Hepatitis B vaccine responders show higher frequencies of CD8+ effector memory and central memory T cells compared to non‐responders
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2024
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| author | Mahsa Eshkevar Vakili Niloofar Mashhadi Mohammad Reza Ataollahi Seppo Meri Dieter Kabelitz Kurosh Kalantar |
| author_facet | Mahsa Eshkevar Vakili Niloofar Mashhadi Mohammad Reza Ataollahi Seppo Meri Dieter Kabelitz Kurosh Kalantar Mahsa Eshkevar Vakili Niloofar Mashhadi Mohammad Reza Ataollahi Seppo Meri Dieter Kabelitz Kurosh Kalantar |
| collection | Wiley Open Access |
| contents | Hepatitis B vaccine responders show higher frequencies of CD8+ effector memory and central memory T cells compared to non‐responders Mahsa Eshkevar Vakili Niloofar Mashhadi Mohammad Reza Ataollahi Seppo Meri Dieter Kabelitz Kurosh Kalantar Scandinavian Journal of Immunology AbstractHepatitis B (HB) infection is a major global health problem. There is limited knowledge about HB vaccination‐induced immune memory responses. We compared the frequency of CD8+ memory T cell subsets between responders (RSs) and non‐responders (NRs) to HB vaccination. Blood samples were collected from RSs and NRs. PBMCs were cultured in the presence of Hepatitis B surface antigens (HBsAg) and PHA for 48 h to restimulate CD8+ memory T cells and T cell memory subsets were detected by flow cytometry using memory cell markers. The frequency of TEM, TCM, and TCMhi was significantly higher in responders compared to non‐responders (p = 0.024, 0.022, and 0.047, respectively). Additionally, we report a positive correlation between the frequency of TEM cells in RSs with age and anti‐HBsAb level (p = 0.03 and rs = 0.5; p = 0.01 and rs = 0.06). Responders display a higher level of CD8+ T cell‐mediated immunity. Therefore, we suggest a possible defect in the formation of immunological CD8+ memory T cells in NRs and it may reduce antibody production compared to the RSs, although more experiments are needed. 10.1111/sji.13402 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/sji.13402 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_sji_13402 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Hepatitis B vaccine responders show higher frequencies of CD8+ effector memory and central memory T cells compared to non‐responders Mahsa Eshkevar Vakili Niloofar Mashhadi Mohammad Reza Ataollahi Seppo Meri Dieter Kabelitz Kurosh Kalantar Scandinavian Journal of Immunology Hepatitis B vaccine responders show higher frequencies of CD8+ effector memory and central memory T cells compared to non‐responders Mahsa Eshkevar Vakili Niloofar Mashhadi Mohammad Reza Ataollahi Seppo Meri Dieter Kabelitz Kurosh Kalantar Scandinavian Journal of Immunology AbstractHepatitis B (HB) infection is a major global health problem. There is limited knowledge about HB vaccination‐induced immune memory responses. We compared the frequency of CD8+ memory T cell subsets between responders (RSs) and non‐responders (NRs) to HB vaccination. Blood samples were collected from RSs and NRs. PBMCs were cultured in the presence of Hepatitis B surface antigens (HBsAg) and PHA for 48 h to restimulate CD8+ memory T cells and T cell memory subsets were detected by flow cytometry using memory cell markers. The frequency of TEM, TCM, and TCMhi was significantly higher in responders compared to non‐responders (p = 0.024, 0.022, and 0.047, respectively). Additionally, we report a positive correlation between the frequency of TEM cells in RSs with age and anti‐HBsAb level (p = 0.03 and rs = 0.5; p = 0.01 and rs = 0.06). Responders display a higher level of CD8+ T cell‐mediated immunity. Therefore, we suggest a possible defect in the formation of immunological CD8+ memory T cells in NRs and it may reduce antibody production compared to the RSs, although more experiments are needed. 10.1111/sji.13402 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Hepatitis B vaccine responders show higher frequencies of CD8+ effector memory and central memory T cells compared to non‐responders |
| topic | Scandinavian Journal of Immunology |
| url | https://onlinelibrary.wiley.com/doi/10.1111/sji.13402 |