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| Format: | Artículo Open Access |
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Wiley
2026
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| Online-Zugang: | https://onlinelibrary.wiley.com/doi/10.1111/vec.70096 |
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Inhaltsangabe:
- Retrospective Assessment of the Oxygenation Index in Dogs Undergoing Mechanical Ventilation for Primary Pulmonary Parenchymal Disease Tereza Stastny Jiwoong Her Curtis G. Rheingold Nick Jordan Dana J. Caldwell Rebecka S. Hess Deborah C. Silverstein Jeongmin Lee Journal of Veterinary Emergency and Critical Care ABSTRACT Objective To assess the association between the oxygenation index (OI) and survival in mechanically ventilated dogs with primary pulmonary parenchymal disease. Design Retrospective, multicenter study. Setting Three veterinary medical teaching institutions and one private veterinary referral center. Animals Seventy‐nine client‐owned dogs. Interventions None. Methods OI, calculated as (mean airway pressure × FiO 2 × 100) / PaO 2 , and the PaO 2 /FiO 2 (PF) ratio were calculated for dogs undergoing mechanical ventilation for primary pulmonary disease. Median OI was lower in survivors (2.6) than nonsurvivors (6.6; p < 0.001), while PF was higher in survivors (317.9 vs. 177.9; p < 0.001). OI predicted mortality with an area under the receiver operating characteristic curve of 0.73, sensitivity of 65%, and specificity of 80% at an optimal cutoff of 4.3. Median PF had an area under the receiver operating characteristic curve of 0.72, sensitivity of 70%, and specificity of 73% at an optimal cutoff of 237.8. Each 1‐unit increase in OI was associated with a 35% higher mortality risk (odds ratio: 1.35; 95% confidence interval: 1.14–1.61). Survivors showed greater improvement in OI during ventilation ( p = 0.004). Using Pediatric Acute Lung Injury Consensus Conference and pediatric acute respiratory distress syndrome thresholds, survival likelihood declined with increasing severity, with no survivors in the severe category (OI >16). Similar trends were observed using updated Pediatric Acute Lung Injury Consensus Conference‐2 criteria and acute respiratory distress syndrome severity classifications. Conclusions Higher OI values and lower PF ratios were associated with mortality in this group of mechanically ventilated dogs, with both metrics demonstrating similar predictive accuracy. Results suggest species‐specific OI and PF thresholds are needed. 10.1111/vec.70096 http://creativecommons.org/licenses/by/4.0/