Impaired Aortic Biomechanical Properties in Patients With Severe Obstructive Sleep Apnea Syndrome
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Wiley
2025
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| author | Li Yu Zurong Yang Zhang Ming Qichang Zhou Shi Zeng |
| author_facet | Li Yu Zurong Yang Zhang Ming Qichang Zhou Shi Zeng Li Yu Zurong Yang Zhang Ming Qichang Zhou Shi Zeng |
| collection | Wiley Open Access |
| contents | Impaired Aortic Biomechanical Properties in Patients With Severe Obstructive Sleep Apnea Syndrome Li Yu Zurong Yang Zhang Ming Qichang Zhou Shi Zeng Echocardiography ABSTRACTPurposeEvaluating the biomechanical properties of the aorta is crucial for assessing cardiovascular risk and preventing disease progression. The aim of this study was to evaluate the biomechanical properties of the ascending aorta (AA) in severe obstructive sleep apnea syndrome (OSAS) patients with or without hypertension (HT) via velocity vector imaging (VVI).MethodsA total of 68 patients with severe OSAS were selected, 35 of whom were included in the simple OSAS group and 33 of whom were included in the OSAS + HT group, and 40 volunteers without these two disorders who were taken as the control group. AA biomechanical properties, that is, AA longitudinal strain (ALS), AA circumferential strain (ACS), and fractional area change (FAC), were evaluated via VVI. Pulsed Doppler early transmitral peak flow velocity (E), early diastolic mitral annular velocity (e’), left ventricular (LV) global longitudinal strain (GLS), and the AA dimension (AD) were also measured.ResultsALS (mean ± SD; 32.8% ± 11.9% and 19.7% ± 7.6% vs. 40.6% ± 15.6%, p = 0.006), ACS (mean ± SD; 11.8% ± 3.5% and 8.6% ± 2.7% vs. 16.5% ± 5.8%, p = 0.02), and FAC (mean ± SD; 21.0% ± 5.3% and 12.4% ± 3.8% vs. 32.8% ± 9.7%, p = 0.004) were significantly lower in the patient groups (OSAS and OSAS + HT, respectively) than in the control group. LV systolic and diastolic functions were also impaired in the patient groups. Compared with volunteers without OSAS and HT, these patients had a greater AD and E/e’ ratio and a lower GLS (p < 0.01). The aortic biomechanical properties were strongly correlated with the LV function and sleep parameters.ConclusionAA biomechanical properties are impaired in patients with severe OSAS, especially those with HT. Impairments in these aortic biomechanical properties are associated with diminished LV function and abnormal sleep parameters. This discovery may help clinicians identify and manage potential cardiovascular risks in OSAS patients. Further large‐scale longitudinal studies are needed to confirm the potential predictive value of aortic events (e.g., aortic aneurysm or dissection) in patients with OSAS. 10.1111/echo.70135 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/echo.70135 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_echo_70135 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Impaired Aortic Biomechanical Properties in Patients With Severe Obstructive Sleep Apnea Syndrome Li Yu Zurong Yang Zhang Ming Qichang Zhou Shi Zeng Echocardiography Impaired Aortic Biomechanical Properties in Patients With Severe Obstructive Sleep Apnea Syndrome Li Yu Zurong Yang Zhang Ming Qichang Zhou Shi Zeng Echocardiography ABSTRACTPurposeEvaluating the biomechanical properties of the aorta is crucial for assessing cardiovascular risk and preventing disease progression. The aim of this study was to evaluate the biomechanical properties of the ascending aorta (AA) in severe obstructive sleep apnea syndrome (OSAS) patients with or without hypertension (HT) via velocity vector imaging (VVI).MethodsA total of 68 patients with severe OSAS were selected, 35 of whom were included in the simple OSAS group and 33 of whom were included in the OSAS + HT group, and 40 volunteers without these two disorders who were taken as the control group. AA biomechanical properties, that is, AA longitudinal strain (ALS), AA circumferential strain (ACS), and fractional area change (FAC), were evaluated via VVI. Pulsed Doppler early transmitral peak flow velocity (E), early diastolic mitral annular velocity (e’), left ventricular (LV) global longitudinal strain (GLS), and the AA dimension (AD) were also measured.ResultsALS (mean ± SD; 32.8% ± 11.9% and 19.7% ± 7.6% vs. 40.6% ± 15.6%, p = 0.006), ACS (mean ± SD; 11.8% ± 3.5% and 8.6% ± 2.7% vs. 16.5% ± 5.8%, p = 0.02), and FAC (mean ± SD; 21.0% ± 5.3% and 12.4% ± 3.8% vs. 32.8% ± 9.7%, p = 0.004) were significantly lower in the patient groups (OSAS and OSAS + HT, respectively) than in the control group. LV systolic and diastolic functions were also impaired in the patient groups. Compared with volunteers without OSAS and HT, these patients had a greater AD and E/e’ ratio and a lower GLS (p < 0.01). The aortic biomechanical properties were strongly correlated with the LV function and sleep parameters.ConclusionAA biomechanical properties are impaired in patients with severe OSAS, especially those with HT. Impairments in these aortic biomechanical properties are associated with diminished LV function and abnormal sleep parameters. This discovery may help clinicians identify and manage potential cardiovascular risks in OSAS patients. Further large‐scale longitudinal studies are needed to confirm the potential predictive value of aortic events (e.g., aortic aneurysm or dissection) in patients with OSAS. 10.1111/echo.70135 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Impaired Aortic Biomechanical Properties in Patients With Severe Obstructive Sleep Apnea Syndrome |
| topic | Echocardiography |
| url | https://onlinelibrary.wiley.com/doi/10.1111/echo.70135 |