Enregistré dans:
| Auteurs principaux: | , |
|---|---|
| Format: | Artículo Open Access |
| Publié: |
Wiley
2025
|
| Sujets: | |
| Accès en ligne: | https://onlinelibrary.wiley.com/doi/10.1111/hepr.70113 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Table des matières:
- Diagnostic Performance of Serum Autotaxin for Staging Liver Fibrosis: A Comparative Study With Other Noninvasive Liver Fibrosis Tests in Chronic Liver Disease Hideyuki Tamai Jumpei Okamura Hepatology Research ABSTRACT Aim Serum autotaxin (ATX) has emerged as a promising biomarker for liver fibrosis, despite known sex‐related variability. In addition to the conventional enzyme immunoassay (EIA‐ATX), newer methods have been developed: a chemiluminescent enzyme immunoassay (CL‐ATX), which enables rapid measurement with smaller sample volumes, and an enzyme assay (E‐ATX), compatible with routine clinical chemistry analyzers, thereby enhancing accessibility. This study aimed to evaluate the diagnostic performance of ATX in comparison with other noninvasive tests for liver fibrosis. Methods A total of 357 patients with chronic liver disease who underwent liver biopsy and had measurements of serum MAC‐2 binding protein glycosylation isomer (M2BPGi) and shear wave measurement (SWM) were analyzed. ATX levels were measured using stored serum samples with both EIA‐ATX and CL‐ATX. Additionally, in 317 of these patients, ATX was also measured using the E‐ATX method. Results In male patients, the area under the receiver operating characteristic curve (AUROC) values for predicting significant fibrosis (≥ fibrosis Stage 2) were 0.862 for SWM, 0.836 for M2BPGi, 0.814 for the fibrosis‐4 index, 0.758 for platelet count, 0.800 for EIA‐ATX, 0.790 for CL‐ATX, and 0.783 for E‐ATX. In female patients, the corresponding AUROC values were 0.834, 0.828, 0.857, 0.786, 0.805, 0.804, and 0.805, respectively. No significant differences were observed in AUROC values between ATX and other noninvasive liver fibrosis tests, nor among the different ATX measurement methods. Conclusions ATX demonstrated acceptable diagnostic performance for significant fibrosis, comparable to established noninvasive tests. The availability of E‐ATX on routine chemistry analyzers highlights its potential as a practical biomarker for primary care and health checkups. 10.1111/hepr.70113 http://onlinelibrary.wiley.com/termsAndConditions#vor