Cardiac Structure and Function Among Patients With Heart Failure With Reduced Ejection Fraction and Kidney Disease
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Wiley
2025
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| author | Ali Hikmat Al‐Rubai Jacob Christensen Filip Soeskov Davidovski Caroline Espersen Morten Sengeløv Peter Godsk Jørgensen Manan Pareek Niels Eske Bruun Thomas Fritz‐Hansen Cecilie Johnsen Tor Biering‐Sørensen |
| author_facet | Ali Hikmat Al‐Rubai Jacob Christensen Filip Soeskov Davidovski Caroline Espersen Morten Sengeløv Peter Godsk Jørgensen Manan Pareek Niels Eske Bruun Thomas Fritz‐Hansen Cecilie Johnsen Tor Biering‐Sørensen Ali Hikmat Al‐Rubai Jacob Christensen Filip Soeskov Davidovski Caroline Espersen Morten Sengeløv Peter Godsk Jørgensen Manan Pareek Niels Eske Bruun Thomas Fritz‐Hansen Cecilie Johnsen Tor Biering‐Sørensen |
| collection | Wiley Open Access |
| contents | Cardiac Structure and Function Among Patients With Heart Failure With Reduced Ejection Fraction and Kidney Disease Ali Hikmat Al‐Rubai Jacob Christensen Filip Soeskov Davidovski Caroline Espersen Morten Sengeløv Peter Godsk Jørgensen Manan Pareek Niels Eske Bruun Thomas Fritz‐Hansen Cecilie Johnsen Tor Biering‐Sørensen Echocardiography ABSTRACT Background Kidney disease (KD) is a common comorbidity of heart failure with reduced ejection fraction (HFrEF). In this retrospective study, we sought to investigate measures of cardiac structure and function in relation to prevalent and incident kidney failure in subjects with HFrEF. Methods Subjects with a left ventricular ejection fraction (LVEF) ≤ 45% were included retrospectively from a large HF clinic. Patients were stratified into three groups: (1) no KD at baseline or during follow‐up, (2) incident KD during follow‐up, (3) prevalent KD. Echocardiographic parameters included LVEF, global longitudinal strain (GLS), tricuspid annular plane systolic excursion (TAPSE), and E/e ′ ratio. Associations with incident KD were assessed using uni‐ and multivariable Cox regression. Results The final population consisted of 1138 subjects (mean age 68.1 years (SD 11.8), male sex 72.8%), of which 53 (4.7%) had prevalent KD. During a median follow‐up period of 9.9 years, 229 (21.1%) of those without KD at baseline developed KD, and the remaining 856 (75.2%) did not. At baseline, LVEF, GLS, TAPSE, and E/e ′ ratio were incrementally impaired across groups 1 through 3. While all four measures were associated with incident KD in univariable Cox regression, only LVEF ( p = 0.023), TAPSE ( p = 0.009), and E / e ′ ratio ( p = 0.041) remained significant in adjusted analysis. Conclusion Among HFrEF patients, future onset of KD and prevalent KD were increasingly associated with impaired GLS, LVEF, TAPSE, and E/e ′ ratio. Furthermore, LVEF, TAPSE, and E/e ′ ratio were independent predictors of incident KD. 10.1111/echo.70341 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/echo.70341 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_echo_70341 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Cardiac Structure and Function Among Patients With Heart Failure With Reduced Ejection Fraction and Kidney Disease Ali Hikmat Al‐Rubai Jacob Christensen Filip Soeskov Davidovski Caroline Espersen Morten Sengeløv Peter Godsk Jørgensen Manan Pareek Niels Eske Bruun Thomas Fritz‐Hansen Cecilie Johnsen Tor Biering‐Sørensen Echocardiography Cardiac Structure and Function Among Patients With Heart Failure With Reduced Ejection Fraction and Kidney Disease Ali Hikmat Al‐Rubai Jacob Christensen Filip Soeskov Davidovski Caroline Espersen Morten Sengeløv Peter Godsk Jørgensen Manan Pareek Niels Eske Bruun Thomas Fritz‐Hansen Cecilie Johnsen Tor Biering‐Sørensen Echocardiography ABSTRACT Background Kidney disease (KD) is a common comorbidity of heart failure with reduced ejection fraction (HFrEF). In this retrospective study, we sought to investigate measures of cardiac structure and function in relation to prevalent and incident kidney failure in subjects with HFrEF. Methods Subjects with a left ventricular ejection fraction (LVEF) ≤ 45% were included retrospectively from a large HF clinic. Patients were stratified into three groups: (1) no KD at baseline or during follow‐up, (2) incident KD during follow‐up, (3) prevalent KD. Echocardiographic parameters included LVEF, global longitudinal strain (GLS), tricuspid annular plane systolic excursion (TAPSE), and E/e ′ ratio. Associations with incident KD were assessed using uni‐ and multivariable Cox regression. Results The final population consisted of 1138 subjects (mean age 68.1 years (SD 11.8), male sex 72.8%), of which 53 (4.7%) had prevalent KD. During a median follow‐up period of 9.9 years, 229 (21.1%) of those without KD at baseline developed KD, and the remaining 856 (75.2%) did not. At baseline, LVEF, GLS, TAPSE, and E/e ′ ratio were incrementally impaired across groups 1 through 3. While all four measures were associated with incident KD in univariable Cox regression, only LVEF ( p = 0.023), TAPSE ( p = 0.009), and E / e ′ ratio ( p = 0.041) remained significant in adjusted analysis. Conclusion Among HFrEF patients, future onset of KD and prevalent KD were increasingly associated with impaired GLS, LVEF, TAPSE, and E/e ′ ratio. Furthermore, LVEF, TAPSE, and E/e ′ ratio were independent predictors of incident KD. 10.1111/echo.70341 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Cardiac Structure and Function Among Patients With Heart Failure With Reduced Ejection Fraction and Kidney Disease |
| topic | Echocardiography |
| url | https://onlinelibrary.wiley.com/doi/10.1111/echo.70341 |