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| Autori principali: | , , , |
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| Natura: | Artículo Open Access |
| Pubblicazione: |
Wiley
2024
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| Soggetti: | |
| Accesso online: | https://onlinelibrary.wiley.com/doi/10.1111/ocr.12877 |
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Sommario:
- Inhibition of Orthodontic Relapse by Local Application of Simvastatin‐Loaded Gelatin Hydrogel in a Rabbit Model Niswati Fathmah Rosyida Ika Dewi Ana Pinandi Sri Pudyani Akhmad Kharis Nugroho Orthodontics & Craniofacial Research ABSTRACTObjectivesThis study aims to determine the effect of gelatin–simvastatin hydrogel application on bone remodelling during relapse.Materials and MethodsTwenty‐four rabbits (Oryctolagus cuniculus) were divided into a control group (n = 12) and a treatment group (n = 12). The lower incisors were subjected to orthodontic force and moved distally by an open coil spring. The force (50 cN) was extended for 1 week and retained in a new position for 2 weeks (stabilisation period). The treatment group received a local gelatin–simvastatin hydrogel administration during stabilisation, and the control group received only gelatin hydrogel. The springs were debonded after the stabilisation phase from both groups to facilitate a relapse. The percentage of relapse was measured in a model study using digital callipers. Levels of OPG and RANKL were analysed using ELISA.ResultsThe local application of gelatin–simvastatin hydrogel in the treatment group significantly decreases the relapse percentage and RANKL level. Additionally, the gelatin–simvastatin hydrogel significantly increases the level of OPG and ratio of OPG/RANKL.ConclusionsApplying gelatin–simvastatin hydrogel in the retention period can induce bone formation, inhibit orthodontic relapse and increase tooth stability (in vivo). 10.1111/ocr.12877 http://onlinelibrary.wiley.com/termsAndConditions#vor