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| Main Authors: | , , , , , , , , |
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| Format: | Artículo Open Access |
| Published: |
Wiley
2025
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| Online Access: | https://onlinelibrary.wiley.com/doi/10.1111/jon.70039 |
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- Brain Volume Loss After Stereotactic Laser Interstitial Thermal Therapy in Patients With Temporal Lobe Epilepsy Sebastian Johannes Müller Eya Khadhraoui Olga Kukhlenko Johannes Schwarzer Jürgen Voges I. Erol Sandalcioglu Daniel Behme Friedhelm Schmitt Lars Büntjen Journal of Neuroimaging ABSTRACTBackground and PurposeTemporal lobe epilepsy is the most common form of focal epilepsy. MR‐guided laser interstitial thermal therapy (LITT) of the amygdalohippocampal complex has become an established therapy option in case of drug resistance. Long‐term anatomic network effects on the brain due to deafferentiation have not yet been evaluated.MethodsWe analyzed brain volumes of 11 patients with temporal lobe epilepsy before and 1‐year after hippocampal LITT with FastSurfer segmenting T1‐weighted data. Additionally, we performed visual ratings and measurements.ResultsA total of 11 patients with temporal lobe epilepsy (7 left‐sided, 4 right‐sided) were included (5 females); the mean age years (±standard deviation) at surgery was 41.5 (±18.4) years. The mean postoperative defect size was 1427 (±517) mm3. Volumetry as well as visual ratings found a progressive volume loss after left‐sided surgery in the ipsilateral temporal lobe, the contralateral (right) part of the thalamus, and especially contralateral (right) fusiform cortex. These changes could not be detected for right‐sided surgery.ConclusionA (partial) ablation of the left (dominant) hippocampus appears to exert long‐term effects on the right thalamus and right‐sided temporal cortices. However, we could not observe this effect in the reverse direction. Volumetric studies for larger cohorts should be conducted to investigate these findings. 10.1111/jon.70039 http://creativecommons.org/licenses/by/4.0/