Drug‐induced liver injury in pediatric age group: Single‐center experience
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Wiley
2025
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| author | Burcu Güven Serhat Yıldırım Zeynep Gökçe Gayretli Aydın Gökçe Pınar Reis İskenderoğlu Tülay Kamaşak Murat Çakır |
| author_facet | Burcu Güven Serhat Yıldırım Zeynep Gökçe Gayretli Aydın Gökçe Pınar Reis İskenderoğlu Tülay Kamaşak Murat Çakır Burcu Güven Serhat Yıldırım Zeynep Gökçe Gayretli Aydın Gökçe Pınar Reis İskenderoğlu Tülay Kamaşak Murat Çakır |
| collection | Wiley Open Access |
| contents | Drug‐induced liver injury in pediatric age group: Single‐center experience Burcu Güven Serhat Yıldırım Zeynep Gökçe Gayretli Aydın Gökçe Pınar Reis İskenderoğlu Tülay Kamaşak Murat Çakır Pediatrics International Abstract Background There is no clear information regarding the frequency of drug‐induced liver injury (DILI) in the pediatric age group. In this study, we aimed to investigate the incidence of DILI in pediatric patients and to determine the drug groups responsible for the etiology of DILI and the factors associated with this disease. Methods The prospective study was conducted in patients aged 0–18 years and diagnosed with DILI. Age, gender, drugs used by the patients, indications for drug use, duration and dosage of drugs, and laboratory parameters were recorded. Liver injury pattern was classified as hepatocellular, mixed and cholestatic type. Results The mean age was 7.8 ± 5.5 years; 187 (62.3%) were male. A total of 90 drugs were found to be responsible for hepatotoxicity, among which methotrexate (8.66%) and cephalosporin group antibiotics (8.66%) were found to be the most commonly identified drugs, followed by carbapenem group antibiotics (6.77%), steroids (6.77%) and mercaptopurine (5.04%). Hepatocellular type developed in 67% ( n = 122), mixed type in 28% ( n = 51) and cholestatic type in 5% ( n = 8) patients. Conclusions Hepatocellular type was found to be the most common type among the patterns of liver injury in the pediatric age group. Although antibiotics constitute the leading cause of DILI, antibiotic choices are changing due to increasing resistant infections. The frequency of carbapenem‐induced DILI is increasing. 10.1111/ped.70099 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/ped.70099 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_ped_70099 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Drug‐induced liver injury in pediatric age group: Single‐center experience Burcu Güven Serhat Yıldırım Zeynep Gökçe Gayretli Aydın Gökçe Pınar Reis İskenderoğlu Tülay Kamaşak Murat Çakır Pediatrics International Drug‐induced liver injury in pediatric age group: Single‐center experience Burcu Güven Serhat Yıldırım Zeynep Gökçe Gayretli Aydın Gökçe Pınar Reis İskenderoğlu Tülay Kamaşak Murat Çakır Pediatrics International Abstract Background There is no clear information regarding the frequency of drug‐induced liver injury (DILI) in the pediatric age group. In this study, we aimed to investigate the incidence of DILI in pediatric patients and to determine the drug groups responsible for the etiology of DILI and the factors associated with this disease. Methods The prospective study was conducted in patients aged 0–18 years and diagnosed with DILI. Age, gender, drugs used by the patients, indications for drug use, duration and dosage of drugs, and laboratory parameters were recorded. Liver injury pattern was classified as hepatocellular, mixed and cholestatic type. Results The mean age was 7.8 ± 5.5 years; 187 (62.3%) were male. A total of 90 drugs were found to be responsible for hepatotoxicity, among which methotrexate (8.66%) and cephalosporin group antibiotics (8.66%) were found to be the most commonly identified drugs, followed by carbapenem group antibiotics (6.77%), steroids (6.77%) and mercaptopurine (5.04%). Hepatocellular type developed in 67% ( n = 122), mixed type in 28% ( n = 51) and cholestatic type in 5% ( n = 8) patients. Conclusions Hepatocellular type was found to be the most common type among the patterns of liver injury in the pediatric age group. Although antibiotics constitute the leading cause of DILI, antibiotic choices are changing due to increasing resistant infections. The frequency of carbapenem‐induced DILI is increasing. 10.1111/ped.70099 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Drug‐induced liver injury in pediatric age group: Single‐center experience |
| topic | Pediatrics International |
| url | https://onlinelibrary.wiley.com/doi/10.1111/ped.70099 |