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| Format: | Artículo Open Access |
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Wiley
2024
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| Online-Zugang: | https://onlinelibrary.wiley.com/doi/10.1111/php.13951 |
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| author | Pranav Volety Carl A. Shirley Gagan Chhabra Nihal Ahmad |
| author_facet | Pranav Volety Carl A. Shirley Gagan Chhabra Nihal Ahmad Pranav Volety Carl A. Shirley Gagan Chhabra Nihal Ahmad |
| collection | Wiley Open Access |
| contents | The fusion of light and immunity: Advancements in photoimmunotherapy for melanoma Pranav Volety Carl A. Shirley Gagan Chhabra Nihal Ahmad Photochemistry and Photobiology AbstractMetastatic melanoma is an aggressive skin cancer with high mortality and recurrence rates. Despite the clinical success of recent immunotherapy approaches, prevailing resistance rates necessitate the continued development of novel therapeutic options. Photoimmunotherapy (PIT) is emerging as a promising immunotherapy strategy that uses photodynamic therapy (PDT) to unleash systemic immune responses against tumor sites while maintaining the superior tumor‐specificity and minimally invasive nature of traditional PDT. In this review, we discuss recent advances in PIT and strategies for the management of melanoma using PIT. PIT can strongly induce immunogenic cell death, inviting the concomitant application of immune checkpoint blockade or adoptive cell therapies. PIT can also be leveraged to selectively remove the suppressive immune populations associated with immunotherapy resistance. The modular nature of PIT therapy design combined with the potential for patient‐specific antigen selection or drug co‐delivery makes PIT an alluring option for future personalized melanoma care. 10.1111/php.13951 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/php.13951 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_php_13951 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | The fusion of light and immunity: Advancements in photoimmunotherapy for melanoma Pranav Volety Carl A. Shirley Gagan Chhabra Nihal Ahmad Photochemistry and Photobiology The fusion of light and immunity: Advancements in photoimmunotherapy for melanoma Pranav Volety Carl A. Shirley Gagan Chhabra Nihal Ahmad Photochemistry and Photobiology AbstractMetastatic melanoma is an aggressive skin cancer with high mortality and recurrence rates. Despite the clinical success of recent immunotherapy approaches, prevailing resistance rates necessitate the continued development of novel therapeutic options. Photoimmunotherapy (PIT) is emerging as a promising immunotherapy strategy that uses photodynamic therapy (PDT) to unleash systemic immune responses against tumor sites while maintaining the superior tumor‐specificity and minimally invasive nature of traditional PDT. In this review, we discuss recent advances in PIT and strategies for the management of melanoma using PIT. PIT can strongly induce immunogenic cell death, inviting the concomitant application of immune checkpoint blockade or adoptive cell therapies. PIT can also be leveraged to selectively remove the suppressive immune populations associated with immunotherapy resistance. The modular nature of PIT therapy design combined with the potential for patient‐specific antigen selection or drug co‐delivery makes PIT an alluring option for future personalized melanoma care. 10.1111/php.13951 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | The fusion of light and immunity: Advancements in photoimmunotherapy for melanoma |
| topic | Photochemistry and Photobiology |
| url | https://onlinelibrary.wiley.com/doi/10.1111/php.13951 |