Evaluation of the safety and effect of lyophilized canine‐specific albumin to increase serum albumin concentration and colloid osmotic pressure in healthy dogs
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2024
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| author | Brittany D. Enders Sarah E. Musulin Marie K. Holowaychuk Anne S. Hale |
| author_facet | Brittany D. Enders Sarah E. Musulin Marie K. Holowaychuk Anne S. Hale Brittany D. Enders Sarah E. Musulin Marie K. Holowaychuk Anne S. Hale |
| collection | Wiley Open Access |
| contents | Evaluation of the safety and effect of lyophilized canine‐specific albumin to increase serum albumin concentration and colloid osmotic pressure in healthy dogs Brittany D. Enders Sarah E. Musulin Marie K. Holowaychuk Anne S. Hale Journal of Veterinary Emergency and Critical Care AbstractObjectiveTo evaluate the safety of repeated administration of a lyophilized canine‐specific albumin (CSA) product and to quantify its effect on serum albumin concentrations and colloid osmotic pressure (COP) in healthy dogs.DesignProspective study.SettingUniversity research facility.AnimalsSix healthy, adult, purpose‐bred Beagles.InterventionsDogs received 1 g/kg of 16% CSA intravenously on days 1, 2, and 14 and were observed, with serial measurement of vital parameters during and for 2 hours after each infusion, to monitor for adverse events or evidence of a hypersensitivity reaction. Serum albumin concentration and COP were measured at predetermined time points before and after each infusion.ResultsOne dog experienced a single episode of vomiting approximately 1 hour after completion of the second infusion. No other adverse reactions were observed during the 28‐day study period. Serum albumin concentration was increased by a mean of 0.57 g/dL (5.7 g/L) (P = 0.003) when measured 2 hours after the first CSA infusion, and albumin concentration remained significantly higher than baseline at 24 hours after infusion, with a mean difference of 0.42 g/dL (4.2 g/dL) (P < 0.001). The second and third CSA infusions similarly increased serum albumin concentration at 2 hours (P = 0.001 and P = 0.001, respectively) and 24 hours (P = 0.012 and P = 0.007, respectively) after infusion. COP increased by a mean of 2.03 mm Hg at 2 hours after the first infusion (P = 0.013) and remained significantly higher than baseline at 24 hours after infusion, with a mean difference of 1.52 mm Hg (P = 0.002). The second CSA infusion similarly increased COP at 2 hours (P < 0.001) and 24 hours (P = 0.017) after infusion. The third CSA infusion increased COP at 2 hours after infusion (P = 0.004) but did not achieve statistical significance at 24 hours after infusion (P = 0.053).ConclusionsA 1‐g/kg dose of lyophilized CSA was effective at increasing serum albumin concentration and COP. Repeated infusions of CSA appear safe in healthy dogs. 10.1111/vec.13432 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/vec.13432 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_vec_13432 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
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| spellingShingle | Evaluation of the safety and effect of lyophilized canine‐specific albumin to increase serum albumin concentration and colloid osmotic pressure in healthy dogs Brittany D. Enders Sarah E. Musulin Marie K. Holowaychuk Anne S. Hale Journal of Veterinary Emergency and Critical Care Evaluation of the safety and effect of lyophilized canine‐specific albumin to increase serum albumin concentration and colloid osmotic pressure in healthy dogs Brittany D. Enders Sarah E. Musulin Marie K. Holowaychuk Anne S. Hale Journal of Veterinary Emergency and Critical Care AbstractObjectiveTo evaluate the safety of repeated administration of a lyophilized canine‐specific albumin (CSA) product and to quantify its effect on serum albumin concentrations and colloid osmotic pressure (COP) in healthy dogs.DesignProspective study.SettingUniversity research facility.AnimalsSix healthy, adult, purpose‐bred Beagles.InterventionsDogs received 1 g/kg of 16% CSA intravenously on days 1, 2, and 14 and were observed, with serial measurement of vital parameters during and for 2 hours after each infusion, to monitor for adverse events or evidence of a hypersensitivity reaction. Serum albumin concentration and COP were measured at predetermined time points before and after each infusion.ResultsOne dog experienced a single episode of vomiting approximately 1 hour after completion of the second infusion. No other adverse reactions were observed during the 28‐day study period. Serum albumin concentration was increased by a mean of 0.57 g/dL (5.7 g/L) (P = 0.003) when measured 2 hours after the first CSA infusion, and albumin concentration remained significantly higher than baseline at 24 hours after infusion, with a mean difference of 0.42 g/dL (4.2 g/dL) (P < 0.001). The second and third CSA infusions similarly increased serum albumin concentration at 2 hours (P = 0.001 and P = 0.001, respectively) and 24 hours (P = 0.012 and P = 0.007, respectively) after infusion. COP increased by a mean of 2.03 mm Hg at 2 hours after the first infusion (P = 0.013) and remained significantly higher than baseline at 24 hours after infusion, with a mean difference of 1.52 mm Hg (P = 0.002). The second CSA infusion similarly increased COP at 2 hours (P < 0.001) and 24 hours (P = 0.017) after infusion. The third CSA infusion increased COP at 2 hours after infusion (P = 0.004) but did not achieve statistical significance at 24 hours after infusion (P = 0.053).ConclusionsA 1‐g/kg dose of lyophilized CSA was effective at increasing serum albumin concentration and COP. Repeated infusions of CSA appear safe in healthy dogs. 10.1111/vec.13432 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Evaluation of the safety and effect of lyophilized canine‐specific albumin to increase serum albumin concentration and colloid osmotic pressure in healthy dogs |
| topic | Journal of Veterinary Emergency and Critical Care |
| url | https://onlinelibrary.wiley.com/doi/10.1111/vec.13432 |