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| Main Authors: | , , , , |
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| Format: | Artículo Open Access |
| Published: |
Wiley
2026
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| Subjects: | |
| Online Access: | https://onlinelibrary.wiley.com/doi/10.1111/vec.70091 |
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Table of Contents:
- Mastoparan as a Potential Cause of Hemolytic Anemia Due to a Suspected Single Wasp Sting in a Dog Shunya Yokota Hiroto Taira Hiroki Ikezawa Satoshi Ishii Masashi Yuki Journal of Veterinary Emergency and Critical Care ABSTRACT Objective In people, severe Hymenoptera stings can lead to systemic allergic reactions, acute kidney injury, rhabdomyolysis, hemolysis, shock, and even death. Hemolytic anemia as a result of multiple honeybee stings has been reported in dogs; however, there are no prior reports of hemolytic anemia due to wasp stings in the dog. In this report, we present a case of a dog that developed hemolytic anemia after a single wasp sting. We also report the vulnerability of RBCs to the wasp venom using an in vitro hemolysis assay. Case Summary A 3‐year‐old neutered male Yorkshire Terrier presented with hemoglobinuria 4 h after a suspected single wasp sting and achieved complete remission after a short course of treatment with glucocorticoids and IV infusion, without long‐term sequelae. An in vitro hemolysis assay using mastoparan, a major wasp venom constituent, was performed to test our hypothesis that increased sensitivity of the RBC membrane to wasp venom would lead to hemolysis after exposure to a small amount of venom by a single sting. Although no difference in the amount of mastoparan leading to hemolysis in 50% of the RBCs (HC 50 ) was seen between the patient and two healthy controls, the HC 50 was higher in whole blood samples. New and Unique Information This is the first report demonstrating that even a single wasp sting can cause hemolysis in dogs. In addition, based on our in vitro hemolysis assay, plasma may have an inhibitory effect on mastoparan‐induced hemolysis. 10.1111/vec.70091 http://onlinelibrary.wiley.com/termsAndConditions#vor