The association between inflammation and glucose levels in hospitalised patients with type 2 diabetes
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2025
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| author | Mikkel T. Olsen Signe H. Jensen Louise M. Rasmussen Carina K. Klarskov Birgitte Lindegaard Jonas A. Andersen Hans Gottlieb Suzanne Lunding Kirsten Nørgaard Ulrik Pedersen‐Bjergaard Katrine B. Hansen Peter L. Kristensen |
| author_facet | Mikkel T. Olsen Signe H. Jensen Louise M. Rasmussen Carina K. Klarskov Birgitte Lindegaard Jonas A. Andersen Hans Gottlieb Suzanne Lunding Kirsten Nørgaard Ulrik Pedersen‐Bjergaard Katrine B. Hansen Peter L. Kristensen Mikkel T. Olsen Signe H. Jensen Louise M. Rasmussen Carina K. Klarskov Birgitte Lindegaard Jonas A. Andersen Hans Gottlieb Suzanne Lunding Kirsten Nørgaard Ulrik Pedersen‐Bjergaard Katrine B. Hansen Peter L. Kristensen |
| collection | Wiley Open Access |
| contents | The association between inflammation and glucose levels in hospitalised patients with type 2 diabetes Mikkel T. Olsen Signe H. Jensen Louise M. Rasmussen Carina K. Klarskov Birgitte Lindegaard Jonas A. Andersen Hans Gottlieb Suzanne Lunding Kirsten Nørgaard Ulrik Pedersen‐Bjergaard Katrine B. Hansen Peter L. Kristensen Diabetes, Obesity and Metabolism Abstract Aims Stress‐induced hyperglycaemia can exacerbate existing diabetes. However, the relationship between inpatient inflammation and glucose levels is not well understood. Materials and Methods This post hoc analysis utilised data from the DIATEC trial ( N = 166), a two‐arm randomised controlled trial comparing glucose management with real‐time continuous glucose monitoring (CGM) or point‐of‐care glucose testing in non‐intensive care unit (non‐ICU) patients with type 2 diabetes treated with a basal‐bolus insulin regimen. Inflammation was measured as C‐reactive protein (CRP) levels daily, and its association with daily glycaemic outcomes and insulin doses was assessed. Results For every 100 mg/dL increase in CRP, time in range 3.9–10.0 mmol/L (70–180 mg/dL) decreased by 3.6%‐points (95% CI: 1.2–6.1, p = 0.004). An interaction was found between high CRP (>75.0 mg/dL) and high HbA1c (>51.0 mmol/mol or 6.8%), associated with an 8.9%‐point reduction in TIR (95% CI: 3.8–14.1). Time above range >10.0 mmol/L (>180 mg/dL) increased by 3.3%‐points (95% CI: 0.8–5.8, p = 0.009), and mean glucose increased by 0.2 mmol/L (95% CI: 0.02–0.4) (4.0 mg/dL, 95% CI: 0.4–7.0) for every 100 mg/dL increase in CRP. No significant associations were found between CRP and time below range <3.9 mmol/L (<70 mg/dL), glycaemic variability, hypoglycaemic events, or total daily insulin dose (all p > 0.05). Conclusions Elevated CRP levels only modestly increased glucose levels. This suggests that inflammation during hospitalisation has a limited effect on glucose levels in non‐ICU patients with type 2 diabetes. 10.1111/dom.16640 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/dom.16640 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_dom_16640 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | The association between inflammation and glucose levels in hospitalised patients with type 2 diabetes Mikkel T. Olsen Signe H. Jensen Louise M. Rasmussen Carina K. Klarskov Birgitte Lindegaard Jonas A. Andersen Hans Gottlieb Suzanne Lunding Kirsten Nørgaard Ulrik Pedersen‐Bjergaard Katrine B. Hansen Peter L. Kristensen Diabetes, Obesity and Metabolism The association between inflammation and glucose levels in hospitalised patients with type 2 diabetes Mikkel T. Olsen Signe H. Jensen Louise M. Rasmussen Carina K. Klarskov Birgitte Lindegaard Jonas A. Andersen Hans Gottlieb Suzanne Lunding Kirsten Nørgaard Ulrik Pedersen‐Bjergaard Katrine B. Hansen Peter L. Kristensen Diabetes, Obesity and Metabolism Abstract Aims Stress‐induced hyperglycaemia can exacerbate existing diabetes. However, the relationship between inpatient inflammation and glucose levels is not well understood. Materials and Methods This post hoc analysis utilised data from the DIATEC trial ( N = 166), a two‐arm randomised controlled trial comparing glucose management with real‐time continuous glucose monitoring (CGM) or point‐of‐care glucose testing in non‐intensive care unit (non‐ICU) patients with type 2 diabetes treated with a basal‐bolus insulin regimen. Inflammation was measured as C‐reactive protein (CRP) levels daily, and its association with daily glycaemic outcomes and insulin doses was assessed. Results For every 100 mg/dL increase in CRP, time in range 3.9–10.0 mmol/L (70–180 mg/dL) decreased by 3.6%‐points (95% CI: 1.2–6.1, p = 0.004). An interaction was found between high CRP (>75.0 mg/dL) and high HbA1c (>51.0 mmol/mol or 6.8%), associated with an 8.9%‐point reduction in TIR (95% CI: 3.8–14.1). Time above range >10.0 mmol/L (>180 mg/dL) increased by 3.3%‐points (95% CI: 0.8–5.8, p = 0.009), and mean glucose increased by 0.2 mmol/L (95% CI: 0.02–0.4) (4.0 mg/dL, 95% CI: 0.4–7.0) for every 100 mg/dL increase in CRP. No significant associations were found between CRP and time below range <3.9 mmol/L (<70 mg/dL), glycaemic variability, hypoglycaemic events, or total daily insulin dose (all p > 0.05). Conclusions Elevated CRP levels only modestly increased glucose levels. This suggests that inflammation during hospitalisation has a limited effect on glucose levels in non‐ICU patients with type 2 diabetes. 10.1111/dom.16640 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | The association between inflammation and glucose levels in hospitalised patients with type 2 diabetes |
| topic | Diabetes, Obesity and Metabolism |
| url | https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.16640 |