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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Artículo Open Access |
| Published: |
Wiley
2025
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| Subjects: | |
| Online Access: | https://onlinelibrary.wiley.com/doi/10.1111/ctr.70359 |
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Table of Contents:
- The Eastern Cooperative Oncology Group Score Rather Than Donor Type Impacts Clinical Outcomes of Allogeneic Hematopoietic Stem Cell Transplantation in Severe Aplastic Anemia Patients Aged 51–60 Years: A Retrospective Study From the Chinese Blood and Marrow Transplant Registry Xin Zhao Ming Zhou Bao‐Dong Ye Er‐Lie Jiang Dai‐Hong Liu Peihua Lu Fang Zhou Gui‐Fang Ou‐Yang Ya‐Jing Xu Xin Li Wei‐Wei Qin Hai Yi Guan‐Chen Bai Zi‐Min Sun Xue‐Jun Zhang Xue‐Hong Ran Jian‐Ping Zhang Guo‐Hong Su Jin‐Xiong Huang Tai‐Wu Xiao Xian‐Min Song Hui‐Xia Liu Jin‐Song Yan Ke‐Hong Bi Xi Zhang Xiao‐Jun Huang Shun‐Qing Wang Lan‐Ping Xu Clinical Transplantation ABSTRACT Our study includes 103 patients aged between 51 and 60 years who underwent allogeneic hematopoietic stem cell transplantation (allo‐HSCT) from matched sibling donors (MSDs) ( n = 36), haploidentical donors (HIDs) ( n = 56), and unrelated donors (URDs) ( n = 11). Multivariate analysis exploring the relationship between risk factors and survival confirmed that survival outcomes were only independently impacted by Eastern Cooperative Oncology Group (ECOG) score (ECOG scores ≥2 vs. ECOG scores of 0–1, overall survival [OS] HR: 2.91 [95% CI 1.35–6.27], p = 0.006; failure free survival [FFS] HR: 2.93 [95% CI 1.33–5.88], p = 0.006; graft‐versus‐host disease–free/relapse‐free survival [GRFS] HR: 2.80 [95% CI 1.33–5.88], p = 0.006), while age, specific donor source and hematopoietic cell transplantation‐comorbidity index (HCT‐CI) score did not significantly influence prognosis in this age group. After applying propensity score‐matching (PSM) to balance the pretransplant clinical factors between patients with ECOG scores 0–1 cohort and those with ECOG scores ≥2 cohort, poor performance status remains a negative factor for survival outcomes (OS p = 0.04; FFS p = 0.03; GRFS p = 0.03). Further analysis in subgroup patients with HCT‐CI scores 0–1 found the retained significance of ECOG score in predicting inferior survival. In conclusion, our results indicate good long‐term results of allo‐HSCT in elderly SAA adults regardless of donor type. Higher ECOG score is associated with poor post‐transplant outcomes and has to be taken into account for patients, even at a low‐risk comorbidly burden. 10.1111/ctr.70359 http://onlinelibrary.wiley.com/termsAndConditions#vor