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| Main Authors: | , , , , , , |
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| Format: | Artículo Open Access |
| Published: |
Wiley
2026
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| Subjects: | |
| Online Access: | https://onlinelibrary.wiley.com/doi/10.1111/ped.70355 |
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- Age‐related variations in prostaglandin E‐major urinary metabolite values in Japanese children Takatoshi Maeyama Ayaka Takashiba Ayaha Hata Keinosuke Hizuka Ryutaro Saura Yuri Etani Shin‐ichiro Hagiwara Pediatrics International Abstract Background Prostaglandin E‐major urinary metabolite (PGE‐MUM) is an emerging noninvasive biomarker used to evaluate clinical and endoscopic activity in patients with inflammatory bowel disease. Previous studies have shown that PGE‐MUM values correlate with colonic inflammation in pediatric ulcerative colitis; however, reference values for children without inflammation have not been defined yet. This study aimed to determine the normal reference values of PGE‐MUM in healthy pediatric subjects without inflammatory conditions. Methods Between December 2018 and January 2022, we prospectively enrolled 221 participants (cross‐sectional study, aged 0–15 years) who were undergoing growth hormone stimulation testing for diagnostic purposes and exhibited no symptoms of inflammation or elevated C‐reactive protein levels at a single pediatric center in Japan. PGE‐MUM values were measured using a chemiluminescent enzyme immunoassay and assessed for age‐ and sex‐related differences. Results A total of 218 participants were included in the analysis. Based on age, the participants were classified as young children (2–6 years, n = 147) and older children (7–14 years, n = 66); the reference ranges for the two groups were identified as 18.4–58.7 μg/g·Cr and 12.4–50.3 μg/g·Cr, respectively. The PGE‐MUM values tended to decrease with increasing age; however, no significant sex‐related differences were observed (median 29.1 μg/g·Cr for boys versus 30.4 μg/g·Cr for girls). Conclusions Healthy pediatric subjects generally have higher PGE‐MUM values than healthy adults, with particularly elevated values in young children (2–6 years). These observations suggest that age‐related variability must be taken into account when using PGE‐MUM as a biomarker in young children with ulcerative colitis. 10.1111/ped.70355 http://creativecommons.org/licenses/by/4.0/