Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Artículo Open Access |
| Published: |
Wiley
2024
|
| Subjects: | |
| Online Access: | https://onlinelibrary.wiley.com/doi/10.1111/echo.15813 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1867007837458137088 |
|---|---|
| author | Serhan Özyıldırım Baris Guven Mehmet Tugay Yumuk Hasan Ali Barman Omer Dogan Cagdas Topel Adem Atici Ayça Donmez Mehmet Serdar Kucukoglu Sait Mesut Dogan |
| author_facet | Serhan Özyıldırım Baris Guven Mehmet Tugay Yumuk Hasan Ali Barman Omer Dogan Cagdas Topel Adem Atici Ayça Donmez Mehmet Serdar Kucukoglu Sait Mesut Dogan Serhan Özyıldırım Baris Guven Mehmet Tugay Yumuk Hasan Ali Barman Omer Dogan Cagdas Topel Adem Atici Ayça Donmez Mehmet Serdar Kucukoglu Sait Mesut Dogan |
| collection | Wiley Open Access |
| contents | Evaluation of left ventricular function in patients with mitral annular disjunction using speckle tracking echocardiography Serhan Özyıldırım Baris Guven Mehmet Tugay Yumuk Hasan Ali Barman Omer Dogan Cagdas Topel Adem Atici Ayça Donmez Mehmet Serdar Kucukoglu Sait Mesut Dogan Echocardiography AbstractBackgroundMitral annular disjunction (MAD) is a structural abnormality characterized by the systolic detachment of the posterior mitral annulus and the ventricular myocardium. It is usually observed coexistent with mitral valve prolapse (MVP) and associated with a mechanical dysfunction despite preserved electrical isolation function of the mitral annulus. This study aimed to evaluate left ventricular (LV) function using speckle tracking echocardiography in MVP patients with MAD.MethodsThis study was designed as a prospective, single‐center study including 103 patients with MVP and 40 age‐ and sex‐matched control subjects. Transthoracic echocardiography and cardiac magnetic resonance imaging were performed to assess LV function and MAD presence.ResultsMAD (+) MVP (n = 34), MAD (−) MVP (n = 69), and control (n = 40) groups were enrolled in the study. Among the MVP patients, 34 (33%) had MAD. T‐negativity in the inferior leads on electrocardiography was more frequent in the MAD (+) group than in the MAD (−) patients (4.3% vs. 20.6%, p = .014). Mitral regurgitation degree, Pickelhaube sign (17.6% vs. 1.4%, p = .005), and late gadolinium enhancement frequency (35.3% vs. 10.6%, p = .002) were significantly higher in MAD (+) patients. MAD (+) patients had significantly impaired global longitudinal strain (−23.1 ± 2.1 vs. −23.5 ± 2.3, p < .001), basal longitudinal strain (BLS) (−19.6 ± 1.5 vs. −20.5 ± 1.9, p < .001), Mid‐Ventricular Longitudinal Strain (−22.2 ± 1.7 vs. −23.2 ± 2.2, p < .001) and LA strain (−24.5 ± 3.9 vs. −27.2 ± 3.6, p < .001) when compared to MAD (−) MVP patients, despite similar LV ejection fraction. All these values of MVP patients were also significantly lower than the control group. The mean MAD distance was 7.8 ± 3.2 mm in MAD (+) patients. Patients with two or more symptoms were higher in the MAD (+) group than in the MAD (−) group (4.3% vs. 44.1%, p < .001).ConclusionThis study demonstrated a significant decrease in longitudinal strain in MVP patients with MAD, indicating myocardial dysfunction. These findings suggest that MAD may contribute to LV dysfunction and highlight the importance of early detection in younger patients. Further research is needed to explore the functional implications and long‐term outcomes of MAD. 10.1111/echo.15813 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/echo.15813 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_echo_15813 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Evaluation of left ventricular function in patients with mitral annular disjunction using speckle tracking echocardiography Serhan Özyıldırım Baris Guven Mehmet Tugay Yumuk Hasan Ali Barman Omer Dogan Cagdas Topel Adem Atici Ayça Donmez Mehmet Serdar Kucukoglu Sait Mesut Dogan Echocardiography Evaluation of left ventricular function in patients with mitral annular disjunction using speckle tracking echocardiography Serhan Özyıldırım Baris Guven Mehmet Tugay Yumuk Hasan Ali Barman Omer Dogan Cagdas Topel Adem Atici Ayça Donmez Mehmet Serdar Kucukoglu Sait Mesut Dogan Echocardiography AbstractBackgroundMitral annular disjunction (MAD) is a structural abnormality characterized by the systolic detachment of the posterior mitral annulus and the ventricular myocardium. It is usually observed coexistent with mitral valve prolapse (MVP) and associated with a mechanical dysfunction despite preserved electrical isolation function of the mitral annulus. This study aimed to evaluate left ventricular (LV) function using speckle tracking echocardiography in MVP patients with MAD.MethodsThis study was designed as a prospective, single‐center study including 103 patients with MVP and 40 age‐ and sex‐matched control subjects. Transthoracic echocardiography and cardiac magnetic resonance imaging were performed to assess LV function and MAD presence.ResultsMAD (+) MVP (n = 34), MAD (−) MVP (n = 69), and control (n = 40) groups were enrolled in the study. Among the MVP patients, 34 (33%) had MAD. T‐negativity in the inferior leads on electrocardiography was more frequent in the MAD (+) group than in the MAD (−) patients (4.3% vs. 20.6%, p = .014). Mitral regurgitation degree, Pickelhaube sign (17.6% vs. 1.4%, p = .005), and late gadolinium enhancement frequency (35.3% vs. 10.6%, p = .002) were significantly higher in MAD (+) patients. MAD (+) patients had significantly impaired global longitudinal strain (−23.1 ± 2.1 vs. −23.5 ± 2.3, p < .001), basal longitudinal strain (BLS) (−19.6 ± 1.5 vs. −20.5 ± 1.9, p < .001), Mid‐Ventricular Longitudinal Strain (−22.2 ± 1.7 vs. −23.2 ± 2.2, p < .001) and LA strain (−24.5 ± 3.9 vs. −27.2 ± 3.6, p < .001) when compared to MAD (−) MVP patients, despite similar LV ejection fraction. All these values of MVP patients were also significantly lower than the control group. The mean MAD distance was 7.8 ± 3.2 mm in MAD (+) patients. Patients with two or more symptoms were higher in the MAD (+) group than in the MAD (−) group (4.3% vs. 44.1%, p < .001).ConclusionThis study demonstrated a significant decrease in longitudinal strain in MVP patients with MAD, indicating myocardial dysfunction. These findings suggest that MAD may contribute to LV dysfunction and highlight the importance of early detection in younger patients. Further research is needed to explore the functional implications and long‐term outcomes of MAD. 10.1111/echo.15813 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Evaluation of left ventricular function in patients with mitral annular disjunction using speckle tracking echocardiography |
| topic | Echocardiography |
| url | https://onlinelibrary.wiley.com/doi/10.1111/echo.15813 |