Global Prevalence of Helicobacter pylori Infection‐Associated Gastric Preneoplastic Lesions in Pediatric Patients: A Systematic Review and Meta‐Analysis
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| Format: | Artículo Open Access |
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Wiley
2025
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| author | Mohammed Awadh Abdun Lu Xu Xiao‐Ting Li Amr Mekky Maher Al Hussan Ezaldin M. I. Abuheit Chen Zhang Ishtiaq Ur Rahman Miao Yu Hafiz Muhammad Sohail Sarwar Bin‐Bin Yan Jia‐Bei Xie Bo‐Wei Liu Song‐Ze Ding |
| author_facet | Mohammed Awadh Abdun Lu Xu Xiao‐Ting Li Amr Mekky Maher Al Hussan Ezaldin M. I. Abuheit Chen Zhang Ishtiaq Ur Rahman Miao Yu Hafiz Muhammad Sohail Sarwar Bin‐Bin Yan Jia‐Bei Xie Bo‐Wei Liu Song‐Ze Ding Mohammed Awadh Abdun Lu Xu Xiao‐Ting Li Amr Mekky Maher Al Hussan Ezaldin M. I. Abuheit Chen Zhang Ishtiaq Ur Rahman Miao Yu Hafiz Muhammad Sohail Sarwar Bin‐Bin Yan Jia‐Bei Xie Bo‐Wei Liu Song‐Ze Ding |
| collection | Wiley Open Access |
| contents | Global Prevalence of Helicobacter pylori Infection‐Associated Gastric Preneoplastic Lesions in Pediatric Patients: A Systematic Review and Meta‐Analysis Mohammed Awadh Abdun Lu Xu Xiao‐Ting Li Amr Mekky Maher Al Hussan Ezaldin M. I. Abuheit Chen Zhang Ishtiaq Ur Rahman Miao Yu Hafiz Muhammad Sohail Sarwar Bin‐Bin Yan Jia‐Bei Xie Bo‐Wei Liu Song‐Ze Ding Helicobacter ABSTRACTBackgroundHelicobacter pylori (H. pylori) is the major cause of gastric mucosal precancerous lesions in adulthood, but its impact on pediatric patients remains unclear. We aimed to investigate H. pylori‐induced gastric precancerous lesions in children and adolescents globally and analyze their influencing factors for related disease management and prevention.Materials and MethodsWe conducted a comprehensive literature search in major databases to identify studies including pediatric patients with gastric precancerous lesions and H. pylori infection status. Prevalence rates were computed using random‐effects or fixed‐effect models. A stratified analysis was conducted based on location, age, universal health coverage (UHC), and publication time.ResultsAmong the 3359 relevant articles screened, 24 studies (7036 participants) met the inclusion criteria. The overall prevalence of precancerous lesions in H. pylori‐infected patients was 17.2%, in which atrophic gastritis (AG) and intestinal metaplasia (IM) were 13.5% and 3.6%, respectively. Precancerous lesion rates in infected individuals across different regions were as follows: Africa at 33.8% (AG: 32.6%), Latin America at 22.1% (AG: 17.9%, IM: 4.0%), Asia at 18.1% (AG: 12.4%, IM: 4.4%, Dysplasia: 1.2%), and Europe at 6.3% (AG: 4.3%, IM: 1.7%). Infected adolescents (> 10 years) exhibited a higher prevalence of precancerous lesions than younger children (≤ 10 years) at 14.2% (AG: 9.7%, IM: 2.9%) versus 3.4% (AG: 2.3%, IM: 1.1%), respectively. The prevalence of precancerous lesions in infected patients was higher in areas with low‐medium UHC compared with high UHC (24.0% vs. 12.5%).ConclusionsH. pylori infection causes significant gastric mucosal precancerous lesions in pediatric patients, representing a major concern for this population and a previously neglected area. Future in‐depth investigations and proper management for related disease prevention are warranted.Trial Registration PROSPERO number: CRD42023424683 10.1111/hel.70021 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/hel.70021 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_hel_70021 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Global Prevalence of Helicobacter pylori Infection‐Associated Gastric Preneoplastic Lesions in Pediatric Patients: A Systematic Review and Meta‐Analysis Mohammed Awadh Abdun Lu Xu Xiao‐Ting Li Amr Mekky Maher Al Hussan Ezaldin M. I. Abuheit Chen Zhang Ishtiaq Ur Rahman Miao Yu Hafiz Muhammad Sohail Sarwar Bin‐Bin Yan Jia‐Bei Xie Bo‐Wei Liu Song‐Ze Ding Helicobacter Global Prevalence of Helicobacter pylori Infection‐Associated Gastric Preneoplastic Lesions in Pediatric Patients: A Systematic Review and Meta‐Analysis Mohammed Awadh Abdun Lu Xu Xiao‐Ting Li Amr Mekky Maher Al Hussan Ezaldin M. I. Abuheit Chen Zhang Ishtiaq Ur Rahman Miao Yu Hafiz Muhammad Sohail Sarwar Bin‐Bin Yan Jia‐Bei Xie Bo‐Wei Liu Song‐Ze Ding Helicobacter ABSTRACTBackgroundHelicobacter pylori (H. pylori) is the major cause of gastric mucosal precancerous lesions in adulthood, but its impact on pediatric patients remains unclear. We aimed to investigate H. pylori‐induced gastric precancerous lesions in children and adolescents globally and analyze their influencing factors for related disease management and prevention.Materials and MethodsWe conducted a comprehensive literature search in major databases to identify studies including pediatric patients with gastric precancerous lesions and H. pylori infection status. Prevalence rates were computed using random‐effects or fixed‐effect models. A stratified analysis was conducted based on location, age, universal health coverage (UHC), and publication time.ResultsAmong the 3359 relevant articles screened, 24 studies (7036 participants) met the inclusion criteria. The overall prevalence of precancerous lesions in H. pylori‐infected patients was 17.2%, in which atrophic gastritis (AG) and intestinal metaplasia (IM) were 13.5% and 3.6%, respectively. Precancerous lesion rates in infected individuals across different regions were as follows: Africa at 33.8% (AG: 32.6%), Latin America at 22.1% (AG: 17.9%, IM: 4.0%), Asia at 18.1% (AG: 12.4%, IM: 4.4%, Dysplasia: 1.2%), and Europe at 6.3% (AG: 4.3%, IM: 1.7%). Infected adolescents (> 10 years) exhibited a higher prevalence of precancerous lesions than younger children (≤ 10 years) at 14.2% (AG: 9.7%, IM: 2.9%) versus 3.4% (AG: 2.3%, IM: 1.1%), respectively. The prevalence of precancerous lesions in infected patients was higher in areas with low‐medium UHC compared with high UHC (24.0% vs. 12.5%).ConclusionsH. pylori infection causes significant gastric mucosal precancerous lesions in pediatric patients, representing a major concern for this population and a previously neglected area. Future in‐depth investigations and proper management for related disease prevention are warranted.Trial Registration PROSPERO number: CRD42023424683 10.1111/hel.70021 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Global Prevalence of Helicobacter pylori Infection‐Associated Gastric Preneoplastic Lesions in Pediatric Patients: A Systematic Review and Meta‐Analysis |
| topic | Helicobacter |
| url | https://onlinelibrary.wiley.com/doi/10.1111/hel.70021 |