Imagen de Portada

A Computational Approach to Identify Novel Protein Targets Uncovers New Potential Mechanisms of Action of Mirtazapine S (+) and R (−) Enantiomers in Rett Syndrome

Fuente: Wiley Open Access

Guardado en:

Detalles Bibliográficos
Autores principales:	Ottavia Maria Roggero, Nicolò Gualandi, Viviana Ciraci, Vittoria Berutto, Emanuele Carosati, Enrico Tongiorgi
Formato:	Artículo Open Access
Publicado:	Wiley 2025
Materias:	Journal of Neurochemistry
Acceso en línea:	Acceder al recurso
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

Prion Protein Endoproteolysis: Cleavage Sites, Mechanisms and Connections to Prion Disease
por: Andrew R. Castle, et al.
Publicado: (2025)

Cocaine‐Induced Changes in the BRD 4 Interactome Identifies Casein Kinase 1 Epsilon as a Therapeutic Target
por: Afshin Seyednejad, et al.
Publicado: (2026)

Discovery and Characterization of Novel Spirotriazoloquinazolines as Potential Neuroprotectors: Synthesis, Computational Screening, and Preliminary In Vivo Evaluation
por: Kostiantyn Shabelnyk, et al.
Publicado: (2026)

S100a9 Aggravates Ischemia Brain Injury via Pyroptosis Pathway: A Potential Prognostic Biomarker and Therapeutic Target for Ischemic Stroke
por: Wenchao Fu, et al.
Publicado: (2025)

Uncovering Hidden Phenotypes in NEX ‐Cre Mice: Behavioral and Cellular Alterations Demand Re‐Evaluation of a Widely Used Transgenic Line
por: Kim Renken, et al.
Publicado: (2026)

Local Protein Synthesis at Synapses: A Driver for Synapse Diversification
por: Ezgi Daskin, et al.
Publicado: (2025)

G Protein‐Coupled Receptor Signaling in CNS (Re)Myelination
por: Jack K. McDonald, et al.
Publicado: (2025)

Tubulin‐Binding Region Modulates Cholesterol‐Triggered Aggregation of Tau Proteins
por: Abid Ali, et al.
Publicado: (2025)

SOD1 Protein Content in Human Central Nervous System and Peripheral Tissues
por: Laura Leykam, et al.
Publicado: (2025)

CacyBP/SIP Protein Regulates the Length and Branching of Neuronal Processes During Cortical Development
por: Katarzyna Bartkowska, et al.
Publicado: (2025)

TREM2 and Pain Development: An Old Molecule, a New Target
por: Zhenzhen Fan, et al.
Publicado: (2025)

Brain Transcriptome Changes Associated With an Acute Increase of Protein O‐ GlcNAcylation and Implications for Neurodegenerative Disease
por: Margaret B. Bell, et al.
Publicado: (2025)

Dissociation of the mTOR Protein Interaction Network Following Neuronal Activation Is Altered by Shank3 Mutation
por: Devin T. Wehle, et al.
Publicado: (2026)

14‐3‐3 Proteins Negatively Regulate Microglial Activation via Inhibition of the NF‐κB Pathway
por: William J. Stone, et al.
Publicado: (2025)

Correction to “Dissociation of the mTOR Protein Interaction Network Following Neuronal Activation Is Altered by Shank3 Mutation”
Publicado: (2026)

Reelin Increases the Sphingomyelin Content of the Plasma Membrane and Affects the Surface Expression of GPI ‐Anchored Proteins in Hippocampal Neurons
por: Yuto Takekoshi, et al.
Publicado: (2025)

Writing the Engram: Epigenetic Mechanisms of Memory Allocation
por: Isabella Tarulli, et al.
Publicado: (2025)

Phase Separation and Prion‐Like Aggregation of p53 Family Tumor Suppressors: From Protein Evolution to Cancer Treatment
por: Jerson L. Silva, et al.
Publicado: (2025)

Correction to “Inhalation of Hydrogen Gas Mitigates Sevoflurane‐Induced Neuronal Apoptosis in the Neonatal Cortex and is Associated With Changes in Protein Phosphorylation”
Publicado: (2025)

Indole and Coumarin Derivatives Targeting EEF2K in Aβ Folding Reporter Cells
por: Shun‐Tzu Chi, et al.
Publicado: (2025)

TRPV4 Channel Participates in the Nociception and Spinal Neuroinflammation Involved in a Model of Complex Regional Pain Syndrome Type I ( CPIP ) in Mice
por: Náthaly Andrighetto Ruviaro, et al.
Publicado: (2025)

Prenatal Alcohol Consumption Alters Protein Fingerprint in Umbilical Cord Blood Serum and Induces Brain Microvascular Endothelial Cell Dysfunction
por: Paula Silva Lacerda Almeida, et al.
Publicado: (2025)

Modulating the cholinergic system—Novel targets for deep brain stimulation in Parkinson's disease
por: V. Witzig, et al.
Publicado: (2024)

Calcium‐Dependent Signaling in Astrocytes: Downstream Mechanisms and Implications for Cognition
por: Alexandra Veiga, et al.
Publicado: (2025)

cAMP ‐Response Element ( CRE )‐Mediated Transcription by CRE ‐Binding Protein ( CREB ) Is Essential for Human Tryptophan Hydroxylase 2 Gene Expression
por: Yukino Nawa, et al.
Publicado: (2025)

Neural Stem Cells in Demyelinating Diseases: Interplay Between Lineage Potential and the Microenvironmental Constraints in Remyelination
por: Agustin Jesus Byrne, et al.
Publicado: (2026)

Glia‐to‐Axon Transfer of Ribosomes and miRNAs : A Novel Paradigm in Neural Repair
por: Francisca Marín‐Venegas, et al.
Publicado: (2026)

Correction to “Targeting Glutamate Excitotoxicity with Memantine Modulates Glial Response and Protects Motoneurons After Spinal Root Lesion”
Publicado: (2026)

Organelle phenotyping and multi‐dimensional microscopy identify C1q as a novel regulator of microglial function
por: Pooja S. Sakthivel, et al.
Publicado: (2024)

Age‐Progressive Synaptic and Axonal Dysregulation Induced by Purkinje Cell–Targeted AAV Expression of SCA14 PKCγ in Mice
por: Naoko Adachi, et al.
Publicado: (2025)

PPARβ/δ Activation Improves Corticosterone‐Induced Oxidative Stress Damage in Astrocytes by Targeting UBR5/ATM Signaling
por: Juan Ji, et al.
Publicado: (2025)

Mechanisms of synapse‐to‐nucleus calcium signalling in striatal neurons and impairments in Huntington's disease
por: Wissam B. Nassrallah, et al.
Publicado: (2024)

Astrocytic Interleukin‐33 Deficiency Reduces Glial Fibrillary Acidic Protein Expression and Exacerbates Microglial Activation and Neuronal Damage in a Chemically Induced Inflamed Frontal Cortex
por: Yu‐Chen Zheng, et al.
Publicado: (2025)

Crosstalk Between Astrocytes and Inhibitory Neurons During Maturation: Emerging Mechanisms and Functional Implications
por: Niina Lehti Tauriala, et al.
Publicado: (2025)

Unveiling the Therapeutic Potential of D2AAK1 and Its Derivatives: Mechanistic Insights and Applications in Neurodegenerative Disease Treatment
por: Michał K. Jastrzębski, et al.
Publicado: (2025)

Prenatal Exposure to Lipopolysaccharide or Valproate Leads to Abnormal Accumulation of the NMDA Receptor Agonist D‐Aspartate in the Adolescent Rat Brain
por: Anna Di Maio, et al.
Publicado: (2025)

Control of Synaptotagmin‐1 Trafficking by SV2A —Mechanism and Consequences for Presynaptic Function and Dysfunction
por: James A. Hogg, et al.
Publicado: (2025)

Serum Proteome Profiling Implicates Dysregulation of Immune Response and Inflammatory Mechanisms in Methylmalonic Acidemia With Brain Injury
por: Yumei Su, et al.
Publicado: (2025)

Regulatory Dynamics of Nrf2 With Sirtuins in the Brain: Exploring Cellular Metabolism, Synaptic Plasticity, and Defense Mechanisms
por: Efrain J. Perez Lao, et al.
Publicado: (2025)

Astrocyte Bioenergetic Remodeling as a Central Trait of Disrupted Glucocorticoid Signaling: Mechanisms and Implications for Stress Vulnerability
por: Paweł Hanus, et al.
Publicado: (2026)