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| Main Authors: | , , , , , , , |
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| Format: | Artículo Open Access |
| Published: |
Wiley
2024
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| Subjects: | |
| Online Access: | https://onlinelibrary.wiley.com/doi/10.1111/resp.14799 |
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Table of Contents:
- COPD is associated with increased cardiovascular disease risk independent of phenotype Kolton Cobb Jonathan Kenyon Juan Lu Benjamin Krieger Apostolos Perelas Patrick Nana‐Sinkam Youngdeok Kim Paula Rodriguez‐Miguelez Respirology AbstractBackground and ObjectiveChronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide that frequently presents with concomitant cardiovascular diseases. Despite the pathological distinction between individual COPD phenotypes such as emphysema and chronic bronchitis, there is a lack of knowledge about the impact of COPD phenotype on cardiovascular disease risk. Thus, this study aimed to utilize a nationally representative sample to investigate cardiovascular disease prevalence in patients with COPD with emphysema and chronic bronchitis phenotypes.MethodsData from 31,560 adults including 2504 individuals with COPD, collected as part of the National Health and Nutrition Examination Survey (1999–2018), were examined.ResultsA significantly increased cardiovascular disease risk, including coronary heart disease, heart failure, myocardial infarction and stroke, was identified in patients with COPD among all disease phenotypes. Particularly, compared to those without COPD, individuals with chronic bronchitis presented with 1.76 (95% CI: 1.41–2.20) times greater odds, individuals with emphysema with 2.31 (95% CI: 1.80–2.96) times greater odds, while those with a concurrent phenotype (combined chronic bronchitis and emphysema) exhibited 2.98 (95% CI: 2.11–4.21) times greater odds of reporting cardiovascular diseases.ConclusionOur data confirms that patients with COPD present an elevated risk of developing cardiovascular disease among all phenotypes, with the most marked increase being in those with concurrent chronic bronchitis and emphysema phenotypes. These findings emphasize the need for awareness and appropriate cardiovascular screening in COPD.image 10.1111/resp.14799 http://creativecommons.org/licenses/by-nc-nd/4.0/