Comparison of intranasal atipamezole by atomization or drops with intramuscular injection for reversing sedative effects of medetomidine in healthy dogs
Fuente:
Wiley Open Access
Enregistré dans:
| Auteurs principaux: | , , , , |
|---|---|
| Format: | Artículo Open Access |
| Publié: |
Wiley
2024
|
| Sujets: | |
| Accès en ligne: | |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
| _version_ | 1867007537669210112 |
|---|---|
| author | Majid Jafarbeglou Mehdi Marjani Mohammadreza Oghbaei Mohammadreza Paryani Reza Bakhshi‐Khanghah |
| author_facet | Majid Jafarbeglou Mehdi Marjani Mohammadreza Oghbaei Mohammadreza Paryani Reza Bakhshi‐Khanghah Majid Jafarbeglou Mehdi Marjani Mohammadreza Oghbaei Mohammadreza Paryani Reza Bakhshi‐Khanghah |
| collection | Wiley Open Access |
| contents | Comparison of intranasal atipamezole by atomization or drops with intramuscular injection for reversing sedative effects of medetomidine in healthy dogs Majid Jafarbeglou Mehdi Marjani Mohammadreza Oghbaei Mohammadreza Paryani Reza Bakhshi‐Khanghah Journal of Veterinary Emergency and Critical Care AbstractObjectiveTo determine and compare the efficacy of intranasal (IN) atomization, IN drops, and IM injection of atipamezole for reversal of medetomidine‐induced sedation in healthy dogs.DesignProspective, randomized, blinded study.SettingUniversity teaching hospital.AnimalsForty mixed‐breed, shelter‐owned dogs with an average weight of 29.9 ± 5.6 kg (mean ± SD) that required sedation for minor diagnostic or therapeutic procedures.InterventionsAtipamezole was administered by a dog handler at 200 µg/kg via IN atomization (ATI‐INA, n = 10), IN drops (ATI‐IND, n = 10), or IM injection (ATI‐IM, n = 10) 20 minutes following medetomidine administration (40 µg/kg). A control group (n = 10) received no atipamezole.Measurements and Main ResultsEase of atipamezole administration was evaluated. Sedation score, heart rate (HR), respiratory rate (RR), and blood pressure (BP) were recorded pre‐medetomidine administration (T0), pre‐atipamezole administration (T20), and at multiple intervals following atipamezole administration. ATI‐IM resulted in the fastest recovery, followed by ATI‐INA, with ATI‐IND being the slowest. The adverse cardiovascular impacts of medetomidine were not completely mitigated. ATI‐IM showed initial HR restoration followed by a decline. HR in both IN groups showed a slower increase compared to ATI‐IM, but no subsequent decline was observed. ATI‐IM resulted in a transient decrease in BP, though dogs remained normotensive. A gradual reduction in BP was noted in the IN groups. At T50, RR of all atipamezole groups differed from control, and a significant increase in RR was observed in ATI‐IM dogs compared to pre‐atipamezole value. No adverse effects were observed.ConclusionsAll routes for atipamezole administration effectively reversed medetomidine‐induced sedation, with ATI‐IM being fastest. IN routes were easy for the dog handler to administer, making them viable alternatives in cases of accidental drug exposure, particularly outside a hospital setting. 10.1111/vec.13439 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| doi_str_mv | 10.1111/vec.13439 |
| format | Artículo Open Access |
| id | wiley_oa_10_1111_vec_13439 |
| institution | Wiley Open Access |
| license_str_mv | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| publishDate | 2024 |
| publisher | Wiley |
| record_format | wiley_oa |
| spellingShingle | Comparison of intranasal atipamezole by atomization or drops with intramuscular injection for reversing sedative effects of medetomidine in healthy dogs Majid Jafarbeglou Mehdi Marjani Mohammadreza Oghbaei Mohammadreza Paryani Reza Bakhshi‐Khanghah Journal of Veterinary Emergency and Critical Care Comparison of intranasal atipamezole by atomization or drops with intramuscular injection for reversing sedative effects of medetomidine in healthy dogs Majid Jafarbeglou Mehdi Marjani Mohammadreza Oghbaei Mohammadreza Paryani Reza Bakhshi‐Khanghah Journal of Veterinary Emergency and Critical Care AbstractObjectiveTo determine and compare the efficacy of intranasal (IN) atomization, IN drops, and IM injection of atipamezole for reversal of medetomidine‐induced sedation in healthy dogs.DesignProspective, randomized, blinded study.SettingUniversity teaching hospital.AnimalsForty mixed‐breed, shelter‐owned dogs with an average weight of 29.9 ± 5.6 kg (mean ± SD) that required sedation for minor diagnostic or therapeutic procedures.InterventionsAtipamezole was administered by a dog handler at 200 µg/kg via IN atomization (ATI‐INA, n = 10), IN drops (ATI‐IND, n = 10), or IM injection (ATI‐IM, n = 10) 20 minutes following medetomidine administration (40 µg/kg). A control group (n = 10) received no atipamezole.Measurements and Main ResultsEase of atipamezole administration was evaluated. Sedation score, heart rate (HR), respiratory rate (RR), and blood pressure (BP) were recorded pre‐medetomidine administration (T0), pre‐atipamezole administration (T20), and at multiple intervals following atipamezole administration. ATI‐IM resulted in the fastest recovery, followed by ATI‐INA, with ATI‐IND being the slowest. The adverse cardiovascular impacts of medetomidine were not completely mitigated. ATI‐IM showed initial HR restoration followed by a decline. HR in both IN groups showed a slower increase compared to ATI‐IM, but no subsequent decline was observed. ATI‐IM resulted in a transient decrease in BP, though dogs remained normotensive. A gradual reduction in BP was noted in the IN groups. At T50, RR of all atipamezole groups differed from control, and a significant increase in RR was observed in ATI‐IM dogs compared to pre‐atipamezole value. No adverse effects were observed.ConclusionsAll routes for atipamezole administration effectively reversed medetomidine‐induced sedation, with ATI‐IM being fastest. IN routes were easy for the dog handler to administer, making them viable alternatives in cases of accidental drug exposure, particularly outside a hospital setting. 10.1111/vec.13439 http://onlinelibrary.wiley.com/termsAndConditions#vor |
| title | Comparison of intranasal atipamezole by atomization or drops with intramuscular injection for reversing sedative effects of medetomidine in healthy dogs |
| topic | Journal of Veterinary Emergency and Critical Care |
| url | https://onlinelibrary.wiley.com/doi/10.1111/vec.13439 |