Progressed Atrioventricular Block in Immune Checkpoint Inhibitor Induced Myocarditis: A Case Report
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| Format: | Artículo Open Access |
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Wiley
2025
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| _version_ | 1867007265736753152 |
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| author | Dongmei Xie Ting Yan Xin Zhang Xingbin Liu |
| author_facet | Dongmei Xie Ting Yan Xin Zhang Xingbin Liu Dongmei Xie Ting Yan Xin Zhang Xingbin Liu |
| collection | Wiley Open Access |
| contents | Progressed Atrioventricular Block in Immune Checkpoint Inhibitor Induced Myocarditis: A Case Report Dongmei Xie Ting Yan Xin Zhang Xingbin Liu Pacing and Clinical Electrophysiology ABSTRACTImmune checkpoint inhibitor (ICI) has demonstrated promising results in treating various cancers, but its associated cardiotoxicity, especially ICI‐associated myocarditis, presents a serious concern. We reported a case of a 63‐year‐old male who complained of progressive dyspnea after tislelizumab, a novel humanized anti‐PD‐1 monoclonal antibody, for hepatocellular carcinoma. Upon diagnosing ICI‐related myocarditis, corticosteroid therapy was initiated immediately. The elevated biomarkers quickly decreased, but the atrioventricular block progressed from first‐degree to third‐degree, necessitating pacemaker implantation. This is the first report of complete AVB consecutive to tislelizumab‐induced myocarditis, highlighting the importance of early corticosteroid therapy and continuous electrocardiography monitoring. 10.1111/pace.15155 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/pace.15155 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_pace_15155 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Progressed Atrioventricular Block in Immune Checkpoint Inhibitor Induced Myocarditis: A Case Report Dongmei Xie Ting Yan Xin Zhang Xingbin Liu Pacing and Clinical Electrophysiology Progressed Atrioventricular Block in Immune Checkpoint Inhibitor Induced Myocarditis: A Case Report Dongmei Xie Ting Yan Xin Zhang Xingbin Liu Pacing and Clinical Electrophysiology ABSTRACTImmune checkpoint inhibitor (ICI) has demonstrated promising results in treating various cancers, but its associated cardiotoxicity, especially ICI‐associated myocarditis, presents a serious concern. We reported a case of a 63‐year‐old male who complained of progressive dyspnea after tislelizumab, a novel humanized anti‐PD‐1 monoclonal antibody, for hepatocellular carcinoma. Upon diagnosing ICI‐related myocarditis, corticosteroid therapy was initiated immediately. The elevated biomarkers quickly decreased, but the atrioventricular block progressed from first‐degree to third‐degree, necessitating pacemaker implantation. This is the first report of complete AVB consecutive to tislelizumab‐induced myocarditis, highlighting the importance of early corticosteroid therapy and continuous electrocardiography monitoring. 10.1111/pace.15155 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Progressed Atrioventricular Block in Immune Checkpoint Inhibitor Induced Myocarditis: A Case Report |
| topic | Pacing and Clinical Electrophysiology |
| url | https://onlinelibrary.wiley.com/doi/10.1111/pace.15155 |