Factors associated with sex differences in viral non‐suppression in the Swedish InfCareHIV cohort: An observational real‐world study
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| Format: | Artículo Open Access |
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Wiley
2024
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| _version_ | 1867015299149070336 |
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| author | Maria Lindh Johanna Brännström Anton Reepalu Veronica Svedhem Åsa Mellgren |
| author_facet | Maria Lindh Johanna Brännström Anton Reepalu Veronica Svedhem Åsa Mellgren Maria Lindh Johanna Brännström Anton Reepalu Veronica Svedhem Åsa Mellgren |
| collection | Wiley Open Access |
| contents | Factors associated with sex differences in viral non‐suppression in the Swedish InfCareHIV cohort: An observational real‐world study Maria Lindh Johanna Brännström Anton Reepalu Veronica Svedhem Åsa Mellgren HIV Medicine AbstractObjectivesWomen living with HIV are underrepresented in clinical trials assessing outcomes of antiretroviral treatment (ART), justifying the need for observational studies. We investigated differences in viral non‐suppression between women and men in the Swedish InfCareHIV cohort and analysed results in relation to biological and socio‐demographic variables and patient‐reported outcome measures (PROMs).MethodsThe study included people living with HIV (PLWH) aged ≥18 years, who initiated ART at least 6 months prior to inclusion. Data from the InfCareHIV registry 2011–2018 were collected. Associations between variables and HIV RNA ≥50 copies/mL were investigated in uni‐ and multivariable analyses using generalized estimating equations, providing relative risks (RRs) as effect size.ResultsThe study included 38% (n = 2981) women. Women were more likely to have HIV RNA ≥50 copies/mL than were men [RR = 1.20, 95% confidence interval (CI): 1.10–1.31]. After adjusting for origin and route of transmission, sex at birth was no longer associated with viral non‐suppression. PROMs were available in 52.4% of PLWH, and items associated with viral non‐suppression were impaired adherence in women (RR = 2.38, 95% CI: 1.79–3.17) and men (RR 1.84, 95% CI: 1.40–2.42), and experience of side effects in women (RR = 1.49, 95% CI: 1.10–2.02).ConclusionsThis observational study found a 20% higher relative risk of viral non‐suppression in women than in men and the difference was associated with socio‐demographic factors. The associations between PROMs and viral non‐suppression varied between women and men. PROMs are important health outcomes that may identify PLWH in need of support to achieve viral non‐suppression. 10.1111/hiv.13607 http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| doi_str_mv | 10.1111/hiv.13607 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_hiv_13607 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Factors associated with sex differences in viral non‐suppression in the Swedish InfCareHIV cohort: An observational real‐world study Maria Lindh Johanna Brännström Anton Reepalu Veronica Svedhem Åsa Mellgren HIV Medicine Factors associated with sex differences in viral non‐suppression in the Swedish InfCareHIV cohort: An observational real‐world study Maria Lindh Johanna Brännström Anton Reepalu Veronica Svedhem Åsa Mellgren HIV Medicine AbstractObjectivesWomen living with HIV are underrepresented in clinical trials assessing outcomes of antiretroviral treatment (ART), justifying the need for observational studies. We investigated differences in viral non‐suppression between women and men in the Swedish InfCareHIV cohort and analysed results in relation to biological and socio‐demographic variables and patient‐reported outcome measures (PROMs).MethodsThe study included people living with HIV (PLWH) aged ≥18 years, who initiated ART at least 6 months prior to inclusion. Data from the InfCareHIV registry 2011–2018 were collected. Associations between variables and HIV RNA ≥50 copies/mL were investigated in uni‐ and multivariable analyses using generalized estimating equations, providing relative risks (RRs) as effect size.ResultsThe study included 38% (n = 2981) women. Women were more likely to have HIV RNA ≥50 copies/mL than were men [RR = 1.20, 95% confidence interval (CI): 1.10–1.31]. After adjusting for origin and route of transmission, sex at birth was no longer associated with viral non‐suppression. PROMs were available in 52.4% of PLWH, and items associated with viral non‐suppression were impaired adherence in women (RR = 2.38, 95% CI: 1.79–3.17) and men (RR 1.84, 95% CI: 1.40–2.42), and experience of side effects in women (RR = 1.49, 95% CI: 1.10–2.02).ConclusionsThis observational study found a 20% higher relative risk of viral non‐suppression in women than in men and the difference was associated with socio‐demographic factors. The associations between PROMs and viral non‐suppression varied between women and men. PROMs are important health outcomes that may identify PLWH in need of support to achieve viral non‐suppression. 10.1111/hiv.13607 http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| title | Factors associated with sex differences in viral non‐suppression in the Swedish InfCareHIV cohort: An observational real‐world study |
| topic | HIV Medicine |
| url | https://onlinelibrary.wiley.com/doi/10.1111/hiv.13607 |