Impact of Hyperuricemia on Incident Hypertension When Hypertension Definition Changes From 140/90 to 130/80 mmHg in a Large Taiwanese Population Follow‐Up Study
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2025
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| author | Yi‐Hsueh Liu Wei‐Yu Su Chih‐Yi Lin Chun‐Chi Tsai Ho‐Ming Su Szu‐Chia Chen |
| author_facet | Yi‐Hsueh Liu Wei‐Yu Su Chih‐Yi Lin Chun‐Chi Tsai Ho‐Ming Su Szu‐Chia Chen Yi‐Hsueh Liu Wei‐Yu Su Chih‐Yi Lin Chun‐Chi Tsai Ho‐Ming Su Szu‐Chia Chen |
| collection | Wiley Open Access |
| contents | Impact of Hyperuricemia on Incident Hypertension When Hypertension Definition Changes From 140/90 to 130/80 mmHg in a Large Taiwanese Population Follow‐Up Study Yi‐Hsueh Liu Wei‐Yu Su Chih‐Yi Lin Chun‐Chi Tsai Ho‐Ming Su Szu‐Chia Chen The Journal of Clinical Hypertension ABSTRACTA lower blood pressure threshold (≥130/80 mmHg) to define hypertension has been proposed in several hypertension guidelines. This study assessed the relationship between hyperuricemia and incident hypertension, examining serum uric acid (SUA) cut‐offs using both traditional and new definitions in a large Taiwanese cohort. This observational cohort study enrolled 26 973 participants from the Taiwan Biobank (TWB), followed for a median of 4 years. Regarding traditional definition (140/90 mmHg), hyperuricemia (odds ratio [OR], 1.297), quartile 3 of SUA (OR, 1.211), quartile 4 of SUA (OR, 1.495), and high SUA (OR, 1.127) were significantly associated with incident hypertension in males, and hyperuricemia (OR, 1.198), quartile 4 of SUA (OR, 1.359), and high SUA (OR, 1.099) were significantly associated with incident hypertension in females. As for new definition (130/80 mmHg), hyperuricemia (OR, 1.376), quartile 3 of SUA (OR, 1.229), quartile 4 of SUA (OR, 1.554), and high SUA (OR, 1.139) were associated with incident hypertension in males, and hyperuricemia (OR, 1.249), quartile 3 of SUA (OR, 1.253), quartile 4 of SUA (OR, 1.429), and high SUA (OR, 1.096) were associated with incident hypertension in females. The interaction between hyperuricemia and sex on incident hypertension was significant for both traditional (140/90, p < 0.001) and new (130/80, p = 0.001) definitions. Hyperuricemia was significantly associated with incident hypertension under both traditional and new definitions. A significant interaction between hyperuricemia and sex was noted, although the differences were not so great. 10.1111/jch.70013 http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| doi_str_mv | 10.1111/jch.70013 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_jch_70013 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| publishDate | 2025 |
| publisher | Wiley |
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| spellingShingle | Impact of Hyperuricemia on Incident Hypertension When Hypertension Definition Changes From 140/90 to 130/80 mmHg in a Large Taiwanese Population Follow‐Up Study Yi‐Hsueh Liu Wei‐Yu Su Chih‐Yi Lin Chun‐Chi Tsai Ho‐Ming Su Szu‐Chia Chen The Journal of Clinical Hypertension Impact of Hyperuricemia on Incident Hypertension When Hypertension Definition Changes From 140/90 to 130/80 mmHg in a Large Taiwanese Population Follow‐Up Study Yi‐Hsueh Liu Wei‐Yu Su Chih‐Yi Lin Chun‐Chi Tsai Ho‐Ming Su Szu‐Chia Chen The Journal of Clinical Hypertension ABSTRACTA lower blood pressure threshold (≥130/80 mmHg) to define hypertension has been proposed in several hypertension guidelines. This study assessed the relationship between hyperuricemia and incident hypertension, examining serum uric acid (SUA) cut‐offs using both traditional and new definitions in a large Taiwanese cohort. This observational cohort study enrolled 26 973 participants from the Taiwan Biobank (TWB), followed for a median of 4 years. Regarding traditional definition (140/90 mmHg), hyperuricemia (odds ratio [OR], 1.297), quartile 3 of SUA (OR, 1.211), quartile 4 of SUA (OR, 1.495), and high SUA (OR, 1.127) were significantly associated with incident hypertension in males, and hyperuricemia (OR, 1.198), quartile 4 of SUA (OR, 1.359), and high SUA (OR, 1.099) were significantly associated with incident hypertension in females. As for new definition (130/80 mmHg), hyperuricemia (OR, 1.376), quartile 3 of SUA (OR, 1.229), quartile 4 of SUA (OR, 1.554), and high SUA (OR, 1.139) were associated with incident hypertension in males, and hyperuricemia (OR, 1.249), quartile 3 of SUA (OR, 1.253), quartile 4 of SUA (OR, 1.429), and high SUA (OR, 1.096) were associated with incident hypertension in females. The interaction between hyperuricemia and sex on incident hypertension was significant for both traditional (140/90, p < 0.001) and new (130/80, p = 0.001) definitions. Hyperuricemia was significantly associated with incident hypertension under both traditional and new definitions. A significant interaction between hyperuricemia and sex was noted, although the differences were not so great. 10.1111/jch.70013 http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| title | Impact of Hyperuricemia on Incident Hypertension When Hypertension Definition Changes From 140/90 to 130/80 mmHg in a Large Taiwanese Population Follow‐Up Study |
| topic | The Journal of Clinical Hypertension |
| url | https://onlinelibrary.wiley.com/doi/10.1111/jch.70013 |