Corticospinal Tract Injury Leads to Poor Motor Recovery Immediately After Ischemic Stroke
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2025
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| author | Muhib Khan Leo Gallagher Laurel Packard Jessica Parker Dave Chesla Gabe Heredia |
| author_facet | Muhib Khan Leo Gallagher Laurel Packard Jessica Parker Dave Chesla Gabe Heredia Muhib Khan Leo Gallagher Laurel Packard Jessica Parker Dave Chesla Gabe Heredia |
| collection | Wiley Open Access |
| contents | Corticospinal Tract Injury Leads to Poor Motor Recovery Immediately After Ischemic Stroke Muhib Khan Leo Gallagher Laurel Packard Jessica Parker Dave Chesla Gabe Heredia Journal of Neuroimaging ABSTRACT Background and Purpose Corticospinal tract (CST) integrity is an imaging biomarker for predicting upper extremity motor recovery, but data are limited in acute ischemic stroke patients. Our study aimed to assess the impact of CST disruption on upper extremity motor recovery after acute ischemic stroke. Methods We enrolled patients with upper extremity motor deficits within 7 days of stroke onset. Patients’ clinical status was assessed for the upper extremity Fugl–Meyer assessment motor component (UE‐FM) within 7 days of stroke and at 15, 30, and 90 days. MRI with tractography was performed within 7 days of stroke. Diffusion tensor images (DTI) were processed to produce maps of fractional anisotropy (FA), apparent diffusion, axial, radial, and mean diffusivity. FA maps were used to assess CST asymmetry index (CST‐AI). Fisher's exact tests for categorical variables, two‐sample t ‐tests for normally distributed numerical data, and Wilcoxon rank sums for non‐normally distributed numeric data were used. Results A total of 21 patients were enrolled in the study with a mean age of 66 (±14) years and median baseline upper extremity motor component score (UE‐FM) of 42 (median) [range: 23, 53]. Baseline UE‐FM was not predictive of a 10‐point change at 90 days ( p = 0.4469). CST‐AI was predictive of recovery at 15 days ( p = 0.0373), and axial diffusivity was predictive of recovery at 90 days ( p = 0.0402). All other imaging variables did not predict recovery. Conclusion Our data suggest that upper extremity motor recovery after acute ischemic stroke is impacted by CST integrity. Further studies are needed to validate our findings. 10.1111/jon.70095 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/jon.70095 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_jon_70095 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Corticospinal Tract Injury Leads to Poor Motor Recovery Immediately After Ischemic Stroke Muhib Khan Leo Gallagher Laurel Packard Jessica Parker Dave Chesla Gabe Heredia Journal of Neuroimaging Corticospinal Tract Injury Leads to Poor Motor Recovery Immediately After Ischemic Stroke Muhib Khan Leo Gallagher Laurel Packard Jessica Parker Dave Chesla Gabe Heredia Journal of Neuroimaging ABSTRACT Background and Purpose Corticospinal tract (CST) integrity is an imaging biomarker for predicting upper extremity motor recovery, but data are limited in acute ischemic stroke patients. Our study aimed to assess the impact of CST disruption on upper extremity motor recovery after acute ischemic stroke. Methods We enrolled patients with upper extremity motor deficits within 7 days of stroke onset. Patients’ clinical status was assessed for the upper extremity Fugl–Meyer assessment motor component (UE‐FM) within 7 days of stroke and at 15, 30, and 90 days. MRI with tractography was performed within 7 days of stroke. Diffusion tensor images (DTI) were processed to produce maps of fractional anisotropy (FA), apparent diffusion, axial, radial, and mean diffusivity. FA maps were used to assess CST asymmetry index (CST‐AI). Fisher's exact tests for categorical variables, two‐sample t ‐tests for normally distributed numerical data, and Wilcoxon rank sums for non‐normally distributed numeric data were used. Results A total of 21 patients were enrolled in the study with a mean age of 66 (±14) years and median baseline upper extremity motor component score (UE‐FM) of 42 (median) [range: 23, 53]. Baseline UE‐FM was not predictive of a 10‐point change at 90 days ( p = 0.4469). CST‐AI was predictive of recovery at 15 days ( p = 0.0373), and axial diffusivity was predictive of recovery at 90 days ( p = 0.0402). All other imaging variables did not predict recovery. Conclusion Our data suggest that upper extremity motor recovery after acute ischemic stroke is impacted by CST integrity. Further studies are needed to validate our findings. 10.1111/jon.70095 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Corticospinal Tract Injury Leads to Poor Motor Recovery Immediately After Ischemic Stroke |
| topic | Journal of Neuroimaging |
| url | https://onlinelibrary.wiley.com/doi/10.1111/jon.70095 |