Mapping associations of polygenic scores with autistic and ADHD traits in a single city region
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| Format: | Artículo Open Access |
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Wiley
2024
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| author | Zoe E. Reed Richard Thomas Andy Boyd Gareth J. Griffith Tim T. Morris Dheeraj Rai David Manley George Davey Smith Oliver S.P. Davis |
| author_facet | Zoe E. Reed Richard Thomas Andy Boyd Gareth J. Griffith Tim T. Morris Dheeraj Rai David Manley George Davey Smith Oliver S.P. Davis Zoe E. Reed Richard Thomas Andy Boyd Gareth J. Griffith Tim T. Morris Dheeraj Rai David Manley George Davey Smith Oliver S.P. Davis |
| collection | Wiley Open Access |
| contents | Mapping associations of polygenic scores with autistic and ADHD traits in a single city region Zoe E. Reed Richard Thomas Andy Boyd Gareth J. Griffith Tim T. Morris Dheeraj Rai David Manley George Davey Smith Oliver S.P. Davis Journal of Child Psychology and Psychiatry Background The genetic and environmental aetiology of autistic and Attention Deficit Hyperactivity Disorder (ADHD) traits is known to vary spatially, but does this translate into variation in the association of specific common genetic variants? Methods We mapped associations between polygenic scores for autism and ADHD and their respective traits in the Avon Longitudinal Study of Parents and Children ( N = 4,255–6,165) across the area surrounding Bristol, UK, and compared them to maps of environments associated with the prevalence of autism and ADHD. Results Our results suggest genetic associations vary spatially, with consistent patterns for autistic traits across polygenic scores constructed at different p ‐value thresholds. Patterns for ADHD traits were more variable across thresholds. We found that the spatial distributions often correlated with known environmental influences. Conclusions These findings shed light on the factors that contribute to the complex interplay between the environment and genetic influences in autistic and ADHD traits. 10.1111/jcpp.14047 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1111/jcpp.14047 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_jcpp_14047 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Mapping associations of polygenic scores with autistic and ADHD traits in a single city region Zoe E. Reed Richard Thomas Andy Boyd Gareth J. Griffith Tim T. Morris Dheeraj Rai David Manley George Davey Smith Oliver S.P. Davis Journal of Child Psychology and Psychiatry Mapping associations of polygenic scores with autistic and ADHD traits in a single city region Zoe E. Reed Richard Thomas Andy Boyd Gareth J. Griffith Tim T. Morris Dheeraj Rai David Manley George Davey Smith Oliver S.P. Davis Journal of Child Psychology and Psychiatry Background The genetic and environmental aetiology of autistic and Attention Deficit Hyperactivity Disorder (ADHD) traits is known to vary spatially, but does this translate into variation in the association of specific common genetic variants? Methods We mapped associations between polygenic scores for autism and ADHD and their respective traits in the Avon Longitudinal Study of Parents and Children ( N = 4,255–6,165) across the area surrounding Bristol, UK, and compared them to maps of environments associated with the prevalence of autism and ADHD. Results Our results suggest genetic associations vary spatially, with consistent patterns for autistic traits across polygenic scores constructed at different p ‐value thresholds. Patterns for ADHD traits were more variable across thresholds. We found that the spatial distributions often correlated with known environmental influences. Conclusions These findings shed light on the factors that contribute to the complex interplay between the environment and genetic influences in autistic and ADHD traits. 10.1111/jcpp.14047 http://creativecommons.org/licenses/by/4.0/ |
| title | Mapping associations of polygenic scores with autistic and ADHD traits in a single city region |
| topic | Journal of Child Psychology and Psychiatry |
| url | https://acamh.onlinelibrary.wiley.com/doi/10.1111/jcpp.14047 |