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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Artículo Open Access |
| Published: |
Wiley
2026
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| Online Access: | https://onlinelibrary.wiley.com/doi/10.1111/ene.70513 |
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Table of Contents:
- 1‐Year Clinical Outcome Post‐Myasthenic Crisis: A Multicenter Prospective Study in China Xiao Huan Ran Chen Lei Jin Yuan Wang Yafang Xu Lei Yang Caihua Xi Jianming Zheng Lijun Luo Song Yang Jianquan Shi Yanping Liu Zhe Ruan Wanlong Wu Wei Li Yaoxian Yue Yarong Li Wenji Jia Huahua Zhong Chong Yan Jie Song Jianying Xi Song Tan Qilong Jiang Zhangyu Zou Chongbo Zhao Sushan Luo European Journal of Neurology ABSTRACT Background Myasthenic crisis (MC) affects 10%–20% of myasthenia gravis patients and is life‐threatening with significant economic burden, yet its long‐term outcomes remain poorly understood. This prospective multicentre study aimed to evaluate 1‐year clinical outcomes after MC. Methods This study enrolled patients with MC between December 2018 and October 2024 and prospectively followed at 1, 2, 3, 6, and 12 months post‐MC. Outcome measures included Myasthenia Gravis Foundation of America (MGFA) postintervention status (PIS) classification at 1 year after MC, all‐cause mortality, and complications. Results The cohort comprised 277 patients with 282 MC episodes with a follow‐up duration of 29.16 ± 15.93 months. The in‐hospital mortality was 5.05% (14/277), while the all‐cause mortality was 15.16% (42/277). The leading causes of death were septic shock (35.7%) and multiple organ failure (21.4%). Among 247 patients with complete 1‐year follow‐up, 79.76% (197/247) achieved favorable outcomes. MG‐ADL scores reduced from 21.3 ± 2.1 at baseline to 5.5 ± 1.5 at 6 months, and 2.8 ± 1.1 at 1 year post‐MC ( p < 0.01). Multivariable analysis identified older age at crisis (OR 1.03, p = 0.003), thymoma comorbidity (OR 1.84, p = 0.041), higher comorbidity burden (Charlson Comorbidity Index ≥ 3, OR 2.68, p = 0.003), and prolonged ICU stay (OR 1.03, p = 0.002) as independent predictors for minimal symptom expression non‐responders. The most frequent chronic complications included infections (15.2%; predominantly fungal pathogens), gastrointestinal disorders (8.3%), and osteoporosis/fractures (5.1%). Conclusions This is the first prospective cohort study to report clinical outcomes in MG patients at post‐MC stage, highlighting the importance of disease monitoring and early intervention to improve patient‐centred care. 10.1111/ene.70513 http://creativecommons.org/licenses/by-nc-nd/4.0/