; p = 0.10). There was no significant difference in the prognosis of RBBB patients in terms of acute rejection (RR: 1.06; 95% CI: 0.70–1.61; p = 0.78), chronic rejection (RR: 0.92; 95% CI: 0.60–1.41; p = 0.70), or mortality (RR: 1.87; 95% CI: 0.81–4.31; p = 0.14). Conclusion Despite the association of RBBB with graft ischemia time and PVR, post‐transplant RBBB had no significant impact on mortality or graft rejection. Further research focusing on the identification period and applied definition of RBBB is recommended. 10.1111/ctr.70322 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Predictors and Prognosis of Right Bundle Branch Block Following Heart Transplantation: A Systematic Review and Meta‐Analysis |
| topic | Clinical Transplantation |
| url | https://onlinelibrary.wiley.com/doi/10.1111/ctr.70322 |