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| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Artículo Open Access |
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Wiley
2026
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| Online Access: | https://onlinelibrary.wiley.com/doi/10.1111/ctr.70547 |
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Table of Contents:
- A Retrospective Multicenter Study Identifies a Similar Overall Survival of Patients After Liver Transplantation With Incidental Cholangiocarcinoma Compared to Hepatocellular Carcinoma Sophia Heinrich Alejandro Campos‐Murguia Angelina Mensah Kateryna Shmanko Dionysios Koliogiannis Kathrin H. Vollmann Simone C. Boedecker‐Lips Bernd Heinrich Theresa Kirchner Bastian Engel Christian M. Lange Arndt Weinmann Jens Mittler Thomas C. Wirth Anna Saborowski Heiner Wedemeyer Richard Taubert Clinical Transplantation ABSTRACT Background Cholangiocarcinoma (CCA) is the second most common liver malignancy with a dismal prognosis. Liver transplantation of patients with CCA is currently no treatment option backed by guidelines for most of the patients, mainly because of presumably worse outcome. This study identified cases of incidental CCA (incCCA) in three German transplant centers, that is, CCAs unexpectedly found in liver explants, and analyzed the outcome in comparison to patients transplanted because of hepatocellular carcinoma (HCC). Methods Histopathology reports of liver explants from patients transplanted between 2002 and 2021 in three transplant centers (Hanover, Mainz, and Munich) were screened. Cases of incidental biliary tract cancer were classified according to tumor node metastasis (TNM) staging and anatomic location. Overall (OS) and disease‐free survival (DFS) were analyzed and compared to patients transplanted due to HCC fulfilling the Milan criteria. Results A total of 19 incCCA and 140 HCC patients were included in this analysis. IncCCA was a rare finding in liver explants and occurred most frequently in patients with primary sclerosing cholangitis (63%). Mean follow‐up of CCA patients was 61 (range, 4–254) months. Interestingly, OS and DFS of incCCA patients were not significantly different from patients transplanted with HCC (OS: p = 0.31; DFS p = 0.25). However, OS and DFS of incCCA patients differed significantly based on tumor location (OS HCC: N/A, intrahepatic CCA/perihilar CCA: 133 months, distal CCA/gallbladder: 6.5 months; p = 0.005; DFS HCC: 146 months, intrahepatic CCA/perihilar CCA: 133 months, distal CCA/gallbladder 5 months; p = 0.006). Conclusion OS of patients diagnosed with incCCA was similar to HCC patients. These results add data to support transplantation of specific CCA patients as a reasonable treatment option. 10.1111/ctr.70547 http://creativecommons.org/licenses/by/4.0/