Effect of long‐term oral administration of the flavonoid quercetin on the antioxidant profile of young and adult reproductive rabbit does
Fuente:
Wiley Open Access
Enregistré dans:
| Auteurs principaux: | , , , , , , , |
|---|---|
| Format: | Artículo Open Access |
| Publié: |
Wiley
2024
|
| Sujets: | |
| Accès en ligne: | |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
| _version_ | 1867016611274162176 |
|---|---|
| author | A. Vicente‐Carrillo D. Jordán‐Rodríguez E. Cáceres‐Martín A. Gómez‐León P. G. Rebollar P. L. Lorenzo R. M. García‐García M. Arias‐Álvarez |
| author_facet | A. Vicente‐Carrillo D. Jordán‐Rodríguez E. Cáceres‐Martín A. Gómez‐León P. G. Rebollar P. L. Lorenzo R. M. García‐García M. Arias‐Álvarez A. Vicente‐Carrillo D. Jordán‐Rodríguez E. Cáceres‐Martín A. Gómez‐León P. G. Rebollar P. L. Lorenzo R. M. García‐García M. Arias‐Álvarez |
| collection | Wiley Open Access |
| contents | Effect of long‐term oral administration of the flavonoid quercetin on the antioxidant profile of young and adult reproductive rabbit does A. Vicente‐Carrillo D. Jordán‐Rodríguez E. Cáceres‐Martín A. Gómez‐León P. G. Rebollar P. L. Lorenzo R. M. García‐García M. Arias‐Álvarez Reproduction in Domestic Animals AbstractIn industrialized farms, rabbit does undergo intensive production rhythms which overlap lactation and gestation, leading to a high energy mobilization and increasing oxidative stress. Accordingly, we hypothesize that administration of the flavonoid quercetin (QUR) may improve the antioxidant status of young and adult rabbit reproductive females. In this study, the effect of daily oral administration of 300 mg/kg QUR for 8 weeks was assessed on the antioxidant profile of 24 New Zealand × Californian rabbit does, assigned to 4 experimental groups: rearing young (8–16 weeks old) and adult does at the end of their reproductive life (12–14 months old, with at least 3–4 reproductive cycles) treated (YQ and AQ) or not (YC and AC) with QUR, respectively. Plasma glutathione (GSH), as well as serum superoxide dismutase (SOD) and malondialdehyde (MDA) were measured during the experimental period. To assess the health status of the animals, a physical examination was also performed. GSH plasma concentrations were significantly higher in young does at weeks 1 and 4, but not at week 8 of the experiment, irrespectively of QUR administration. An increase in GSH plasma concentration was observed during the 8‐week experiment in both AQ and AC groups. Furthermore, QUR administration did not alter either SOD or MDA serum activity and concentration in any group during the experimental period. Physical examination revealed no differences between the experimental groups. In conclusion, under our experimental conditions, QUR did not modify the general clinical or the antioxidant profile of young and adult reproductive rabbit females. 10.1111/rda.14639 http://creativecommons.org/licenses/by/4.0/ |
| doi_str_mv | 10.1111/rda.14639 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_rda_14639 |
| institution | Wiley Open Access |
| license_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Effect of long‐term oral administration of the flavonoid quercetin on the antioxidant profile of young and adult reproductive rabbit does A. Vicente‐Carrillo D. Jordán‐Rodríguez E. Cáceres‐Martín A. Gómez‐León P. G. Rebollar P. L. Lorenzo R. M. García‐García M. Arias‐Álvarez Reproduction in Domestic Animals Effect of long‐term oral administration of the flavonoid quercetin on the antioxidant profile of young and adult reproductive rabbit does A. Vicente‐Carrillo D. Jordán‐Rodríguez E. Cáceres‐Martín A. Gómez‐León P. G. Rebollar P. L. Lorenzo R. M. García‐García M. Arias‐Álvarez Reproduction in Domestic Animals AbstractIn industrialized farms, rabbit does undergo intensive production rhythms which overlap lactation and gestation, leading to a high energy mobilization and increasing oxidative stress. Accordingly, we hypothesize that administration of the flavonoid quercetin (QUR) may improve the antioxidant status of young and adult rabbit reproductive females. In this study, the effect of daily oral administration of 300 mg/kg QUR for 8 weeks was assessed on the antioxidant profile of 24 New Zealand × Californian rabbit does, assigned to 4 experimental groups: rearing young (8–16 weeks old) and adult does at the end of their reproductive life (12–14 months old, with at least 3–4 reproductive cycles) treated (YQ and AQ) or not (YC and AC) with QUR, respectively. Plasma glutathione (GSH), as well as serum superoxide dismutase (SOD) and malondialdehyde (MDA) were measured during the experimental period. To assess the health status of the animals, a physical examination was also performed. GSH plasma concentrations were significantly higher in young does at weeks 1 and 4, but not at week 8 of the experiment, irrespectively of QUR administration. An increase in GSH plasma concentration was observed during the 8‐week experiment in both AQ and AC groups. Furthermore, QUR administration did not alter either SOD or MDA serum activity and concentration in any group during the experimental period. Physical examination revealed no differences between the experimental groups. In conclusion, under our experimental conditions, QUR did not modify the general clinical or the antioxidant profile of young and adult reproductive rabbit females. 10.1111/rda.14639 http://creativecommons.org/licenses/by/4.0/ |
| title | Effect of long‐term oral administration of the flavonoid quercetin on the antioxidant profile of young and adult reproductive rabbit does |
| topic | Reproduction in Domestic Animals |
| url | https://onlinelibrary.wiley.com/doi/10.1111/rda.14639 |