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| Format: | Artículo Open Access |
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Wiley
2025
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| Online-Zugang: | https://onlinelibrary.wiley.com/doi/10.1111/php.14078 |
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| author | Jiejun Han Rongyue Gong Yuankun Liu Tiangui Gong Bin Wang Laidi Zhang Jiayue Chen |
| author_facet | Jiejun Han Rongyue Gong Yuankun Liu Tiangui Gong Bin Wang Laidi Zhang Jiayue Chen Jiejun Han Rongyue Gong Yuankun Liu Tiangui Gong Bin Wang Laidi Zhang Jiayue Chen |
| collection | Wiley Open Access |
| contents | A novel microcapsule composite Spherulites Peony Superior Retinol mitigates UVB‐induced skin damage in vitro and in vivo Jiejun Han Rongyue Gong Yuankun Liu Tiangui Gong Bin Wang Laidi Zhang Jiayue Chen Photochemistry and Photobiology Abstract Skin serves as our outermost barrier, protecting our bodies from various environmental damages. Increasing research has revealed that UVB is a primary factor for extrinsic aging. This study explored the role of a novel microcapsule composite Spherulites Peony Superior Retinol (SPSR) on skin damage induced by UVB. SPSR exhibited a capacity to eliminate UVB‐induced ROS. By measurement of cyclobutane pyrimidine dimers (CPD) and comet assay, the results implied that SPSR mitigates DNA damage from oxidative damage caused by UVB. In addition, UVB radiation typically leads to an increase in inflammatory factors within the skin. Decreased gene expressions of interleukin‐1α and TNF‐α have been observed in HaCaT cells. Moreover, a decreased gene expression of extracellular matrix (ECM)‐related protein, including fibronectin ( FN1 ), Col1A1 , and Col3A1 caused by UVB was mitigated by SPSR. Furthermore, the clinical trials with 30 volunteers confirmed the significant relief and antiwrinkle effects of the cosmetic formulation containing 0.1% SPSR. These findings implied the promising potential of SPSR as a comprehensive solution for combating the detrimental effects of UVB exposure and maintaining skin health. 10.1111/php.14078 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1111/php.14078 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_php_14078 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2025 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | A novel microcapsule composite Spherulites Peony Superior Retinol mitigates UVB‐induced skin damage in vitro and in vivo Jiejun Han Rongyue Gong Yuankun Liu Tiangui Gong Bin Wang Laidi Zhang Jiayue Chen Photochemistry and Photobiology A novel microcapsule composite Spherulites Peony Superior Retinol mitigates UVB‐induced skin damage in vitro and in vivo Jiejun Han Rongyue Gong Yuankun Liu Tiangui Gong Bin Wang Laidi Zhang Jiayue Chen Photochemistry and Photobiology Abstract Skin serves as our outermost barrier, protecting our bodies from various environmental damages. Increasing research has revealed that UVB is a primary factor for extrinsic aging. This study explored the role of a novel microcapsule composite Spherulites Peony Superior Retinol (SPSR) on skin damage induced by UVB. SPSR exhibited a capacity to eliminate UVB‐induced ROS. By measurement of cyclobutane pyrimidine dimers (CPD) and comet assay, the results implied that SPSR mitigates DNA damage from oxidative damage caused by UVB. In addition, UVB radiation typically leads to an increase in inflammatory factors within the skin. Decreased gene expressions of interleukin‐1α and TNF‐α have been observed in HaCaT cells. Moreover, a decreased gene expression of extracellular matrix (ECM)‐related protein, including fibronectin ( FN1 ), Col1A1 , and Col3A1 caused by UVB was mitigated by SPSR. Furthermore, the clinical trials with 30 volunteers confirmed the significant relief and antiwrinkle effects of the cosmetic formulation containing 0.1% SPSR. These findings implied the promising potential of SPSR as a comprehensive solution for combating the detrimental effects of UVB exposure and maintaining skin health. 10.1111/php.14078 http://creativecommons.org/licenses/by/4.0/ |
| title | A novel microcapsule composite Spherulites Peony Superior Retinol mitigates UVB‐induced skin damage in vitro and in vivo |
| topic | Photochemistry and Photobiology |
| url | https://onlinelibrary.wiley.com/doi/10.1111/php.14078 |