Clinical Utility of Mechanical Echocardiographic Dispersion to Assess Left Ventricular Function and Ischemia or Infarction Detected by Gated 99M‐Tc Sestamibi‐SPECT
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2026
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| author | Adrian Espejel‐Guzman Alfonso Gonzalez‐Trejo Neftali Eduardo Antonio‐Villa Enrique C. Guerra Erick Alexanderson‐Rosas Nilda Espinola‐Zavaleta |
| author_facet | Adrian Espejel‐Guzman Alfonso Gonzalez‐Trejo Neftali Eduardo Antonio‐Villa Enrique C. Guerra Erick Alexanderson‐Rosas Nilda Espinola‐Zavaleta Adrian Espejel‐Guzman Alfonso Gonzalez‐Trejo Neftali Eduardo Antonio‐Villa Enrique C. Guerra Erick Alexanderson‐Rosas Nilda Espinola‐Zavaleta |
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| contents | Clinical Utility of Mechanical Echocardiographic Dispersion to Assess Left Ventricular Function and Ischemia or Infarction Detected by Gated 99M‐Tc Sestamibi‐SPECT Adrian Espejel‐Guzman Alfonso Gonzalez‐Trejo Neftali Eduardo Antonio‐Villa Enrique C. Guerra Erick Alexanderson‐Rosas Nilda Espinola‐Zavaleta Echocardiography ABSTRACT Background Coronary artery disease (CAD) remains the leading cause of morbidity and mortality worldwide. Echocardiographic assessment of left ventricular (LV) asynchrony may provide additional value for detecting ischemia or infarction. Objectives To assess the systolic and diastolic mechanical dispersion (MD) by 3D‐echocardiography and its correlation with left ventricular ejection fraction (LVEF) and ischemia or infarction by myocardial perfusion study (MPS) gated 99m‐Tc Sestamibi‐SPECT. Methods Cross‐sectional study of patients with angina. Systolic and diastolic MD were defined as the standard deviation (SD) of the time to reach minimum ventricular volume, corrected for the R–R interval. Association with LVEF was assessed with correlation and linear regression. ROC curves identified ischemia or infarction and compared with E/A ratio, TRIVI, and E/e’ ratio. Results 205 patients were studied with median age 62 (IQR: 54–69) years. 51% ( n = 104) presented ischemia or infarction. We observed a negative correlation with systolic ( r = −0.343, 95% −0.459 to −0.215; p < 0.001) and diastolic ( r = −0.184, 95% −0.314 to ‐0.047; p < 0.01) MD and MPS‐LVEF, which contributes to 8.9% and 11.8% of variance, respectively. Both parameters displayed an area under the curve (AUC) of 0.634 (95% 0.559–0.709, p < 0.001) and 0.604 (95% CI 0.527–0.679, p < 0.001) are shown to detect ischemia/infarction. In patients with transmural infarction the AUC for systolic MD improved to 0.691 (95% 0.582–0.801, p < 0.05). Conclusions Systolic and diastolic MD are useful and simple parameters for assessment of LV function and ischemia or infarction. 10.1111/echo.70481 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/echo.70481 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_echo_70481 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2026 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Clinical Utility of Mechanical Echocardiographic Dispersion to Assess Left Ventricular Function and Ischemia or Infarction Detected by Gated 99M‐Tc Sestamibi‐SPECT Adrian Espejel‐Guzman Alfonso Gonzalez‐Trejo Neftali Eduardo Antonio‐Villa Enrique C. Guerra Erick Alexanderson‐Rosas Nilda Espinola‐Zavaleta Echocardiography Clinical Utility of Mechanical Echocardiographic Dispersion to Assess Left Ventricular Function and Ischemia or Infarction Detected by Gated 99M‐Tc Sestamibi‐SPECT Adrian Espejel‐Guzman Alfonso Gonzalez‐Trejo Neftali Eduardo Antonio‐Villa Enrique C. Guerra Erick Alexanderson‐Rosas Nilda Espinola‐Zavaleta Echocardiography ABSTRACT Background Coronary artery disease (CAD) remains the leading cause of morbidity and mortality worldwide. Echocardiographic assessment of left ventricular (LV) asynchrony may provide additional value for detecting ischemia or infarction. Objectives To assess the systolic and diastolic mechanical dispersion (MD) by 3D‐echocardiography and its correlation with left ventricular ejection fraction (LVEF) and ischemia or infarction by myocardial perfusion study (MPS) gated 99m‐Tc Sestamibi‐SPECT. Methods Cross‐sectional study of patients with angina. Systolic and diastolic MD were defined as the standard deviation (SD) of the time to reach minimum ventricular volume, corrected for the R–R interval. Association with LVEF was assessed with correlation and linear regression. ROC curves identified ischemia or infarction and compared with E/A ratio, TRIVI, and E/e’ ratio. Results 205 patients were studied with median age 62 (IQR: 54–69) years. 51% ( n = 104) presented ischemia or infarction. We observed a negative correlation with systolic ( r = −0.343, 95% −0.459 to −0.215; p < 0.001) and diastolic ( r = −0.184, 95% −0.314 to ‐0.047; p < 0.01) MD and MPS‐LVEF, which contributes to 8.9% and 11.8% of variance, respectively. Both parameters displayed an area under the curve (AUC) of 0.634 (95% 0.559–0.709, p < 0.001) and 0.604 (95% CI 0.527–0.679, p < 0.001) are shown to detect ischemia/infarction. In patients with transmural infarction the AUC for systolic MD improved to 0.691 (95% 0.582–0.801, p < 0.05). Conclusions Systolic and diastolic MD are useful and simple parameters for assessment of LV function and ischemia or infarction. 10.1111/echo.70481 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Clinical Utility of Mechanical Echocardiographic Dispersion to Assess Left Ventricular Function and Ischemia or Infarction Detected by Gated 99M‐Tc Sestamibi‐SPECT |
| topic | Echocardiography |
| url | https://onlinelibrary.wiley.com/doi/10.1111/echo.70481 |