Comparison of intradermal and serum testing for environmental allergen‐specific immunoglobulin E determination in a laboratory colony of cats with naturally acquired atopic syndrome
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| Format: | Artículo Open Access |
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Wiley
2024
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| _version_ | 1867016442608615424 |
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| author | Julie Lefrançois Colombe Otis Maxim Moreau Marike Visser Lauren Bessey Andrea Gonzales Jean‐Pierre Pelletier Johanne Martel‐Pelletier Eric Troncy Frédéric Sauvé |
| author_facet | Julie Lefrançois Colombe Otis Maxim Moreau Marike Visser Lauren Bessey Andrea Gonzales Jean‐Pierre Pelletier Johanne Martel‐Pelletier Eric Troncy Frédéric Sauvé Julie Lefrançois Colombe Otis Maxim Moreau Marike Visser Lauren Bessey Andrea Gonzales Jean‐Pierre Pelletier Johanne Martel‐Pelletier Eric Troncy Frédéric Sauvé |
| collection | Wiley Open Access |
| contents | Comparison of intradermal and serum testing for environmental allergen‐specific immunoglobulin E determination in a laboratory colony of cats with naturally acquired atopic syndrome Julie Lefrançois Colombe Otis Maxim Moreau Marike Visser Lauren Bessey Andrea Gonzales Jean‐Pierre Pelletier Johanne Martel‐Pelletier Eric Troncy Frédéric Sauvé Veterinary Dermatology AbstractBackgroundAllergen testing is used to select antigens included in the desensitisation vaccine. Intradermal skin test (IDT) is the gold standard in cats, yet allergen‐specific immunoglobulin (Ig)E serological testing (ASIS) is often used. Feline data are lacking regarding the agreement between IDT and ASIS results.Hypothesis/ObjectivesThe first objective of the study was to establish a colony of cats with naturally acquired feline atopic syndrome (FAS). Further objectives were to define their hypersensitivity disorder to detail the allergen tests results, and to assess similarity between the allergen tests.AnimalsThirty‐five cats with FAS and 10 control cats.Materials and MethodsEnrolled cats went through a five phase‐screening and quarantine process before joining the colony. An elimination diet trial was performed on all FAS cats. ASIS and IDT were consecutively performed on all cats under sedation.ResultsReactions to 34 allergens were compiled for the 45 cats. Global sensitivity and specificity of ASIS were 34.7% and 78.9%, respectively. Only flea (ICC = 0.26, p = 0.040) and Dermatophagoides pteronyssinus (ICC = 0.48, p < 0.001) allergens had a significant intraclass correlation (weak agreement). Two FAS cats had negative tests including one cat with a concomitant food allergy.Conclusions and Clinical RelevanceThis study depicts the first reported colony of cats with naturally acquired FAS. This is the first feline study to compare and show the poor agreement between allergen tests with a panel of 34 allergens. This colony also harbours two cats with FAS with negative allergen tests. These may represent the first described cats with an intrinsic form of atopic syndrome. 10.1111/vde.13232 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/vde.13232 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_vde_13232 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Comparison of intradermal and serum testing for environmental allergen‐specific immunoglobulin E determination in a laboratory colony of cats with naturally acquired atopic syndrome Julie Lefrançois Colombe Otis Maxim Moreau Marike Visser Lauren Bessey Andrea Gonzales Jean‐Pierre Pelletier Johanne Martel‐Pelletier Eric Troncy Frédéric Sauvé Veterinary Dermatology Comparison of intradermal and serum testing for environmental allergen‐specific immunoglobulin E determination in a laboratory colony of cats with naturally acquired atopic syndrome Julie Lefrançois Colombe Otis Maxim Moreau Marike Visser Lauren Bessey Andrea Gonzales Jean‐Pierre Pelletier Johanne Martel‐Pelletier Eric Troncy Frédéric Sauvé Veterinary Dermatology AbstractBackgroundAllergen testing is used to select antigens included in the desensitisation vaccine. Intradermal skin test (IDT) is the gold standard in cats, yet allergen‐specific immunoglobulin (Ig)E serological testing (ASIS) is often used. Feline data are lacking regarding the agreement between IDT and ASIS results.Hypothesis/ObjectivesThe first objective of the study was to establish a colony of cats with naturally acquired feline atopic syndrome (FAS). Further objectives were to define their hypersensitivity disorder to detail the allergen tests results, and to assess similarity between the allergen tests.AnimalsThirty‐five cats with FAS and 10 control cats.Materials and MethodsEnrolled cats went through a five phase‐screening and quarantine process before joining the colony. An elimination diet trial was performed on all FAS cats. ASIS and IDT were consecutively performed on all cats under sedation.ResultsReactions to 34 allergens were compiled for the 45 cats. Global sensitivity and specificity of ASIS were 34.7% and 78.9%, respectively. Only flea (ICC = 0.26, p = 0.040) and Dermatophagoides pteronyssinus (ICC = 0.48, p < 0.001) allergens had a significant intraclass correlation (weak agreement). Two FAS cats had negative tests including one cat with a concomitant food allergy.Conclusions and Clinical RelevanceThis study depicts the first reported colony of cats with naturally acquired FAS. This is the first feline study to compare and show the poor agreement between allergen tests with a panel of 34 allergens. This colony also harbours two cats with FAS with negative allergen tests. These may represent the first described cats with an intrinsic form of atopic syndrome. 10.1111/vde.13232 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Comparison of intradermal and serum testing for environmental allergen‐specific immunoglobulin E determination in a laboratory colony of cats with naturally acquired atopic syndrome |
| topic | Veterinary Dermatology |
| url | https://onlinelibrary.wiley.com/doi/10.1111/vde.13232 |