The role of comorbid childhood mental health and neurodevelopmental conditions in the persistence of ADHD symptoms: systematic review and meta‐analysis
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2025
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| author | Yuan You Tom McAdams Yasmin I. Ahmadzadeh Tabea Schoeler Filip Marzecki Helena M.S. Zavos |
| author_facet | Yuan You Tom McAdams Yasmin I. Ahmadzadeh Tabea Schoeler Filip Marzecki Helena M.S. Zavos Yuan You Tom McAdams Yasmin I. Ahmadzadeh Tabea Schoeler Filip Marzecki Helena M.S. Zavos |
| collection | Wiley Open Access |
| contents | The role of comorbid childhood mental health and neurodevelopmental conditions in the persistence of ADHD symptoms: systematic review and meta‐analysis Yuan You Tom McAdams Yasmin I. Ahmadzadeh Tabea Schoeler Filip Marzecki Helena M.S. Zavos Journal of Child Psychology and Psychiatry Background Children diagnosed with ADHD and other comorbid mental health conditions often exhibit more severe functional impairments than those without comorbid conditions, including a tendency for their ADHD symptoms to persist into later developmental stages. We conducted a systematic review and quantitative analysis to investigate the extent to which specific childhood comorbidities (internalizing, externalizing and neurodevelopmental conditions) predict the persistence of childhood ADHD into later developmental stages. Methods We extracted data from 26 studies meeting the criteria for inclusion and applied multilevel random effects models to obtain pooled estimates of Cohen's d for selected predictors on ADHD persistence. Results Childhood comorbid internalizing and externalizing conditions ( d = 0.19 and d = 0.31, respectively), but not neurodevelopmental disorders, were significantly associated with ADHD persistence. After adjusting for covariates (sex, age and other comorbidities), this association diminished for externalizing conditions ( d adj = 0.24) and was no longer significant for internalizing conditions ( d adj = 0.06). The association between comorbid externalizing behavior problems and ADHD persistence was found only in studies that used parent‐reported data to measure childhood ADHD and externalizing conditions, but not in studies that included teacher‐reported childhood symptoms. Conclusions Childhood comorbid externalizing and, to a lesser extent, internalizing conditions were associated with the persistence of ADHD, but this association may be partially due to confounders. Childhood comorbidity of neurodevelopmental disorders does not appear to increase the likelihood of ADHD persistence. 10.1111/jcpp.70028 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1111/jcpp.70028 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_jcpp_70028 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | The role of comorbid childhood mental health and neurodevelopmental conditions in the persistence of ADHD symptoms: systematic review and meta‐analysis Yuan You Tom McAdams Yasmin I. Ahmadzadeh Tabea Schoeler Filip Marzecki Helena M.S. Zavos Journal of Child Psychology and Psychiatry The role of comorbid childhood mental health and neurodevelopmental conditions in the persistence of ADHD symptoms: systematic review and meta‐analysis Yuan You Tom McAdams Yasmin I. Ahmadzadeh Tabea Schoeler Filip Marzecki Helena M.S. Zavos Journal of Child Psychology and Psychiatry Background Children diagnosed with ADHD and other comorbid mental health conditions often exhibit more severe functional impairments than those without comorbid conditions, including a tendency for their ADHD symptoms to persist into later developmental stages. We conducted a systematic review and quantitative analysis to investigate the extent to which specific childhood comorbidities (internalizing, externalizing and neurodevelopmental conditions) predict the persistence of childhood ADHD into later developmental stages. Methods We extracted data from 26 studies meeting the criteria for inclusion and applied multilevel random effects models to obtain pooled estimates of Cohen's d for selected predictors on ADHD persistence. Results Childhood comorbid internalizing and externalizing conditions ( d = 0.19 and d = 0.31, respectively), but not neurodevelopmental disorders, were significantly associated with ADHD persistence. After adjusting for covariates (sex, age and other comorbidities), this association diminished for externalizing conditions ( d adj = 0.24) and was no longer significant for internalizing conditions ( d adj = 0.06). The association between comorbid externalizing behavior problems and ADHD persistence was found only in studies that used parent‐reported data to measure childhood ADHD and externalizing conditions, but not in studies that included teacher‐reported childhood symptoms. Conclusions Childhood comorbid externalizing and, to a lesser extent, internalizing conditions were associated with the persistence of ADHD, but this association may be partially due to confounders. Childhood comorbidity of neurodevelopmental disorders does not appear to increase the likelihood of ADHD persistence. 10.1111/jcpp.70028 http://creativecommons.org/licenses/by/4.0/ |
| title | The role of comorbid childhood mental health and neurodevelopmental conditions in the persistence of ADHD symptoms: systematic review and meta‐analysis |
| topic | Journal of Child Psychology and Psychiatry |
| url | https://acamh.onlinelibrary.wiley.com/doi/10.1111/jcpp.70028 |