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| Format: | Artículo Open Access |
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Wiley
2025
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| Online Access: | https://acamh.onlinelibrary.wiley.com/doi/10.1111/jcpp.70060 |
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| author | Jonathan Posner Andrew Michael Pratik Kashyap Meredith Fay Ana Carolina Coelho Milani Ivaldo Silva Nitamar Abdala Célia Maria de Araújo Aline Camargo Ramos Yun Wang Mateus Mazzaferro Andrea Jackowski Cristiane S. Duarte |
| author_facet | Jonathan Posner Andrew Michael Pratik Kashyap Meredith Fay Ana Carolina Coelho Milani Ivaldo Silva Nitamar Abdala Célia Maria de Araújo Aline Camargo Ramos Yun Wang Mateus Mazzaferro Andrea Jackowski Cristiane S. Duarte Jonathan Posner Andrew Michael Pratik Kashyap Meredith Fay Ana Carolina Coelho Milani Ivaldo Silva Nitamar Abdala Célia Maria de Araújo Aline Camargo Ramos Yun Wang Mateus Mazzaferro Andrea Jackowski Cristiane S. Duarte |
| collection | Wiley Open Access |
| contents | Perinatal hardship and infant neurodevelopment: insights from a global pandemic Jonathan Posner Andrew Michael Pratik Kashyap Meredith Fay Ana Carolina Coelho Milani Ivaldo Silva Nitamar Abdala Célia Maria de Araújo Aline Camargo Ramos Yun Wang Mateus Mazzaferro Andrea Jackowski Cristiane S. Duarte Journal of Child Psychology and Psychiatry Background Material and emotional hardship during pregnancy can shape early brain development and behavior in infants. This study used the COVID‐19 pandemic as a natural context in which such hardships were widespread, particularly in low‐resource settings. Methods This cohort study examined associations between pandemic‐related maternal emotional distress and material hardship during pregnancy and early neurodevelopmental outcomes in infants. A total of 235 mother–infant dyads from low‐resource healthcare settings in Brazil were enrolled during the COVID‐19 pandemic. Maternal hardships were assessed using a COVID‐19‐specific questionnaire, which included self‐reported COVID‐19 exposure/infection. Infant neurodevelopment was evaluated via MRI at 2–6 weeks of age and behavioral assessments at 14 months using the Bayley Scales of Infant Development. Results Material hardship was associated with reduced hippocampal volumes in the left ( p fdr = .008) and right ( p fdr = .025) hemispheres. Among female infants, material hardship was linked to lower functional connectivity between the right hippocampus and the right rostral anterior cingulate cortex ( p = .004). Smaller hippocampal volumes correlated with weaker gross motor skills at 14 months ( r = .23; p = .02). Maternal emotional distress and self‐reported COVID‐19 exposure/infection were not significantly associated with infant neurodevelopmental outcomes. Conclusions Material hardship may adversely affect early neurodevelopment, particularly hippocampal structure and connectivity, with potential downstream effects on motor skills. These findings underscore the importance of addressing material hardship during the perinatal period to support infant brain health and development. 10.1111/jcpp.70060 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/jcpp.70060 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_jcpp_70060 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Perinatal hardship and infant neurodevelopment: insights from a global pandemic Jonathan Posner Andrew Michael Pratik Kashyap Meredith Fay Ana Carolina Coelho Milani Ivaldo Silva Nitamar Abdala Célia Maria de Araújo Aline Camargo Ramos Yun Wang Mateus Mazzaferro Andrea Jackowski Cristiane S. Duarte Journal of Child Psychology and Psychiatry Perinatal hardship and infant neurodevelopment: insights from a global pandemic Jonathan Posner Andrew Michael Pratik Kashyap Meredith Fay Ana Carolina Coelho Milani Ivaldo Silva Nitamar Abdala Célia Maria de Araújo Aline Camargo Ramos Yun Wang Mateus Mazzaferro Andrea Jackowski Cristiane S. Duarte Journal of Child Psychology and Psychiatry Background Material and emotional hardship during pregnancy can shape early brain development and behavior in infants. This study used the COVID‐19 pandemic as a natural context in which such hardships were widespread, particularly in low‐resource settings. Methods This cohort study examined associations between pandemic‐related maternal emotional distress and material hardship during pregnancy and early neurodevelopmental outcomes in infants. A total of 235 mother–infant dyads from low‐resource healthcare settings in Brazil were enrolled during the COVID‐19 pandemic. Maternal hardships were assessed using a COVID‐19‐specific questionnaire, which included self‐reported COVID‐19 exposure/infection. Infant neurodevelopment was evaluated via MRI at 2–6 weeks of age and behavioral assessments at 14 months using the Bayley Scales of Infant Development. Results Material hardship was associated with reduced hippocampal volumes in the left ( p fdr = .008) and right ( p fdr = .025) hemispheres. Among female infants, material hardship was linked to lower functional connectivity between the right hippocampus and the right rostral anterior cingulate cortex ( p = .004). Smaller hippocampal volumes correlated with weaker gross motor skills at 14 months ( r = .23; p = .02). Maternal emotional distress and self‐reported COVID‐19 exposure/infection were not significantly associated with infant neurodevelopmental outcomes. Conclusions Material hardship may adversely affect early neurodevelopment, particularly hippocampal structure and connectivity, with potential downstream effects on motor skills. These findings underscore the importance of addressing material hardship during the perinatal period to support infant brain health and development. 10.1111/jcpp.70060 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Perinatal hardship and infant neurodevelopment: insights from a global pandemic |
| topic | Journal of Child Psychology and Psychiatry |
| url | https://acamh.onlinelibrary.wiley.com/doi/10.1111/jcpp.70060 |