Numerical Investigation of Hemodynamic Factors in Cellular Blood Flow: Insights From Curved Microvessels
Fuente:
Wiley Open Access
Salvato in:
| Autori principali: | , |
|---|---|
| Natura: | Artículo Open Access |
| Pubblicazione: |
Wiley
2025
|
| Soggetti: | |
| Accesso online: | |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne!!
|
| _version_ | 1867018518784901120 |
|---|---|
| author | Mojtaba Amir Aslan Pour Wenbin Mao |
| author_facet | Mojtaba Amir Aslan Pour Wenbin Mao Mojtaba Amir Aslan Pour Wenbin Mao |
| collection | Wiley Open Access |
| contents | Numerical Investigation of Hemodynamic Factors in Cellular Blood Flow: Insights From Curved Microvessels Mojtaba Amir Aslan Pour Wenbin Mao Microcirculation ABSTRACTObjectiveThis study investigates the effects of hemodynamic factors on blood cell suspension flows and their properties in curved microvessels. A parametric study is employed to compare these properties between curved and straight vessels.MethodsA 3D fluid solver coupled with a cell membrane modeling framework via the immersed boundary method was used to simulate cell‐resolved blood flow in straight and curved vessels featuring a 90° bend with moderate curvature.ResultsBlood flow in curved vessels shows lower and higher shear rates in the inner and outer bulk regions, respectively, compared to straight vessels. Asymmetry in hematocrit profiles is linked to less dense suspensions, smaller diameters, and higher Capillary numbers, while the maximum velocity location remains consistent with straight vessels. At physiological shear rates, moderate curvatures, and large diameters, curvature has minimal impact on apparent viscosity. However, diffusivity is elevated at the center of curved vessels compared to straight ones.ConclusionsThis study reveals new insights into blood suspension flows in curved microvessels with a 90° bend, highlighting key differences from straight vessels under certain hemodynamic conditions. These findings lay the groundwork for future research on realistic microvessel geometries and their implications. 10.1111/micc.70013 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/micc.70013 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_micc_70013 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Numerical Investigation of Hemodynamic Factors in Cellular Blood Flow: Insights From Curved Microvessels Mojtaba Amir Aslan Pour Wenbin Mao Microcirculation Numerical Investigation of Hemodynamic Factors in Cellular Blood Flow: Insights From Curved Microvessels Mojtaba Amir Aslan Pour Wenbin Mao Microcirculation ABSTRACTObjectiveThis study investigates the effects of hemodynamic factors on blood cell suspension flows and their properties in curved microvessels. A parametric study is employed to compare these properties between curved and straight vessels.MethodsA 3D fluid solver coupled with a cell membrane modeling framework via the immersed boundary method was used to simulate cell‐resolved blood flow in straight and curved vessels featuring a 90° bend with moderate curvature.ResultsBlood flow in curved vessels shows lower and higher shear rates in the inner and outer bulk regions, respectively, compared to straight vessels. Asymmetry in hematocrit profiles is linked to less dense suspensions, smaller diameters, and higher Capillary numbers, while the maximum velocity location remains consistent with straight vessels. At physiological shear rates, moderate curvatures, and large diameters, curvature has minimal impact on apparent viscosity. However, diffusivity is elevated at the center of curved vessels compared to straight ones.ConclusionsThis study reveals new insights into blood suspension flows in curved microvessels with a 90° bend, highlighting key differences from straight vessels under certain hemodynamic conditions. These findings lay the groundwork for future research on realistic microvessel geometries and their implications. 10.1111/micc.70013 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Numerical Investigation of Hemodynamic Factors in Cellular Blood Flow: Insights From Curved Microvessels |
| topic | Microcirculation |
| url | https://onlinelibrary.wiley.com/doi/10.1111/micc.70013 |