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| Format: | Artículo Open Access |
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Wiley
2025
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| Accès en ligne: | https://acamh.onlinelibrary.wiley.com/doi/10.1111/jcpp.14180 |
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| _version_ | 1867020813798998016 |
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| author | Frances S. Chen Bita Zareian Marisa A. Nelson Nina Edwards Christine Anderl |
| author_facet | Frances S. Chen Bita Zareian Marisa A. Nelson Nina Edwards Christine Anderl Frances S. Chen Bita Zareian Marisa A. Nelson Nina Edwards Christine Anderl |
| collection | Wiley Open Access |
| contents | Research Review: Are sampling biases masking long‐term effects of hormonal contraceptive use in adolescence on risk for depression? Frances S. Chen Bita Zareian Marisa A. Nelson Nina Edwards Christine Anderl Journal of Child Psychology and Psychiatry Background Growing evidence suggests that the use of hormonal contraceptives (HCs) during adolescence may be linked to an increased risk for depression. This review examines major inconsistencies that have been reported regarding this relationship, and in particular, how the common practice of combining ‘never users’ and ‘former users’ of HCs in analyses obscures patterns that are detectable when these groups are analyzed separately. Methods A review was conducted of research examining the relationship between HC use and depression to determine what data‐analytic choices were commonly made by individual researchers. Specifically, we assessed whether the past history of HC use had been accounted for in each reported analysis. Results The majority of papers published between 2013 and 2022 did not account for the former use of HCs. These papers reported mixed findings regarding the relationship between HC use and depression. In contrast, the subset of papers that did account for former use of HCs, or otherwise explicitly addressed common biases affecting the interpretation of observational data, revealed a more consistent relationship between HC use and depression, particularly for those who began using HCs during adolescence. Conclusion We conclude that there is consistent evidence of a relationship between adolescent HC use and long‐term risk for depression and offer several recommendations to help ensure that future work in this area will yield consistent, interpretable findings. Although this paper focuses primarily on HCs and depression, many of the analytical approaches and recommendations outlined within it are also relevant to research on the side effects of other drugs and medications. 10.1111/jcpp.14180 http://creativecommons.org/licenses/by-nc/4.0/ |
| doi_str_mv | 10.1111/jcpp.14180 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_jcpp_14180 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by-nc/4.0/ |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Research Review: Are sampling biases masking long‐term effects of hormonal contraceptive use in adolescence on risk for depression? Frances S. Chen Bita Zareian Marisa A. Nelson Nina Edwards Christine Anderl Journal of Child Psychology and Psychiatry Research Review: Are sampling biases masking long‐term effects of hormonal contraceptive use in adolescence on risk for depression? Frances S. Chen Bita Zareian Marisa A. Nelson Nina Edwards Christine Anderl Journal of Child Psychology and Psychiatry Background Growing evidence suggests that the use of hormonal contraceptives (HCs) during adolescence may be linked to an increased risk for depression. This review examines major inconsistencies that have been reported regarding this relationship, and in particular, how the common practice of combining ‘never users’ and ‘former users’ of HCs in analyses obscures patterns that are detectable when these groups are analyzed separately. Methods A review was conducted of research examining the relationship between HC use and depression to determine what data‐analytic choices were commonly made by individual researchers. Specifically, we assessed whether the past history of HC use had been accounted for in each reported analysis. Results The majority of papers published between 2013 and 2022 did not account for the former use of HCs. These papers reported mixed findings regarding the relationship between HC use and depression. In contrast, the subset of papers that did account for former use of HCs, or otherwise explicitly addressed common biases affecting the interpretation of observational data, revealed a more consistent relationship between HC use and depression, particularly for those who began using HCs during adolescence. Conclusion We conclude that there is consistent evidence of a relationship between adolescent HC use and long‐term risk for depression and offer several recommendations to help ensure that future work in this area will yield consistent, interpretable findings. Although this paper focuses primarily on HCs and depression, many of the analytical approaches and recommendations outlined within it are also relevant to research on the side effects of other drugs and medications. 10.1111/jcpp.14180 http://creativecommons.org/licenses/by-nc/4.0/ |
| title | Research Review: Are sampling biases masking long‐term effects of hormonal contraceptive use in adolescence on risk for depression? |
| topic | Journal of Child Psychology and Psychiatry |
| url | https://acamh.onlinelibrary.wiley.com/doi/10.1111/jcpp.14180 |