Development of Simplified Risk Assessment Scoring System for Sarcopenia in Patients With Chronic Liver Disease
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2025
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| author | Atsushi Hiraoka Hideko Ohama Fujimasa Tada Yuka Kimura Ayaka Nakamura Kazuya Murakawa Takuya Matsuda Kana Matsuoka Kanako Kato Kei Onishi Hirofumi Izumoto Shogo Kitahata Kozue Kanemitsu‐Okada Tomoe Kawamua Taira Kuroda Hideki Miyata Eiji Tsubouchi Osamu Yoshida Masashi Hirooka Masanori Abe Bunzo Matsuura Tomoyuki Ninomiya Sachiyo Yoshio Yoichi Hiasa |
| author_facet | Atsushi Hiraoka Hideko Ohama Fujimasa Tada Yuka Kimura Ayaka Nakamura Kazuya Murakawa Takuya Matsuda Kana Matsuoka Kanako Kato Kei Onishi Hirofumi Izumoto Shogo Kitahata Kozue Kanemitsu‐Okada Tomoe Kawamua Taira Kuroda Hideki Miyata Eiji Tsubouchi Osamu Yoshida Masashi Hirooka Masanori Abe Bunzo Matsuura Tomoyuki Ninomiya Sachiyo Yoshio Yoichi Hiasa Atsushi Hiraoka Hideko Ohama Fujimasa Tada Yuka Kimura Ayaka Nakamura Kazuya Murakawa Takuya Matsuda Kana Matsuoka Kanako Kato Kei Onishi Hirofumi Izumoto Shogo Kitahata Kozue Kanemitsu‐Okada Tomoe Kawamua Taira Kuroda Hideki Miyata Eiji Tsubouchi Osamu Yoshida Masashi Hirooka Masanori Abe Bunzo Matsuura Tomoyuki Ninomiya Sachiyo Yoshio Yoichi Hiasa |
| collection | Wiley Open Access |
| contents | Development of Simplified Risk Assessment Scoring System for Sarcopenia in Patients With Chronic Liver Disease Atsushi Hiraoka Hideko Ohama Fujimasa Tada Yuka Kimura Ayaka Nakamura Kazuya Murakawa Takuya Matsuda Kana Matsuoka Kanako Kato Kei Onishi Hirofumi Izumoto Shogo Kitahata Kozue Kanemitsu‐Okada Tomoe Kawamua Taira Kuroda Hideki Miyata Eiji Tsubouchi Osamu Yoshida Masashi Hirooka Masanori Abe Bunzo Matsuura Tomoyuki Ninomiya Sachiyo Yoshio Yoichi Hiasa Hepatology Research ABSTRACT Background/Aim Secondary sarcopenia is frequently observed in patients with chronic liver disease (CLD), and simple and practical assessment tools in aging society are limited. This study aimed to develop a risk scoring system based on the geriatric nutritional risk index (GNRI) to identify muscle abnormalities in patients with CLD. Materials/Methods Retrospective analysis was carried out on 1181 Japanese patients with CLD (median age 70 years; male:female = 748:433 and Child–Pugh A:B:C = 1029:129:23). LC was noted in 684. Handgrip strength decline (HGSD) and muscle volume loss (MVL) were evaluated using cutoffs established by the Japan Society of Hepatology. Results The proposed scoring system (SDGS‐L) was developed using logistic analysis. Factors included abnormal GNRI (< 98) (odds ratio [OR] 4.69), elderly (65–74 years and OR 2.62), late‐stage elderly (≥ 75 years and OR 6.34), and female gender (OR 2.16), with points assigned based on OR values: 1 point for OR ≦ 3 and 2 points for OR > 3. Sarcopenia/HGSD/MVL prevalence increased with risk scores: 2.3%/13.8%/7.4%, 8.3%/25.8%/19.7%, 21.2%/29.3%/19.2%, and 37.0%/28.6%/18.0% for low (score 0/1), moderate (score 2), high (score 3), and super‐high (score 4/5) scores, respectively ( p < 0.001). GNRI cutoffs for HGS decline and muscle volume loss were 101.5 (AUC 0.675) and 97.7 (AUC 0.742). Significant correlations of GNRI with HGS and skeletal muscle index (SMI) were observed in males ( r = 0.365)/( r = 0.493) and females ( r = 0.297)/( r = 0.462) (each p < 0.001). Conclusion The SDGS‐L scoring system provides a simple cost‐effective tool for predicting sarcopenia and muscle abnormalities in patients with CLD, enabling early intervention without specialized equipment. 10.1111/hepr.70002 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/hepr.70002 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_hepr_70002 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Development of Simplified Risk Assessment Scoring System for Sarcopenia in Patients With Chronic Liver Disease Atsushi Hiraoka Hideko Ohama Fujimasa Tada Yuka Kimura Ayaka Nakamura Kazuya Murakawa Takuya Matsuda Kana Matsuoka Kanako Kato Kei Onishi Hirofumi Izumoto Shogo Kitahata Kozue Kanemitsu‐Okada Tomoe Kawamua Taira Kuroda Hideki Miyata Eiji Tsubouchi Osamu Yoshida Masashi Hirooka Masanori Abe Bunzo Matsuura Tomoyuki Ninomiya Sachiyo Yoshio Yoichi Hiasa Hepatology Research Development of Simplified Risk Assessment Scoring System for Sarcopenia in Patients With Chronic Liver Disease Atsushi Hiraoka Hideko Ohama Fujimasa Tada Yuka Kimura Ayaka Nakamura Kazuya Murakawa Takuya Matsuda Kana Matsuoka Kanako Kato Kei Onishi Hirofumi Izumoto Shogo Kitahata Kozue Kanemitsu‐Okada Tomoe Kawamua Taira Kuroda Hideki Miyata Eiji Tsubouchi Osamu Yoshida Masashi Hirooka Masanori Abe Bunzo Matsuura Tomoyuki Ninomiya Sachiyo Yoshio Yoichi Hiasa Hepatology Research ABSTRACT Background/Aim Secondary sarcopenia is frequently observed in patients with chronic liver disease (CLD), and simple and practical assessment tools in aging society are limited. This study aimed to develop a risk scoring system based on the geriatric nutritional risk index (GNRI) to identify muscle abnormalities in patients with CLD. Materials/Methods Retrospective analysis was carried out on 1181 Japanese patients with CLD (median age 70 years; male:female = 748:433 and Child–Pugh A:B:C = 1029:129:23). LC was noted in 684. Handgrip strength decline (HGSD) and muscle volume loss (MVL) were evaluated using cutoffs established by the Japan Society of Hepatology. Results The proposed scoring system (SDGS‐L) was developed using logistic analysis. Factors included abnormal GNRI (< 98) (odds ratio [OR] 4.69), elderly (65–74 years and OR 2.62), late‐stage elderly (≥ 75 years and OR 6.34), and female gender (OR 2.16), with points assigned based on OR values: 1 point for OR ≦ 3 and 2 points for OR > 3. Sarcopenia/HGSD/MVL prevalence increased with risk scores: 2.3%/13.8%/7.4%, 8.3%/25.8%/19.7%, 21.2%/29.3%/19.2%, and 37.0%/28.6%/18.0% for low (score 0/1), moderate (score 2), high (score 3), and super‐high (score 4/5) scores, respectively ( p < 0.001). GNRI cutoffs for HGS decline and muscle volume loss were 101.5 (AUC 0.675) and 97.7 (AUC 0.742). Significant correlations of GNRI with HGS and skeletal muscle index (SMI) were observed in males ( r = 0.365)/( r = 0.493) and females ( r = 0.297)/( r = 0.462) (each p < 0.001). Conclusion The SDGS‐L scoring system provides a simple cost‐effective tool for predicting sarcopenia and muscle abnormalities in patients with CLD, enabling early intervention without specialized equipment. 10.1111/hepr.70002 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Development of Simplified Risk Assessment Scoring System for Sarcopenia in Patients With Chronic Liver Disease |
| topic | Hepatology Research |
| url | https://onlinelibrary.wiley.com/doi/10.1111/hepr.70002 |