Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Artículo Open Access |
| Published: |
Wiley
2026
|
| Subjects: | |
| Online Access: | https://onlinelibrary.wiley.com/doi/10.1111/echo.70454 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Table of Contents:
- Calibrated Integrated Backscatter Is Associated With Increased Left Ventricular Concentricity and Left Atrial Stiffness in Resistance Trained Individuals Using Anabolic‐Androgenic Steroids Florence Place Chloe Hamilton Harry Carpenter Luca J. Howard Barbara N. Morrison Neil Chester Robert Cooper Ben N. Stansfield Keith P. George Peter Angell David Oxborough Echocardiography ABSTRACT Purpose The use of Anabolic‐Androgenic Steroids (AAS) is well documented in resistance trained individuals, despite reports of myocardial inflammation and fibrosis. Calibrated integrated backscatter (ciB) is an echocardiographic technique to measure ultrasonic reflectivity of the left ventricular (LV) myocardium and is a marker for tissue characterization. This study assessed ciB in both AAS using and non‐using resistance trained individuals and documented any relationship to LV and left atrial (LA) structure and function. Methods Male ( n = 120) and female ( n = 21) resistance trained individuals (age 30 ± 7 years); current (CU; n = 95) and non‐users (NU; n = 46) of AAS were recruited. Comprehensive echocardiography with strain imaging was performed. ciB was measured from a parasternal long axis and LA stiffness index (E/E′/LA reservoir strain) and left atrioventricular coupling index (LA end‐diastolic volume/LV end‐diastolic volume) were calculated. Results ciB was significantly higher in CU (–19.54 ± 4.63) than NU (–20.88 ± 3.94, p = 0.047). A significant positive correlation was observed between ciB and LV mass index (r s (139) = 0.318, p < 0.001), E/E′ (r(138) = 0.169, p = 0.043), LA conduit strain (r(135) = –0.174, p = 0.043), LA stiffness index (r s (134) = 0.246, p = 0.004), and left atrioventricular coupling index (r(134) = 0.241, p = 0.005). ciB was not associated with any LV systolic functional parameter (global longitudinal strain or ejection fraction). Conclusions Resistance trained individuals using AAS have significantly higher ciB than non‐users, suggesting differential myocardial tissue characteristics within this population. The presence of higher levels of ciB was significantly associated with LV geometry and LV diastolic function which may indicate a role of ciB in identifying early cardiac risk in this population. 10.1111/echo.70454 http://creativecommons.org/licenses/by/4.0/